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Article: β-ionone suppresses mammary carcinogenesis, proliferative activity and induces apoptosis in the mammary gland of the Sprague-Dawley rat

Titleβ-ionone suppresses mammary carcinogenesis, proliferative activity and induces apoptosis in the mammary gland of the Sprague-Dawley rat
Authors
Issue Date2008
PublisherJohn Wiley & Sons, Inc.. The Journal's web site is located at http://www3.interscience.wiley.com/journal/29331/home
Citation
International Journal Of Cancer, 2008, v. 122 n. 12, p. 2689-2698 How to Cite?
Abstractβ-Ionone demonstrates potent anticancer activity both in vitro and in vivo. We determined tumor incidence and the number of rats bearing tumors as well as cell proliferation and apoptosis in a rat mammary cancer model induced by 7, 12-dimethylbenz[a]anthracene (DMBA). Rats were fed an AIN-76A diet containing β-ionone (0, 9, 18 or 36 mmol/kg), starting 2 weeks before DMBA administration and continuing for 24 weeks. A dose-dependent inhibition of mammary carcinogenesis by dietary β-ionone was observed. Corresponding tumor incidence values were 82.1, 53.3, 25.9 and 10.0% (p < 0.01 or 0.05). Time to tumor appearance increased and tumor multiplicity decreased with increasing dietary β-ionone. Histopathological and immunohistochemical evaluations of tumors were performed on the 64, 31, 15 and 3 tumors, respectively, identified in rats from the respective groups of 30. The proportions of adenocarcinomas, adenomas and benign masses were equally distributed in the latter group. In proportions within the other groups, the proportions of adenocarcinomas and benign masses decreased and increased with increasing dietary β-ionone. Proliferating cell nuclear antigen (PCNA), cyclin D1 and Bcl-2 expression decreased, and Bax expression and nuclear fragmentation increased with increasing dietary β-ionone. These results demonstrate the potent capacity of dietary β-ionone to suppress DMBA-initiated mammary cancer in rats. © 2008 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/147575
ISSN
2015 Impact Factor: 5.531
2015 SCImago Journal Rankings: 2.657
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLiu, JRen_US
dc.contributor.authorSun, XRen_US
dc.contributor.authorDong, HWen_US
dc.contributor.authorSun, CHen_US
dc.contributor.authorSun, WGen_US
dc.contributor.authorChen, BQen_US
dc.contributor.authorSong, YQen_US
dc.contributor.authorYang, BFen_US
dc.date.accessioned2012-05-29T06:04:43Z-
dc.date.available2012-05-29T06:04:43Z-
dc.date.issued2008en_US
dc.identifier.citationInternational Journal Of Cancer, 2008, v. 122 n. 12, p. 2689-2698en_US
dc.identifier.issn0020-7136en_US
dc.identifier.urihttp://hdl.handle.net/10722/147575-
dc.description.abstractβ-Ionone demonstrates potent anticancer activity both in vitro and in vivo. We determined tumor incidence and the number of rats bearing tumors as well as cell proliferation and apoptosis in a rat mammary cancer model induced by 7, 12-dimethylbenz[a]anthracene (DMBA). Rats were fed an AIN-76A diet containing β-ionone (0, 9, 18 or 36 mmol/kg), starting 2 weeks before DMBA administration and continuing for 24 weeks. A dose-dependent inhibition of mammary carcinogenesis by dietary β-ionone was observed. Corresponding tumor incidence values were 82.1, 53.3, 25.9 and 10.0% (p < 0.01 or 0.05). Time to tumor appearance increased and tumor multiplicity decreased with increasing dietary β-ionone. Histopathological and immunohistochemical evaluations of tumors were performed on the 64, 31, 15 and 3 tumors, respectively, identified in rats from the respective groups of 30. The proportions of adenocarcinomas, adenomas and benign masses were equally distributed in the latter group. In proportions within the other groups, the proportions of adenocarcinomas and benign masses decreased and increased with increasing dietary β-ionone. Proliferating cell nuclear antigen (PCNA), cyclin D1 and Bcl-2 expression decreased, and Bax expression and nuclear fragmentation increased with increasing dietary β-ionone. These results demonstrate the potent capacity of dietary β-ionone to suppress DMBA-initiated mammary cancer in rats. © 2008 Wiley-Liss, Inc.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc.. The Journal's web site is located at http://www3.interscience.wiley.com/journal/29331/homeen_US
dc.relation.ispartofInternational Journal of Canceren_US
dc.subject.mesh9,10-Dimethyl-1,2-Benzanthracene - Toxicityen_US
dc.subject.meshAnimalsen_US
dc.subject.meshApoptosis - Drug Effectsen_US
dc.subject.meshBody Weight - Drug Effectsen_US
dc.subject.meshCarcinogens - Toxicityen_US
dc.subject.meshCell Proliferation - Drug Effectsen_US
dc.subject.meshCyclin D1 - Metabolismen_US
dc.subject.meshFemaleen_US
dc.subject.meshMammary Neoplasms, Experimental - Chemically Induced - Metabolism - Pathology - Prevention & Controlen_US
dc.subject.meshNorisoprenoids - Pharmacologyen_US
dc.subject.meshProliferating Cell Nuclear Antigen - Metabolismen_US
dc.subject.meshProto-Oncogene Proteins C-Bcl-2 - Metabolismen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.titleβ-ionone suppresses mammary carcinogenesis, proliferative activity and induces apoptosis in the mammary gland of the Sprague-Dawley raten_US
dc.typeArticleen_US
dc.identifier.emailSong, YQ:songy@hkucc.hku.hken_US
dc.identifier.authoritySong, YQ=rp00488en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/ijc.23453en_US
dc.identifier.pmid18386789-
dc.identifier.scopuseid_2-s2.0-43049149792en_US
dc.identifier.hkuros145498-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-43049149792&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume122en_US
dc.identifier.issue12en_US
dc.identifier.spage2689en_US
dc.identifier.epage2698en_US
dc.identifier.isiWOS:000256713800006-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLiu, JR=26637082300en_US
dc.identifier.scopusauthoridSun, XR=12798941300en_US
dc.identifier.scopusauthoridDong, HW=35749869200en_US
dc.identifier.scopusauthoridSun, CH=7404248892en_US
dc.identifier.scopusauthoridSun, WG=7404001354en_US
dc.identifier.scopusauthoridChen, BQ=25647470000en_US
dc.identifier.scopusauthoridSong, YQ=7404921212en_US
dc.identifier.scopusauthoridYang, BF=7404472748en_US

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