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Article: An immunolocalization study of tissue inhibitors of metalloproteinase-1 of bone graft healing on parietal bone

TitleAn immunolocalization study of tissue inhibitors of metalloproteinase-1 of bone graft healing on parietal bone
Authors
KeywordsBone graft
Osteogenesis
TIMP
Issue Date2008
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.jcraniofacialsurgery.com
Citation
Journal Of Craniofacial Surgery, 2008, v. 19 n. 2, p. 393-397 How to Cite?
AbstractThis immunolocalization study was performed to investigate the temporal and spatial expression of tissue inhibitors of metalloproteinase (TIMP) 1 within endochondral and intramembranous bone grafts during the early stages of healing, in the hope of gaining a better understanding of the mechanisms of bone graft healing, which could influence the choice of bone graft used. Twenty-seven adult New Zealand White rabbits were used as the experimental model. Autogenous bone grafts taken from the cranial bone (intramembranous in origin) and the femur (endochondral in origin) were grafted into skull defects created on either side of the parietal suture. Rabbits were killed on days 1 to 9 postgrafting, and the bone graft alone was harvested for immunolocalization of TIMP-1. In endochondral bone grafts, TIMP-1 was expressed on days 1 to 3, followed by a period of absence until days 8 and 9. Intramembranous bone grafts did not express TIMP-1 until days 6 to 9. The timing and location of TIMP-1 expression coincided with osteogenesis, which indicates a role for TIMP-1 in preserving newly formed bone during the initial stages of graft healing. The differential temporal expression of TIMP-1 in endochondral and intramembranous bone grafts suggests that bone graft type plays an important role in influencing the healing process mediated by the host tissues. The earlier expression of TIMP-1 in endochondral bone grafts could be the reason for delayed vascularization of defects containing these grafts, whereas the delayed expression of TIMP-1 in intramembranous bone grafts could allow earlier vascularization of the intramembranous bone grafts. ©2008Muntaz B. Habal, MD.
Persistent Identifierhttp://hdl.handle.net/10722/147572
ISSN
2015 Impact Factor: 0.7
2015 SCImago Journal Rankings: 0.443
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTwitty, Aen_HK
dc.contributor.authorRabie, ABMen_HK
dc.contributor.authorShum, DKYen_HK
dc.contributor.authorWong, RWKen_HK
dc.date.accessioned2012-05-29T06:04:42Z-
dc.date.available2012-05-29T06:04:42Z-
dc.date.issued2008en_HK
dc.identifier.citationJournal Of Craniofacial Surgery, 2008, v. 19 n. 2, p. 393-397en_HK
dc.identifier.issn1049-2275en_HK
dc.identifier.urihttp://hdl.handle.net/10722/147572-
dc.description.abstractThis immunolocalization study was performed to investigate the temporal and spatial expression of tissue inhibitors of metalloproteinase (TIMP) 1 within endochondral and intramembranous bone grafts during the early stages of healing, in the hope of gaining a better understanding of the mechanisms of bone graft healing, which could influence the choice of bone graft used. Twenty-seven adult New Zealand White rabbits were used as the experimental model. Autogenous bone grafts taken from the cranial bone (intramembranous in origin) and the femur (endochondral in origin) were grafted into skull defects created on either side of the parietal suture. Rabbits were killed on days 1 to 9 postgrafting, and the bone graft alone was harvested for immunolocalization of TIMP-1. In endochondral bone grafts, TIMP-1 was expressed on days 1 to 3, followed by a period of absence until days 8 and 9. Intramembranous bone grafts did not express TIMP-1 until days 6 to 9. The timing and location of TIMP-1 expression coincided with osteogenesis, which indicates a role for TIMP-1 in preserving newly formed bone during the initial stages of graft healing. The differential temporal expression of TIMP-1 in endochondral and intramembranous bone grafts suggests that bone graft type plays an important role in influencing the healing process mediated by the host tissues. The earlier expression of TIMP-1 in endochondral bone grafts could be the reason for delayed vascularization of defects containing these grafts, whereas the delayed expression of TIMP-1 in intramembranous bone grafts could allow earlier vascularization of the intramembranous bone grafts. ©2008Muntaz B. Habal, MD.en_HK
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.jcraniofacialsurgery.comen_HK
dc.relation.ispartofJournal of Craniofacial Surgeryen_HK
dc.subjectBone graften_HK
dc.subjectOsteogenesisen_HK
dc.subjectTIMPen_HK
dc.subject.meshAnimalsen_US
dc.subject.meshBone Diseases - Enzymology - Physiopathology - Surgeryen_US
dc.subject.meshBone Transplantation - Classification - Pathology - Physiologyen_US
dc.subject.meshColoring Agents - Diagnostic Useen_US
dc.subject.meshDisease Models, Animalen_US
dc.subject.meshGranulation Tissue - Enzymologyen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshOsteogenesis - Physiologyen_US
dc.subject.meshParietal Bone - Enzymology - Physiopathology - Surgeryen_US
dc.subject.meshRabbitsen_US
dc.subject.meshTime Factorsen_US
dc.subject.meshTissue Inhibitor Of Metalloproteinase-1 - Analysisen_US
dc.subject.meshWound Healing - Physiologyen_US
dc.titleAn immunolocalization study of tissue inhibitors of metalloproteinase-1 of bone graft healing on parietal boneen_HK
dc.typeArticleen_HK
dc.identifier.emailRabie, ABM: rabie@hku.hken_HK
dc.identifier.emailShum, DKY: shumdkhk@hkucc.hku.hken_HK
dc.identifier.emailWong, RWK: fyoung@hku.hken_HK
dc.identifier.authorityRabie, ABM=rp00029en_HK
dc.identifier.authorityShum, DKY=rp00321en_HK
dc.identifier.authorityWong, RWK=rp00038en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1097/SCS.0b013e318163f936en_HK
dc.identifier.pmid18362716-
dc.identifier.scopuseid_2-s2.0-42049119633en_HK
dc.identifier.hkuros143949-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-42049119633&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume19en_HK
dc.identifier.issue2en_HK
dc.identifier.spage393en_HK
dc.identifier.epage397en_HK
dc.identifier.isiWOS:000254494200017-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridTwitty, A=12345207900en_HK
dc.identifier.scopusauthoridRabie, ABM=7007172734en_HK
dc.identifier.scopusauthoridShum, DKY=7004824447en_HK
dc.identifier.scopusauthoridWong, RWK=7402127170en_HK

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