File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)

Article: (ii) Family-based linkage and case control association studies

Title(ii) Family-based linkage and case control association studies
Authors
Keywordscandidate gene approach
Linkage analysis
Issue Date2008
PublisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/cuor
Citation
Current Orthopaedics, 2008, v. 22 n. 4, p. 245-250 How to Cite?
AbstractDisease gene mapping is the first step towards our ultimate goal for understanding the etiology of a disease. Family-based linkage analysis and population-based association studies have been combining successfully as the workhorses for hunting disease genes in the past decades and are performed concurrently. To attain an adequate balance between maximizing the chance of discovering potential disease-causing genes and minimizing the cost of study implementation, an optimal study design is necessary. Important issues on the basics of human genetics, principles of linkage analysis and association studies, advantages and limitations of individual strategies, as well as practical procedures in conducting disease gene mapping are discussed in detail. © 2008 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/147590
ISSN
2008 Impact Factor: 0.288
ISI Accession Number ID
Funding AgencyGrant Number
University Grants Committee of Hong for KongAoE/M-04/04
Research Grants Council of Hong KongHKU7509/03M
Funding Information:

This work was supported by grants from the University Grants Committee of Hong for Kong (AoE/M-04/04) and the Research Grants Council of Hong Kong (HKU7509/03M).

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorHo, DWHen_HK
dc.contributor.authorChan, Den_HK
dc.contributor.authorCheung, KMCen_HK
dc.contributor.authorSham, Pen_HK
dc.contributor.authorSong, YQen_HK
dc.date.accessioned2012-05-29T06:04:49Z-
dc.date.available2012-05-29T06:04:49Z-
dc.date.issued2008en_HK
dc.identifier.citationCurrent Orthopaedics, 2008, v. 22 n. 4, p. 245-250en_HK
dc.identifier.issn0268-0890en_HK
dc.identifier.urihttp://hdl.handle.net/10722/147590-
dc.description.abstractDisease gene mapping is the first step towards our ultimate goal for understanding the etiology of a disease. Family-based linkage analysis and population-based association studies have been combining successfully as the workhorses for hunting disease genes in the past decades and are performed concurrently. To attain an adequate balance between maximizing the chance of discovering potential disease-causing genes and minimizing the cost of study implementation, an optimal study design is necessary. Important issues on the basics of human genetics, principles of linkage analysis and association studies, advantages and limitations of individual strategies, as well as practical procedures in conducting disease gene mapping are discussed in detail. © 2008 Elsevier Ltd. All rights reserved.en_HK
dc.languageengen_US
dc.publisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/cuoren_HK
dc.relation.ispartofCurrent Orthopaedicsen_HK
dc.subjectcandidate gene approachen_HK
dc.subjectLinkage analysisen_HK
dc.title(ii) Family-based linkage and case control association studiesen_HK
dc.typeArticleen_HK
dc.identifier.emailChan, D: chand@hku.hken_HK
dc.identifier.emailCheung, KMC: cheungmc@hku.hken_HK
dc.identifier.emailSham, P: pcsham@hku.hken_HK
dc.identifier.emailSong, YQ: songy@hku.hken_HK
dc.identifier.authorityChan, D=rp00540en_HK
dc.identifier.authorityCheung, KMC=rp00387en_HK
dc.identifier.authoritySham, P=rp00459en_HK
dc.identifier.authoritySong, YQ=rp00488en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.cuor.2008.05.005en_HK
dc.identifier.scopuseid_2-s2.0-51249120075en_HK
dc.identifier.hkuros154521-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-51249120075&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume22en_HK
dc.identifier.issue4en_HK
dc.identifier.spage245en_HK
dc.identifier.epage250en_HK
dc.identifier.isiWOS:000260098200002-
dc.publisher.placeUnited Kingdomen_HK
dc.relation.projectDevelopmental genomics and skeletal research-
dc.identifier.scopusauthoridHo, DWH=23502006100en_HK
dc.identifier.scopusauthoridChan, D=7402216545en_HK
dc.identifier.scopusauthoridCheung, KMC=7402406754en_HK
dc.identifier.scopusauthoridSham, P=34573429300en_HK
dc.identifier.scopusauthoridSong, YQ=7404921212en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats