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Article: Influence of low-dose nicotine on bone healing

TitleInfluence of low-dose nicotine on bone healing
Authors
KeywordsBone healing
Bone morphogenetic protein-2
Bone radiodensity
Distraction osteogenesis
Nicotine
Issue Date2011
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.jtrauma.com
Citation
Journal Of Trauma - Injury, Infection And Critical Care, 2011, v. 70 n. 6, p. E117-E121 How to Cite?
AbstractBACKGROUND: Nicotine at a low concentration was suggested as a new topical drug for clinical application. It has been reported to be capable of enhancing skin wound healing. This study was designed to assess the effect of nicotine administration at a low dose on bone regeneration using a rabbit model of mandibular distraction osteogenesis. METHODS: Twenty New Zealand white rabbits were randomly assigned to nicotine group and control group. A total of 0.75 g, 60-day time release, nicotine pellets or placebos were implanted in the neck subcutaneous tissue of the rabbits. The nicotine or placebo exposure time for all the animals was 7 weeks. Unilateral mandibular distraction osteogenesis was performed. Five animals in each group were killed on week 2 and week 4 of consolidation, respectively. The mandibular samples were subjected to radiographic, histologic, and immunohistochemical analysis. RESULTS: Nicotine at low dose showed no significant effect on the expression of bone morphogenetic protein-2 and on the radiodensity of bone regeneration. However, the delayed bone healing was detected in the nicotine group by histologic examination. CONCLUSIONS: These findings imply a potential risk of compromised bone healing in patients taking nicotine medication. Further clinical studies are necessary to assess the risk of nicotine medication on reconstructive surgery. © 2011 Lippincott Williams & Wilkins, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/147633
ISSN
2013 Impact Factor: 2.961
ISI Accession Number ID
Funding AgencyGrant Number
University of Hong KongHKU200907176219
Industrial Centre of the Hong Kong Polytechnic University
Funding Information:

Supported by the Small Project Funding Programme (Reference code: HKU200907176219) of the University of Hong Kong.

References

 

DC FieldValueLanguage
dc.contributor.authorMa, Len_HK
dc.contributor.authorSham, MHen_HK
dc.contributor.authorZheng, LWen_HK
dc.contributor.authorCheung, LKen_HK
dc.date.accessioned2012-05-29T06:05:07Z-
dc.date.available2012-05-29T06:05:07Z-
dc.date.issued2011en_HK
dc.identifier.citationJournal Of Trauma - Injury, Infection And Critical Care, 2011, v. 70 n. 6, p. E117-E121en_HK
dc.identifier.issn0022-5282en_HK
dc.identifier.urihttp://hdl.handle.net/10722/147633-
dc.description.abstractBACKGROUND: Nicotine at a low concentration was suggested as a new topical drug for clinical application. It has been reported to be capable of enhancing skin wound healing. This study was designed to assess the effect of nicotine administration at a low dose on bone regeneration using a rabbit model of mandibular distraction osteogenesis. METHODS: Twenty New Zealand white rabbits were randomly assigned to nicotine group and control group. A total of 0.75 g, 60-day time release, nicotine pellets or placebos were implanted in the neck subcutaneous tissue of the rabbits. The nicotine or placebo exposure time for all the animals was 7 weeks. Unilateral mandibular distraction osteogenesis was performed. Five animals in each group were killed on week 2 and week 4 of consolidation, respectively. The mandibular samples were subjected to radiographic, histologic, and immunohistochemical analysis. RESULTS: Nicotine at low dose showed no significant effect on the expression of bone morphogenetic protein-2 and on the radiodensity of bone regeneration. However, the delayed bone healing was detected in the nicotine group by histologic examination. CONCLUSIONS: These findings imply a potential risk of compromised bone healing in patients taking nicotine medication. Further clinical studies are necessary to assess the risk of nicotine medication on reconstructive surgery. © 2011 Lippincott Williams & Wilkins, Inc.en_HK
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.jtrauma.comen_HK
dc.relation.ispartofJournal of Trauma - Injury, Infection and Critical Careen_HK
dc.subjectBone healingen_HK
dc.subjectBone morphogenetic protein-2en_HK
dc.subjectBone radiodensityen_HK
dc.subjectDistraction osteogenesisen_HK
dc.subjectNicotineen_HK
dc.subject.meshAnimalsen_US
dc.subject.meshBone Regeneration - Drug Effectsen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshMandible - Drug Effects - Radiography - Surgeryen_US
dc.subject.meshNicotine - Pharmacologyen_US
dc.subject.meshOsteogenesis, Distractionen_US
dc.subject.meshPlacebosen_US
dc.subject.meshRabbitsen_US
dc.subject.meshRandom Allocationen_US
dc.subject.meshX-Ray Microtomographyen_US
dc.titleInfluence of low-dose nicotine on bone healingen_HK
dc.typeArticleen_HK
dc.identifier.emailSham, MH:mhsham@hkucc.hku.hken_HK
dc.identifier.emailZheng, LW:lwzheng@hku.hken_HK
dc.identifier.emailCheung, LK:lkcheung@hkucc.hku.hken_HK
dc.identifier.authoritySham, MH=rp00380en_HK
dc.identifier.authorityZheng, LW=rp01411en_HK
dc.identifier.authorityCheung, LK=rp00013en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1097/TA.0b013e3181e80daben_HK
dc.identifier.pmid20805768-
dc.identifier.scopuseid_2-s2.0-79958783108en_HK
dc.identifier.hkuros210149-
dc.identifier.hkuros170974-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79958783108&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume70en_HK
dc.identifier.issue6en_HK
dc.identifier.spageE117en_HK
dc.identifier.epageE121en_HK
dc.identifier.isiWOS:000291478500004-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridMa, L=36072648200en_HK
dc.identifier.scopusauthoridSham, MH=7003729109en_HK
dc.identifier.scopusauthoridZheng, LW=11241247300en_HK
dc.identifier.scopusauthoridCheung, LK=7102302747en_HK

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