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Article: Power of transmission/disequilibrium tests in admixed populations

TitlePower of transmission/disequilibrium tests in admixed populations
Authors
KeywordsDisease susceptibility loci
Population admixture
Power
Transmission/disequilibrium test
Issue Date2008
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/35841
Citation
Genetic Epidemiology, 2008, v. 32 n. 5, p. 434-444 How to Cite?
AbstractThe power of transmission/disequilibrium tests (TDTs) for detecting disease susceptibility loci is expected to be influenced by population admixture through its impact on the degree of linkage disequilibrium (LD) between the genetic marker and the DSL. However, few studies have been done to systematically examine this behavior of the TDTs in admixed populations. In the present study, extensive computer simulations were conducted to explore how population admixture affects the power of TDTs. It was found that (1) in newly admixed populations, the LD due to admixture makes no contribution to the power of TDTs, and it is the averaged background LD in the parental populations that determines the power of TDTs; but (2) after random mating between the admixed populations, the LD due to admixture becomes effective in increasing or decreasing the power of the tests, and (3) incomplete random mating can prolong the time for the LD due to admixture to become effective. This study clarifies the potential influence of population admixture on the performance of TDTs. © 2008 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/147588
ISSN
2015 Impact Factor: 2.553
2015 SCImago Journal Rankings: 2.101
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLi, MXen_HK
dc.contributor.authorJiang, Len_HK
dc.contributor.authorSong, YQen_HK
dc.contributor.authorSham, PCen_HK
dc.date.accessioned2012-05-29T06:04:48Z-
dc.date.available2012-05-29T06:04:48Z-
dc.date.issued2008en_HK
dc.identifier.citationGenetic Epidemiology, 2008, v. 32 n. 5, p. 434-444en_HK
dc.identifier.issn0741-0395en_HK
dc.identifier.urihttp://hdl.handle.net/10722/147588-
dc.description.abstractThe power of transmission/disequilibrium tests (TDTs) for detecting disease susceptibility loci is expected to be influenced by population admixture through its impact on the degree of linkage disequilibrium (LD) between the genetic marker and the DSL. However, few studies have been done to systematically examine this behavior of the TDTs in admixed populations. In the present study, extensive computer simulations were conducted to explore how population admixture affects the power of TDTs. It was found that (1) in newly admixed populations, the LD due to admixture makes no contribution to the power of TDTs, and it is the averaged background LD in the parental populations that determines the power of TDTs; but (2) after random mating between the admixed populations, the LD due to admixture becomes effective in increasing or decreasing the power of the tests, and (3) incomplete random mating can prolong the time for the LD due to admixture to become effective. This study clarifies the potential influence of population admixture on the performance of TDTs. © 2008 Wiley-Liss, Inc.en_HK
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/35841en_HK
dc.relation.ispartofGenetic Epidemiologyen_HK
dc.subjectDisease susceptibility locien_HK
dc.subjectPopulation admixtureen_HK
dc.subjectPoweren_HK
dc.subjectTransmission/disequilibrium testen_HK
dc.subject.meshComputer Simulationen_US
dc.subject.meshGenetic Markersen_US
dc.subject.meshGenetic Predisposition To Diseaseen_US
dc.subject.meshGenetics, Populationen_US
dc.subject.meshHumansen_US
dc.subject.meshLinkage Disequilibriumen_US
dc.subject.meshModels, Geneticen_US
dc.subject.meshPopulationen_US
dc.titlePower of transmission/disequilibrium tests in admixed populationsen_HK
dc.typeArticleen_HK
dc.identifier.emailLi, MX: mxli@hku.hken_HK
dc.identifier.emailSong, YQ: songy@hku.hken_HK
dc.identifier.emailSham, PC: pcsham@hku.hken_HK
dc.identifier.authorityLi, MX=rp01722en_HK
dc.identifier.authoritySong, YQ=rp00488en_HK
dc.identifier.authoritySham, PC=rp00459en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/gepi.20316en_HK
dc.identifier.pmid18278814-
dc.identifier.scopuseid_2-s2.0-48949118897en_HK
dc.identifier.hkuros145496-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-48949118897&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume32en_HK
dc.identifier.issue5en_HK
dc.identifier.spage434en_HK
dc.identifier.epage444en_HK
dc.identifier.isiWOS:000257548000005-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLi, MX=17135391100en_HK
dc.identifier.scopusauthoridJiang, L=23012303800en_HK
dc.identifier.scopusauthoridSong, YQ=7404921212en_HK
dc.identifier.scopusauthoridSham, PC=34573429300en_HK

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