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Article: Systematic review on the efficacy and safety of herbal medicines for Alzheimer's disease

TitleSystematic review on the efficacy and safety of herbal medicines for Alzheimer's disease
Authors
Issue Date2008
PublisherIOS Press. The Journal's web site is located at http://www.iospress.nl/html/13872877.php
Citation
Journal of Alzheimer's Disease, 2008, v. 14 n. 2, p. 209-223 How to Cite?
AbstractA systematic review was conducted to assess the efficacy and safety of herbal medications (HM), as either monotherapy or adjunct to orthodox medications (cholinesterase inhibitors and nootropic agents, OM) for Alzheimer's disease (AD). Sixteen studies testing different HM were included. Out of the 15 HM monotherapy studies, 13 reported HM to be significantly better than OM or placebo; one reported similar efficacy between HM and OM. Only the HM adjuvant study reported significant efficacy. No major adverse events for HM were reported and HMs were found to reduce the adverse effects arising from OM. Imbalance in ethnicity among participants was observed; gender distribution was unclear. Heterogeneity in diagnostic criteria, interventions and outcome measures hindered comprehensive data analysis. Studies comparing HM with OM suggest that HM can be a safe, effective treatment for AD, either alone or in conjunction with OM. Methodological flaws in the design of the studies, however, limited the extent to which the results could be interpreted. Among various HMs, the safety and tolerability of EGb761 was best established. Further multi-center trials with large sample size, high methodological qualities and standardized HM ingredients are necessary for clinical recommendations on the use of HM in treating AD. © 2008 - IOS Press and the authors. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/147587
ISSN
2015 Impact Factor: 3.92
2015 SCImago Journal Rankings: 1.774
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMan, SCen_US
dc.contributor.authorDurairajan, SSKen_US
dc.contributor.authorKum, WFen_US
dc.contributor.authorLu, JHen_US
dc.contributor.authorHuang, JDen_US
dc.contributor.authorCheng, CFen_US
dc.contributor.authorChung, Ven_US
dc.contributor.authorXu, Men_US
dc.contributor.authorLi, Men_US
dc.date.accessioned2012-05-29T06:04:48Z-
dc.date.available2012-05-29T06:04:48Z-
dc.date.issued2008en_US
dc.identifier.citationJournal of Alzheimer's Disease, 2008, v. 14 n. 2, p. 209-223en_US
dc.identifier.issn1387-2877en_US
dc.identifier.urihttp://hdl.handle.net/10722/147587-
dc.description.abstractA systematic review was conducted to assess the efficacy and safety of herbal medications (HM), as either monotherapy or adjunct to orthodox medications (cholinesterase inhibitors and nootropic agents, OM) for Alzheimer's disease (AD). Sixteen studies testing different HM were included. Out of the 15 HM monotherapy studies, 13 reported HM to be significantly better than OM or placebo; one reported similar efficacy between HM and OM. Only the HM adjuvant study reported significant efficacy. No major adverse events for HM were reported and HMs were found to reduce the adverse effects arising from OM. Imbalance in ethnicity among participants was observed; gender distribution was unclear. Heterogeneity in diagnostic criteria, interventions and outcome measures hindered comprehensive data analysis. Studies comparing HM with OM suggest that HM can be a safe, effective treatment for AD, either alone or in conjunction with OM. Methodological flaws in the design of the studies, however, limited the extent to which the results could be interpreted. Among various HMs, the safety and tolerability of EGb761 was best established. Further multi-center trials with large sample size, high methodological qualities and standardized HM ingredients are necessary for clinical recommendations on the use of HM in treating AD. © 2008 - IOS Press and the authors. All rights reserved.en_US
dc.languageengen_US
dc.publisherIOS Press. The Journal's web site is located at http://www.iospress.nl/html/13872877.phpen_US
dc.relation.ispartofJournal of Alzheimer's Diseaseen_US
dc.subject.meshAlzheimer Disease - Drug Therapyen_US
dc.subject.meshCholinesterase Inhibitors - Therapeutic Useen_US
dc.subject.meshDrug Therapy, Combinationen_US
dc.subject.meshHumansen_US
dc.subject.meshNootropic Agents - Therapeutic Useen_US
dc.subject.meshPhytotherapyen_US
dc.subject.meshPlant Preparations - Adverse Effects - Therapeutic Useen_US
dc.subject.meshPlants, Medicinalen_US
dc.subject.meshRandomized Controlled Trials As Topicen_US
dc.subject.meshTreatment Outcomeen_US
dc.titleSystematic review on the efficacy and safety of herbal medicines for Alzheimer's diseaseen_US
dc.typeArticleen_US
dc.identifier.emailHuang, JD:jdhuang@hkucc.hku.hken_US
dc.identifier.authorityHuang, JD=rp00451en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid18560132-
dc.identifier.scopuseid_2-s2.0-47849090239en_US
dc.identifier.hkuros146697-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-47849090239&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume14en_US
dc.identifier.issue2en_US
dc.identifier.spage209en_US
dc.identifier.epage223en_US
dc.identifier.isiWOS:000256624400009-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridMan, SC=24476503900en_US
dc.identifier.scopusauthoridDurairajan, SSK=23469201000en_US
dc.identifier.scopusauthoridKum, WF=15063144400en_US
dc.identifier.scopusauthoridLu, JH=16175647100en_US
dc.identifier.scopusauthoridHuang, JD=8108660600en_US
dc.identifier.scopusauthoridCheng, CF=24476069500en_US
dc.identifier.scopusauthoridChung, V=8685594600en_US
dc.identifier.scopusauthoridXu, M=7403607541en_US
dc.identifier.scopusauthoridLi, M=36071647500en_US

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