File Download
 
Links for fulltext
(May Require Subscription)
 
Supplementary

Article: Bismuth complexes inhibit the SARS coronavirus
  • Basic View
  • Metadata View
  • XML View
TitleBismuth complexes inhibit the SARS coronavirus
 
AuthorsYang, N1
Tanner, JA1
Zheng, BJ1
Watt, RM1
He, ML2
Lu, LY1
Jiang, JQ1
Shum, KT1
Lin, YP1
Wong, KL1
Lin, MCM1
Kung, HF2
Sun, H1
Huang, JD1
 
KeywordsAntiviral agents
Bismuth
Enzymes
Helical structures
SARS coronavirus
 
Issue Date2007
 
PublisherWiley - V C H Verlag GmbH & Co. KGaA. The Journal's web site is located at http://www3.interscience.wiley.com/journal/26737/home
 
CitationAngewandte Chemie - International Edition, 2007, v. 46 n. 34, p. 6464-6468 [How to Cite?]
DOI: http://dx.doi.org/10.1002/anie.200701021
 
AbstractHold tight: Bismuth complexes including ranitidine bismuth citrate effectively inhibit the nucleoside triphosphate hydrolase and DNA unwinding activities of the SARS coronavirus (SCV) helicase and dramatically reduce SCV replication levels in infected cells. This suggests that bismuth-based drugs should be further evaluated for the treatment of SCV infections in vivo. ss = single-stranded DNA, ds = duplex DNA. (Figure Presented). © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
 
ISSN1433-7851
2012 Impact Factor: 13.734
 
DOIhttp://dx.doi.org/10.1002/anie.200701021
 
ISI Accession Number IDWOS:000249296900014
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorYang, N
 
dc.contributor.authorTanner, JA
 
dc.contributor.authorZheng, BJ
 
dc.contributor.authorWatt, RM
 
dc.contributor.authorHe, ML
 
dc.contributor.authorLu, LY
 
dc.contributor.authorJiang, JQ
 
dc.contributor.authorShum, KT
 
dc.contributor.authorLin, YP
 
dc.contributor.authorWong, KL
 
dc.contributor.authorLin, MCM
 
dc.contributor.authorKung, HF
 
dc.contributor.authorSun, H
 
dc.contributor.authorHuang, JD
 
dc.date.accessioned2012-05-29T06:04:39Z
 
dc.date.available2012-05-29T06:04:39Z
 
dc.date.issued2007
 
dc.description.abstractHold tight: Bismuth complexes including ranitidine bismuth citrate effectively inhibit the nucleoside triphosphate hydrolase and DNA unwinding activities of the SARS coronavirus (SCV) helicase and dramatically reduce SCV replication levels in infected cells. This suggests that bismuth-based drugs should be further evaluated for the treatment of SCV infections in vivo. ss = single-stranded DNA, ds = duplex DNA. (Figure Presented). © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationAngewandte Chemie - International Edition, 2007, v. 46 n. 34, p. 6464-6468 [How to Cite?]
DOI: http://dx.doi.org/10.1002/anie.200701021
 
dc.identifier.citeulike3813564
 
dc.identifier.doihttp://dx.doi.org/10.1002/anie.200701021
 
dc.identifier.eissn1521-3773
 
dc.identifier.epage6468
 
dc.identifier.hkuros132927
 
dc.identifier.hkuros153291
 
dc.identifier.isiWOS:000249296900014
 
dc.identifier.issn1433-7851
2012 Impact Factor: 13.734
 
dc.identifier.issue34
 
dc.identifier.pmid17645269
 
dc.identifier.scopuseid_2-s2.0-34548306443
 
dc.identifier.spage6464
 
dc.identifier.urihttp://hdl.handle.net/10722/147565
 
dc.identifier.volume46
 
dc.languageeng
 
dc.publisherWiley - V C H Verlag GmbH & Co. KGaA. The Journal's web site is located at http://www3.interscience.wiley.com/journal/26737/home
 
dc.publisher.placeGermany
 
dc.relation.ispartofAngewandte Chemie - International Edition
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAdenosine Triphosphatases - Metabolism
 
