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Article: Neuronal plasticity of otolith-related vestibular system

TitleNeuronal plasticity of otolith-related vestibular system
与耳石器官有关的前庭系统可塑性的变化
Authors
KeywordsGlutamate receptor
Otolithic organ
Spatial recognition
Vestibular system compensation
Issue Date2008
Publisher中國醫學科學院. The Journal's website is located at http://med.wanfangdata.com.cn/Journal/zgyxkxyxb.aspx
Citation
Acta Academiae Medicinae Sinicae, 2008, v. 30 n. 6, p. 741-746 How to Cite?
中国医学科学院学报, 2008, v. 30 n. 6, p. 741-746 How to Cite?
AbstractThis review focuses on our effort in addressing the development and lesion-induced plasticity of the gravity sensing system. After severance of sensory input from one inner ear, there is a bilateral imbalance in response dynamics and spatial coding behavior between neuronal subpopulations on the two sides. These data provide the basis for deranged spatial coding and motor deficits accompanying unilateral labyrinthectomy. Recent studies have also confirmed that both glutamate receptors and neurotrophin receptors within the bilateral vestibular nuclei are implicated in the plasticity during vestibular compensation and development. Changes in plasticity not only provide insight into the formation of a spatial map and recovery of vestibular function but also on the design of drugs for therapeutic strategies applicable to infants or vestibular disorders such as vertigo and dizziness.
本文主要探讨与耳石器官有关的中枢神经系统在成年动物前庭器官受损后町塑性的变化。当单侧前庭器官受损后,左右两侧前庭核内神经细胞对平衡刺激的反应和空间定向能力明显出现不对称性。这项发现将为空间定向能力的失调、平衡障碍和运动病等提供细胞病理基础。另外,前庭代偿能力与双侧前庭核内神经营养因子和谷氨酸受体的改变有密切关系,该类受体在前庭神经细胞发育过程中均有不同的表达。这些实验数据不但对研究成年动物脑平衡感觉图谱的空间调控和前庭系统的修补和代偿提供重要资料,并为太空科学和临床医学,特别是研制药物治疗因耳石问题引发的眩晕疾病等各方面提供理论基础。
Persistent Identifierhttp://hdl.handle.net/10722/147595
ISSN
2015 SCImago Journal Rankings: 0.151
References

 

DC FieldValueLanguage
dc.contributor.authorLai, SKen_HK
dc.contributor.authorLai, CHen_HK
dc.contributor.authorZhang, FXen_HK
dc.contributor.authorMa, CWen_HK
dc.contributor.authorShum, DKYen_HK
dc.contributor.authorChan, YSen_HK
dc.date.accessioned2012-05-29T06:04:50Z-
dc.date.available2012-05-29T06:04:50Z-
dc.date.issued2008en_HK
dc.identifier.citationActa Academiae Medicinae Sinicae, 2008, v. 30 n. 6, p. 741-746en_HK
dc.identifier.citation中国医学科学院学报, 2008, v. 30 n. 6, p. 741-746-
dc.identifier.issn1000-503Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/147595-
dc.description.abstractThis review focuses on our effort in addressing the development and lesion-induced plasticity of the gravity sensing system. After severance of sensory input from one inner ear, there is a bilateral imbalance in response dynamics and spatial coding behavior between neuronal subpopulations on the two sides. These data provide the basis for deranged spatial coding and motor deficits accompanying unilateral labyrinthectomy. Recent studies have also confirmed that both glutamate receptors and neurotrophin receptors within the bilateral vestibular nuclei are implicated in the plasticity during vestibular compensation and development. Changes in plasticity not only provide insight into the formation of a spatial map and recovery of vestibular function but also on the design of drugs for therapeutic strategies applicable to infants or vestibular disorders such as vertigo and dizziness.en_HK
dc.description.abstract本文主要探讨与耳石器官有关的中枢神经系统在成年动物前庭器官受损后町塑性的变化。当单侧前庭器官受损后,左右两侧前庭核内神经细胞对平衡刺激的反应和空间定向能力明显出现不对称性。这项发现将为空间定向能力的失调、平衡障碍和运动病等提供细胞病理基础。另外,前庭代偿能力与双侧前庭核内神经营养因子和谷氨酸受体的改变有密切关系,该类受体在前庭神经细胞发育过程中均有不同的表达。这些实验数据不但对研究成年动物脑平衡感觉图谱的空间调控和前庭系统的修补和代偿提供重要资料,并为太空科学和临床医学,特别是研制药物治疗因耳石问题引发的眩晕疾病等各方面提供理论基础。-
dc.languagechien_US
dc.publisher中國醫學科學院. The Journal's website is located at http://med.wanfangdata.com.cn/Journal/zgyxkxyxb.aspx-
dc.relation.ispartofActa Academiae Medicinae Sinicaeen_HK
dc.relation.ispartof中国医学科学院学报-
dc.subjectGlutamate receptoren_HK
dc.subjectOtolithic organen_HK
dc.subjectSpatial recognitionen_HK
dc.subjectVestibular system compensationen_HK
dc.subject.meshAnimalsen_US
dc.subject.meshHumansen_US
dc.subject.meshNeuronal Plasticityen_US
dc.subject.meshNeurons - Physiologyen_US
dc.subject.meshOtolithic Membrane - Innervation - Physiologyen_US
dc.subject.meshVestibule, Labyrinth - Innervation - Physiologyen_US
dc.titleNeuronal plasticity of otolith-related vestibular systemen_HK
dc.title与耳石器官有关的前庭系统可塑性的变化-
dc.typeArticleen_HK
dc.identifier.emailLai, CH: chlaib@hku.hken_HK
dc.identifier.emailShum, DKY: shumdkhk@hkucc.hku.hken_HK
dc.identifier.emailChan, YS: yschan@hkucc.hku.hken_HK
dc.identifier.authorityLai, CH=rp00396en_HK
dc.identifier.authorityShum, DKY=rp00321en_HK
dc.identifier.authorityChan, YS=rp00318en_HK
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.3881/j.issn.1000-503X.2008.06.023en_HK
dc.identifier.pmid19180927-
dc.identifier.scopuseid_2-s2.0-58349101986en_HK
dc.identifier.hkuros164128-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-58349101986&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume30en_HK
dc.identifier.issue6en_HK
dc.identifier.spage741en_HK
dc.identifier.epage746en_HK
dc.identifier.scopusauthoridLai, SK=7402937165en_HK
dc.identifier.scopusauthoridLai, CH=7403086597en_HK
dc.identifier.scopusauthoridZhang, FX=7404969043en_HK
dc.identifier.scopusauthoridMa, CW=15765898900en_HK
dc.identifier.scopusauthoridShum, DKY=7004824447en_HK
dc.identifier.scopusauthoridChan, YS=7403676627en_HK

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