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Article: Genetics of Lumbar Disk Degeneration: Technology, Study Designs, and Risk Factors

TitleGenetics of Lumbar Disk Degeneration: Technology, Study Designs, and Risk Factors
Authors
KeywordsAssociation study
Familial aggregation
Genetics
Lumbar disk degeneration
Twin studies
Issue Date2011
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/cort
Citation
Orthopedic Clinics Of North America, 2011, v. 42 n. 4, p. 479-486 How to Cite?
AbstractLumbar disk degeneration (LDD) is a common musculoskeletal condition. Genetic risk factors have been suggested to play a major role in its cause. This article reviews the main research strategies that have been used to study the genetics of LDD, and the genes that thus far have been identified to influence susceptibility to LDD. With the rapid progress in genomic technologies, further advances in the genetics of LDD are expected in the next few years. © 2011 Elsevier Inc.
Persistent Identifierhttp://hdl.handle.net/10722/147641
ISSN
2015 Impact Factor: 1.51
2015 SCImago Journal Rankings: 0.784
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKao, PYPen_HK
dc.contributor.authorChan, Den_HK
dc.contributor.authorSamartzis, Den_HK
dc.contributor.authorSham, PCen_HK
dc.contributor.authorSong, YQen_HK
dc.date.accessioned2012-05-29T06:05:10Z-
dc.date.available2012-05-29T06:05:10Z-
dc.date.issued2011en_HK
dc.identifier.citationOrthopedic Clinics Of North America, 2011, v. 42 n. 4, p. 479-486en_HK
dc.identifier.issn0030-5898en_HK
dc.identifier.urihttp://hdl.handle.net/10722/147641-
dc.description.abstractLumbar disk degeneration (LDD) is a common musculoskeletal condition. Genetic risk factors have been suggested to play a major role in its cause. This article reviews the main research strategies that have been used to study the genetics of LDD, and the genes that thus far have been identified to influence susceptibility to LDD. With the rapid progress in genomic technologies, further advances in the genetics of LDD are expected in the next few years. © 2011 Elsevier Inc.en_HK
dc.languageengen_US
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/corten_HK
dc.relation.ispartofOrthopedic Clinics of North Americaen_HK
dc.rightsNOTICE: this is the author’s version of a work that was accepted for publication in Orthopedic Clinics of North America. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Orthopedic Clinics of North America, 2011, v. 42 n. 4, p. 479-486. DOI: 10.1016/j.ocl.2011.07.011-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectAssociation studyen_HK
dc.subjectFamilial aggregationen_HK
dc.subjectGeneticsen_HK
dc.subjectLumbar disk degenerationen_HK
dc.subjectTwin studiesen_HK
dc.subject.meshAge Factorsen_US
dc.subject.meshCross-Sectional Studiesen_US
dc.subject.meshDisease Progressionen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenetic Predisposition To Disease - Epidemiologyen_US
dc.subject.meshGenetic Testingen_US
dc.subject.meshGenomicsen_US
dc.subject.meshHumansen_US
dc.subject.meshIntervertebral Disc Degeneration - Genetics - Physiopathologyen_US
dc.subject.meshLow Back Pain - Genetics - Physiopathologyen_US
dc.subject.meshLumbar Vertebraeen_US
dc.subject.meshMaleen_US
dc.subject.meshPrognosisen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshSeverity Of Illness Indexen_US
dc.titleGenetics of Lumbar Disk Degeneration: Technology, Study Designs, and Risk Factorsen_HK
dc.typeArticleen_HK
dc.identifier.emailChan, D: chand@hku.hken_HK
dc.identifier.emailSamartzis, D: dspine@hku.hken_HK
dc.identifier.emailSham, PC: pcsham@hku.hken_HK
dc.identifier.emailSong, YQ: songy@hku.hken_HK
dc.identifier.authorityChan, D=rp00540en_HK
dc.identifier.authoritySamartzis, D=rp01430en_HK
dc.identifier.authoritySham, PC=rp00459en_HK
dc.identifier.authoritySong, YQ=rp00488en_HK
dc.description.naturepostprinten_US
dc.identifier.doi10.1016/j.ocl.2011.07.011en_HK
dc.identifier.pmid21944585-
dc.identifier.scopuseid_2-s2.0-80053184385en_HK
dc.identifier.hkuros205924-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80053184385&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume42en_HK
dc.identifier.issue4en_HK
dc.identifier.spage479en_HK
dc.identifier.epage486en_HK
dc.identifier.isiWOS:000208681100004-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridYuPing Kao, P=51664291000en_HK
dc.identifier.scopusauthoridChan, D=7402216545en_HK
dc.identifier.scopusauthoridSamartzis, D=34572771100en_HK
dc.identifier.scopusauthoridSham, PC=34573429300en_HK
dc.identifier.scopusauthoridSong, YQ=7404921212en_HK

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