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Article: Experimental therapy for solid tumors by in situ retro viral mediated gene transfer

TitleExperimental therapy for solid tumors by in situ retro viral mediated gene transfer
Authors
KeywordsGene Therapy
Hsv-Tk
Tumor
Issue Date1995
PublisherChina Anti-Cancer Association. The Journal's web site is located at http://zgazyj.periodicals.net.cn/
Citation
Chinese Journal Of Cancer Research, 1995, v. 7 n. 3, p. 177-180 How to Cite?
AbstractAlthough chemotherapy play main role in treatment for cancer, gene therapy is thought to be practical approach of treatment in future. Thymidine kinase gene were delivered into proliferating cells by the retroviral mediated gene transfer system in the culture cells. Cytotoxic effect of the TK recipient GCV treated cells correlated with the growth rate of cells. The rapid proliferating tumor cell HR8348 were inhibited more efficiently than slow proliferating cells. In vivo, simultaneously introduced TK producer cells released virus particles continuously into neighboring tumor cells, GCV treatment can inhibit the growth of tumor compared with control. The inhibition also correlated the number of injected TK producer cells. 0.1 ml 100 mg/ml 795 tumor suspension and 2×106TK producer cells inoculated mice achieved 37% inhibition while 1×107 TK producer cells injection achieved 66% inhibition. The completely regression could not be achieved under this circumstance. Our results suggest TK gene transfer followed GCV treatment merit further evaluation as novel antineoplastic approach. © 1995 Chinese Journal of Cancer Research.
Persistent Identifierhttp://hdl.handle.net/10722/147600
ISSN
2015 Impact Factor: 2.201
2015 SCImago Journal Rankings: 0.727

 

DC FieldValueLanguage
dc.contributor.authorZhou, Zen_US
dc.contributor.authorZhou, Aen_US
dc.contributor.authorWang, Jen_US
dc.contributor.authorTang, Jen_US
dc.contributor.authorNiu, Den_US
dc.contributor.authorLin, Cen_US
dc.date.accessioned2012-05-29T06:04:52Z-
dc.date.available2012-05-29T06:04:52Z-
dc.date.issued1995en_US
dc.identifier.citationChinese Journal Of Cancer Research, 1995, v. 7 n. 3, p. 177-180en_US
dc.identifier.issn1000-9604en_US
dc.identifier.urihttp://hdl.handle.net/10722/147600-
dc.description.abstractAlthough chemotherapy play main role in treatment for cancer, gene therapy is thought to be practical approach of treatment in future. Thymidine kinase gene were delivered into proliferating cells by the retroviral mediated gene transfer system in the culture cells. Cytotoxic effect of the TK recipient GCV treated cells correlated with the growth rate of cells. The rapid proliferating tumor cell HR8348 were inhibited more efficiently than slow proliferating cells. In vivo, simultaneously introduced TK producer cells released virus particles continuously into neighboring tumor cells, GCV treatment can inhibit the growth of tumor compared with control. The inhibition also correlated the number of injected TK producer cells. 0.1 ml 100 mg/ml 795 tumor suspension and 2×106TK producer cells inoculated mice achieved 37% inhibition while 1×107 TK producer cells injection achieved 66% inhibition. The completely regression could not be achieved under this circumstance. Our results suggest TK gene transfer followed GCV treatment merit further evaluation as novel antineoplastic approach. © 1995 Chinese Journal of Cancer Research.en_US
dc.languageengen_US
dc.publisherChina Anti-Cancer Association. The Journal's web site is located at http://zgazyj.periodicals.net.cn/en_US
dc.relation.ispartofChinese Journal of Cancer Researchen_US
dc.subjectGene Therapyen_US
dc.subjectHsv-Tken_US
dc.subjectTumoren_US
dc.titleExperimental therapy for solid tumors by in situ retro viral mediated gene transferen_US
dc.typeArticleen_US
dc.identifier.emailZhou, Z:zhongjun@hkucc.hku.hken_US
dc.identifier.authorityZhou, Z=rp00503en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/BF03023470en_US
dc.identifier.scopuseid_2-s2.0-65749310451en_US
dc.identifier.volume7en_US
dc.identifier.issue3en_US
dc.identifier.spage177en_US
dc.identifier.epage180en_US
dc.publisher.placeChinaen_US
dc.identifier.scopusauthoridZhou, Z=8631856300en_US
dc.identifier.scopusauthoridZhou, A=7202762670en_US
dc.identifier.scopusauthoridWang, J=8631854400en_US
dc.identifier.scopusauthoridTang, J=13805190800en_US
dc.identifier.scopusauthoridNiu, D=7006150864en_US
dc.identifier.scopusauthoridLin, C=35460305100en_US

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