Article: Bismuth complexes inhibit the SARS coronavirus

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TitleBismuth complexes inhibit the SARS coronavirus
AuthorsYang, N1
Tanner, JA1
Zheng, BJ1
Watt, RM1
He, ML2
Lu, LY1
Jiang, JQ1
Shum, KT1
Lin, YP1
Wong, KL1
Lin, MCM1
Kung, HF2
Sun, H1
Huang, JD1
KeywordsAntiviral agents
Bismuth
Enzymes
Helical structures
SARS coronavirus
Issue Date2007
PublisherWiley - V C H Verlag GmbH & Co. KGaA. The Journal's web site is located at http://www3.interscience.wiley.com/journal/26737/home
CitationAngewandte Chemie - International Edition, 2007, v. 46 n. 34, p. 6464-6468 [How to Cite?]
DOI: http://dx.doi.org/10.1002/anie.200701021
AbstractHold tight: Bismuth complexes including ranitidine bismuth citrate effectively inhibit the nucleoside triphosphate hydrolase and DNA unwinding activities of the SARS coronavirus (SCV) helicase and dramatically reduce SCV replication levels in infected cells. This suggests that bismuth-based drugs should be further evaluated for the treatment of SCV infections in vivo. ss = single-stranded DNA, ds = duplex DNA. (Figure Presented). © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
ISSN1433-7851
2011 Impact Factor: 13.455
DOIhttp://dx.doi.org/10.1002/anie.200701021
ISI Accession Number IDWOS:000249296900014
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorYang, N
dc.contributor.authorTanner, JA
dc.contributor.authorZheng, BJ
dc.contributor.authorWatt, RM
dc.contributor.authorHe, ML
dc.contributor.authorLu, LY
dc.contributor.authorJiang, JQ
dc.contributor.authorShum, KT
dc.contributor.authorLin, YP
dc.contributor.authorWong, KL
dc.contributor.authorLin, MCM
dc.contributor.authorKung, HF
dc.contributor.authorSun, H
dc.contributor.authorHuang, JD
dc.date.accessioned2012-05-29T06:04:39Z
dc.date.available2012-05-29T06:04:39Z
dc.date.issued2007
dc.description.abstractHold tight: Bismuth complexes including ranitidine bismuth citrate effectively inhibit the nucleoside triphosphate hydrolase and DNA unwinding activities of the SARS coronavirus (SCV) helicase and dramatically reduce SCV replication levels in infected cells. This suggests that bismuth-based drugs should be further evaluated for the treatment of SCV infections in vivo. ss = single-stranded DNA, ds = duplex DNA. (Figure Presented). © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationAngewandte Chemie - International Edition, 2007, v. 46 n. 34, p. 6464-6468 [How to Cite?]
DOI: http://dx.doi.org/10.1002/anie.200701021
dc.identifier.citeulike3813564
dc.identifier.doihttp://dx.doi.org/10.1002/anie.200701021
dc.identifier.epage6468
dc.identifier.hkuros132927
dc.identifier.hkuros153291
dc.identifier.isiWOS:000249296900014
dc.identifier.issn1433-7851
2011 Impact Factor: 13.455
dc.identifier.issue34
dc.identifier.pmid17645269
dc.identifier.scopuseid_2-s2.0-34548306443
dc.identifier.spage6464
dc.identifier.urihttp://hdl.handle.net/10722/147565
dc.identifier.volume46
dc.languageeng
dc.publisherWiley - V C H Verlag GmbH & Co. KGaA. The Journal's web site is located at http://www3.interscience.wiley.com/journal/26737/home
dc.publisher.placeGermany
dc.relation.ispartofAngewandte Chemie - International Edition
dc.relation.referencesReferences in Scopus
dc.subject.meshAdenosine Triphosphatases - Metabolism
dc.subject.meshAntiviral Agents - Chemical Synthesis - Pharmacology
dc.subject.meshBismuth - Chemistry - Pharmacology
dc.subject.meshCell Line
dc.subject.meshCysteine - Chemistry
dc.subject.meshDna Helicases - Antagonists & Inhibitors
dc.subject.meshEnzyme Inhibitors - Chemical Synthesis - Pharmacology
dc.subject.meshHumans
dc.subject.meshKinetics
dc.subject.meshNucleic Acid Conformation - Drug Effects
dc.subject.meshOrganometallic Compounds - Chemistry - Pharmacology
dc.subject.meshSars Virus - Drug Effects
dc.subject.meshVirus Replication - Drug Effects
dc.subjectAntiviral agents
dc.subjectBismuth
dc.subjectEnzymes
dc.subjectHelical structures
dc.subjectSARS coronavirus
dc.titleBismuth complexes inhibit the SARS coronavirus
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong
  2. Chinese University of Hong Kong