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Article: Novel aspects of corneal angiogenic and lymphangiogenic privilege

TitleNovel aspects of corneal angiogenic and lymphangiogenic privilege
Authors
Issue Date2010
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/preteyeres
Citation
Progress In Retinal And Eye Research, 2010, v. 29 n. 3, p. 208-248 How to Cite?
AbstractIn this article, we provide the results of experimental studies demonstrating that corneal avascularity is an active process involving the production of anti-angiogenic factors, which counterbalance the pro-angiogenic/lymphangiogenic factors that are upregulated during wound healing. We also summarize pertinent published reports regarding corneal neovascularization (NV), corneal lymphangiogenesis and corneal angiogenic/lymphangiogenic privilege. We outline the clinical causes of corneal NV, and discuss the angiogenic proteins (VEGF and bFGF) and angiogenesis regulatory proteins. We also describe the role of matrix metalloproteinases MMP-2, -7, and MT1-MMP, anti-angiogenic factors, and lymphangiogenic regulatory proteins during corneal wound healing. Established and potential new therapies for the treatment of corneal neovascularization are also discussed. © 2010.
Persistent Identifierhttp://hdl.handle.net/10722/147618
ISSN
2015 Impact Factor: 9.394
2015 SCImago Journal Rankings: 5.073
ISI Accession Number ID
Funding AgencyGrant Number
Research to Prevent Blindness, New York, NY
EY01792
EY14048
EY10101
Funding Information:

Supported by: EY01792 (DTA), EY14048 (JHC), EY10101 (DTA), and an unrestricted grant from Research to Prevent Blindness, New York, NY.

References

 

DC FieldValueLanguage
dc.contributor.authorEllenberg, Den_US
dc.contributor.authorAzar, DTen_US
dc.contributor.authorHallak, JAen_US
dc.contributor.authorTobaigy, Fen_US
dc.contributor.authorHan, KYen_US
dc.contributor.authorJain, Sen_US
dc.contributor.authorZhou, Zen_US
dc.contributor.authorChang, JHen_US
dc.date.accessioned2012-05-29T06:05:00Z-
dc.date.available2012-05-29T06:05:00Z-
dc.date.issued2010en_US
dc.identifier.citationProgress In Retinal And Eye Research, 2010, v. 29 n. 3, p. 208-248en_US
dc.identifier.issn1350-9462en_US
dc.identifier.urihttp://hdl.handle.net/10722/147618-
dc.description.abstractIn this article, we provide the results of experimental studies demonstrating that corneal avascularity is an active process involving the production of anti-angiogenic factors, which counterbalance the pro-angiogenic/lymphangiogenic factors that are upregulated during wound healing. We also summarize pertinent published reports regarding corneal neovascularization (NV), corneal lymphangiogenesis and corneal angiogenic/lymphangiogenic privilege. We outline the clinical causes of corneal NV, and discuss the angiogenic proteins (VEGF and bFGF) and angiogenesis regulatory proteins. We also describe the role of matrix metalloproteinases MMP-2, -7, and MT1-MMP, anti-angiogenic factors, and lymphangiogenic regulatory proteins during corneal wound healing. Established and potential new therapies for the treatment of corneal neovascularization are also discussed. © 2010.en_US
dc.languageengen_US
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/preteyeresen_US
dc.relation.ispartofProgress in Retinal and Eye Researchen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCornea - Metabolism - Pathologyen_US
dc.subject.meshCorneal Neovascularization - Etiology - Metabolism - Pathologyen_US
dc.subject.meshDisease Models, Animalen_US
dc.subject.meshFibroblast Growth Factors - Metabolismen_US
dc.subject.meshGene Expression Regulation - Physiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshLymphangiogenesis - Genetics - Physiologyen_US
dc.subject.meshMatrix Metalloproteinases - Genetics - Metabolismen_US
dc.subject.meshVascular Endothelial Growth Factor A - Metabolismen_US
dc.subject.meshWound Healing - Physiologyen_US
dc.titleNovel aspects of corneal angiogenic and lymphangiogenic privilegeen_US
dc.typeArticleen_US
dc.identifier.emailZhou, Z:zhongjun@hkucc.hku.hken_US
dc.identifier.authorityZhou, Z=rp00503en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.preteyeres.2010.01.002en_US
dc.identifier.pmid20100589-
dc.identifier.scopuseid_2-s2.0-77951206611en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77951206611&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume29en_US
dc.identifier.issue3en_US
dc.identifier.spage208en_US
dc.identifier.epage248en_US
dc.identifier.isiWOS:000277826800003-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridEllenberg, D=14059790000en_US
dc.identifier.scopusauthoridAzar, DT=26643368400en_US
dc.identifier.scopusauthoridHallak, JA=15122112400en_US
dc.identifier.scopusauthoridTobaigy, F=15123368000en_US
dc.identifier.scopusauthoridHan, KY=7402960197en_US
dc.identifier.scopusauthoridJain, S=35184745300en_US
dc.identifier.scopusauthoridZhou, Z=8631856300en_US
dc.identifier.scopusauthoridChang, JH=22333289500en_US
dc.identifier.citeulike6599254-

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