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Article: Helicases as antiviral drug targets.

TitleHelicases as antiviral drug targets.
Authors
Issue Date2008
PublisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org/resources/supp.html
Citation
Hong Kong Medical Journal = Xianggang Yi Xue Za Zhi, 2008, v. 14 Suppl 4, p. 36-38 How to Cite?
Abstract1. We have demonstrated for the first time that the helicase of a ribonucleic acid virus, the SARS coronavirus (SARS-CoV), is a valid target for drug development. 2. Using high throughput screen and chemical synthesis, several lead compounds targeting the SARS-CoV helicase have been identified. We have shown that these compounds can inhibit SARS-CoV helicase activity and viral growth in cell culture systems. These compounds can potentially be used to target other viruses.
Persistent Identifierhttp://hdl.handle.net/10722/147612
ISSN
2015 Impact Factor: 0.887
2015 SCImago Journal Rankings: 0.279

 

DC FieldValueLanguage
dc.contributor.authorHuang, JDen_HK
dc.contributor.authorZheng, BJen_HK
dc.contributor.authorSun, HZen_HK
dc.date.accessioned2012-05-29T06:04:58Z-
dc.date.available2012-05-29T06:04:58Z-
dc.date.issued2008en_HK
dc.identifier.citationHong Kong Medical Journal = Xianggang Yi Xue Za Zhi, 2008, v. 14 Suppl 4, p. 36-38en_HK
dc.identifier.issn1024-2708en_HK
dc.identifier.urihttp://hdl.handle.net/10722/147612-
dc.description.abstract1. We have demonstrated for the first time that the helicase of a ribonucleic acid virus, the SARS coronavirus (SARS-CoV), is a valid target for drug development. 2. Using high throughput screen and chemical synthesis, several lead compounds targeting the SARS-CoV helicase have been identified. We have shown that these compounds can inhibit SARS-CoV helicase activity and viral growth in cell culture systems. These compounds can potentially be used to target other viruses.en_HK
dc.languageengen_US
dc.publisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org/resources/supp.htmlen_HK
dc.relation.ispartofHong Kong medical journal = Xianggang yi xue za zhien_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshAnimalsen_US
dc.subject.meshAntiviral Agents - Pharmacologyen_US
dc.subject.meshCells, Cultureden_US
dc.subject.meshCercopithecus Aethiopsen_US
dc.subject.meshDna Helicases - Genetics - Pharmacologyen_US
dc.subject.meshDrug Delivery Systemsen_US
dc.subject.meshDrug Evaluation, Preclinicalen_US
dc.subject.meshSars Virus - Drug Effects - Geneticsen_US
dc.subject.meshSensitivity And Specificityen_US
dc.subject.meshSevere Acute Respiratory Syndrome - Drug Therapy - Genetics - Virologyen_US
dc.subject.meshVero Cells - Cytology - Drug Effectsen_US
dc.subject.meshVirus Replication - Drug Effects - Geneticsen_US
dc.titleHelicases as antiviral drug targets.en_HK
dc.typeArticleen_HK
dc.identifier.emailHuang, JD:jdhuang@hkucc.hku.hken_HK
dc.identifier.emailZheng, BJ:bzheng@hkucc.hku.hken_HK
dc.identifier.emailSun, HZ:hsun@hkucc.hku.hken_HK
dc.identifier.authorityHuang, JD=rp00451en_HK
dc.identifier.authorityZheng, BJ=rp00353en_HK
dc.identifier.authoritySun, HZ=rp00777en_HK
dc.description.naturepublished_or_final_versionen_US
dc.identifier.pmid18708673-
dc.identifier.scopuseid_2-s2.0-70449808450en_HK
dc.identifier.hkuros156456-
dc.identifier.volume14 Suppl 4en_HK
dc.identifier.spage36en_HK
dc.identifier.epage38en_HK
dc.publisher.placeHong Kongen_HK
dc.identifier.scopusauthoridHuang, JD=8108660600en_HK
dc.identifier.scopusauthoridZheng, BJ=7201780588en_HK
dc.identifier.scopusauthoridSun, HZ=7404827446en_HK

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