dc.subject.meshAntiviral Agents - Chemical Synthesis - Pharmacology
 
dc.subject.meshBismuth - Chemistry - Pharmacology
 
dc.subject.meshCell Line
 
dc.subject.meshCysteine - Chemistry
 
dc.subject.meshDna Helicases - Antagonists & Inhibitors
 
dc.subject.meshEnzyme Inhibitors - Chemical Synthesis - Pharmacology
 
dc.subject.meshHumans
 
dc.subject.meshKinetics
 
dc.subject.meshNucleic Acid Conformation - Drug Effects
 
dc.subject.meshOrganometallic Compounds - Chemistry - Pharmacology
 
dc.subject.meshSars Virus - Drug Effects
 
dc.subject.meshVirus Replication - Drug Effects
 
dc.subjectAntiviral agents
 
dc.subjectBismuth
 
dc.subjectEnzymes
 
dc.subjectHelical structures
 
dc.subjectSARS coronavirus
 
dc.titleBismuth complexes inhibit the SARS coronavirus
 
dc.typeArticle
 
<?xml encoding="utf-8" version="1.0"?>
<item><contributor.author>Yang, N</contributor.author>
<contributor.author>Tanner, JA</contributor.author>
<contributor.author>Zheng, BJ</contributor.author>
<contributor.author>Watt, RM</contributor.author>
<contributor.author>He, ML</contributor.author>
<contributor.author>Lu, LY</contributor.author>
<contributor.author>Jiang, JQ</contributor.author>
<contributor.author>Shum, KT</contributor.author>
<contributor.author>Lin, YP</contributor.author>
<contributor.author>Wong, KL</contributor.author>
<contributor.author>Lin, MCM</contributor.author>
<contributor.author>Kung, HF</contributor.author>
<contributor.author>Sun, H</contributor.author>
<contributor.author>Huang, JD</contributor.author>
<date.accessioned>2012-05-29T06:04:39Z</date.accessioned>
<date.available>2012-05-29T06:04:39Z</date.available>
<date.issued>2007</date.issued>
<identifier.citation>Angewandte Chemie - International Edition, 2007, v. 46 n. 34, p. 6464-6468</identifier.citation>
<identifier.issn>1433-7851</identifier.issn>
<identifier.uri>http://hdl.handle.net/10722/147565</identifier.uri>
<description.abstract>Hold tight: Bismuth complexes including ranitidine bismuth citrate effectively inhibit the nucleoside triphosphate hydrolase and DNA unwinding activities of the SARS coronavirus (SCV) helicase and dramatically reduce SCV replication levels in infected cells. This suggests that bismuth-based drugs should be further evaluated for the treatment of SCV infections in vivo. ss = single-stranded DNA, ds = duplex DNA. (Figure Presented). &#169; 2007 Wiley-VCH Verlag GmbH &amp; Co. KGaA.</description.abstract>
<language>eng</language>
<publisher>Wiley - V C H Verlag GmbH &amp; Co. KGaA. The Journal&apos;s web site is located at http://www3.interscience.wiley.com/journal/26737/home</publisher>
<relation.ispartof>Angewandte Chemie - International Edition</relation.ispartof>
<subject>Antiviral agents</subject>
<subject>Bismuth</subject>
<subject>Enzymes</subject>
<subject>Helical structures</subject>
<subject>SARS coronavirus</subject>
<subject.mesh>Adenosine Triphosphatases - Metabolism</subject.mesh>
<subject.mesh>Antiviral Agents - Chemical Synthesis - Pharmacology</subject.mesh>
<subject.mesh>Bismuth - Chemistry - Pharmacology</subject.mesh>
<subject.mesh>Cell Line</subject.mesh>
<subject.mesh>Cysteine - Chemistry</subject.mesh>
<subject.mesh>Dna Helicases - Antagonists &amp; Inhibitors</subject.mesh>
<subject.mesh>Enzyme Inhibitors - Chemical Synthesis - Pharmacology</subject.mesh>
<subject.mesh>Humans</subject.mesh>
<subject.mesh>Kinetics</subject.mesh>
<subject.mesh>Nucleic Acid Conformation - Drug Effects</subject.mesh>
<subject.mesh>Organometallic Compounds - Chemistry - Pharmacology</subject.mesh>
<subject.mesh>Sars Virus - Drug Effects</subject.mesh>
<subject.mesh>Virus Replication - Drug Effects</subject.mesh>
<title>Bismuth complexes inhibit the SARS coronavirus</title>
<type>Article</type>
<description.nature>Link_to_subscribed_fulltext</description.nature>
<identifier.doi>10.1002/anie.200701021</identifier.doi>
<identifier.pmid>17645269</identifier.pmid>
<identifier.scopus>eid_2-s2.0-34548306443</identifier.scopus>
<identifier.hkuros>132927</identifier.hkuros>
<identifier.hkuros>153291</identifier.hkuros>
<relation.references>http://www.scopus.com/mlt/select.url?eid=2-s2.0-34548306443&amp;selection=ref&amp;src=s&amp;origin=recordpage</relation.references>
<identifier.volume>46</identifier.volume>
<identifier.issue>34</identifier.issue>
<identifier.spage>6464</identifier.spage>
<identifier.epage>6468</identifier.epage>
<identifier.eissn>1521-3773</identifier.eissn>
<identifier.isi>WOS:000249296900014</identifier.isi>
<publisher.place>Germany</publisher.place>
<identifier.citeulike>3813564</identifier.citeulike>
</item>
Author Affiliations
  1. The University of Hong Kong
  2. Chinese University of Hong Kong