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Article: Bismuth complexes inhibit the SARS coronavirus

TitleBismuth complexes inhibit the SARS coronavirus
Authors
KeywordsAntiviral agents
Bismuth
Enzymes
Helical structures
SARS coronavirus
Issue Date2007
PublisherWiley - V C H Verlag GmbH & Co. KGaA. The Journal's web site is located at http://www3.interscience.wiley.com/journal/26737/home
Citation
Angewandte Chemie - International Edition, 2007, v. 46 n. 34, p. 6464-6468 How to Cite?
AbstractHold tight: Bismuth complexes including ranitidine bismuth citrate effectively inhibit the nucleoside triphosphate hydrolase and DNA unwinding activities of the SARS coronavirus (SCV) helicase and dramatically reduce SCV replication levels in infected cells. This suggests that bismuth-based drugs should be further evaluated for the treatment of SCV infections in vivo. ss = single-stranded DNA, ds = duplex DNA. (Figure Presented). © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
Persistent Identifierhttp://hdl.handle.net/10722/147565
ISSN
2014 Impact Factor: 11.261
2014 SCImago Journal Rankings: 5.149
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYang, Nen_HK
dc.contributor.authorTanner, JAen_HK
dc.contributor.authorZheng, BJen_HK
dc.contributor.authorWatt, RMen_HK
dc.contributor.authorHe, MLen_HK
dc.contributor.authorLu, LYen_HK
dc.contributor.authorJiang, JQen_HK
dc.contributor.authorShum, KTen_HK
dc.contributor.authorLin, YPen_HK
dc.contributor.authorWong, KLen_HK
dc.contributor.authorLin, MCMen_HK
dc.contributor.authorKung, HFen_HK
dc.contributor.authorSun, Hen_HK
dc.contributor.authorHuang, JDen_HK
dc.date.accessioned2012-05-29T06:04:39Z-
dc.date.available2012-05-29T06:04:39Z-
dc.date.issued2007en_HK
dc.identifier.citationAngewandte Chemie - International Edition, 2007, v. 46 n. 34, p. 6464-6468en_HK
dc.identifier.issn1433-7851en_HK
dc.identifier.urihttp://hdl.handle.net/10722/147565-
dc.description.abstractHold tight: Bismuth complexes including ranitidine bismuth citrate effectively inhibit the nucleoside triphosphate hydrolase and DNA unwinding activities of the SARS coronavirus (SCV) helicase and dramatically reduce SCV replication levels in infected cells. This suggests that bismuth-based drugs should be further evaluated for the treatment of SCV infections in vivo. ss = single-stranded DNA, ds = duplex DNA. (Figure Presented). © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.en_HK
dc.languageengen_US
dc.publisherWiley - V C H Verlag GmbH & Co. KGaA. The Journal's web site is located at http://www3.interscience.wiley.com/journal/26737/homeen_HK
dc.relation.ispartofAngewandte Chemie - International Editionen_HK
dc.subjectAntiviral agentsen_HK
dc.subjectBismuthen_HK
dc.subjectEnzymesen_HK
dc.subjectHelical structuresen_HK
dc.subjectSARS coronavirusen_HK
dc.subject.meshAdenosine Triphosphatases - Metabolismen_US
dc.subject.meshAntiviral Agents - Chemical Synthesis - Pharmacologyen_US
dc.subject.meshBismuth - Chemistry - Pharmacologyen_US
dc.subject.meshCell Lineen_US
dc.subject.meshCysteine - Chemistryen_US
dc.subject.meshDna Helicases - Antagonists & Inhibitorsen_US
dc.subject.meshEnzyme Inhibitors - Chemical Synthesis - Pharmacologyen_US
dc.subject.meshHumansen_US
dc.subject.meshKineticsen_US
dc.subject.meshNucleic Acid Conformation - Drug Effectsen_US
dc.subject.meshOrganometallic Compounds - Chemistry - Pharmacologyen_US
dc.subject.meshSars Virus - Drug Effectsen_US
dc.subject.meshVirus Replication - Drug Effectsen_US
dc.titleBismuth complexes inhibit the SARS coronavirusen_HK
dc.typeArticleen_HK
dc.identifier.emailTanner, JA:jatanner@hku.hken_HK
dc.identifier.emailZheng, BJ:bzheng@hkucc.hku.hken_HK
dc.identifier.emailWatt, RM:rmwatt@hku.hken_HK
dc.identifier.emailLin, MCM:mcllin@hkucc.hku.hken_HK
dc.identifier.emailSun, H:hsun@hkucc.hku.hken_HK
dc.identifier.emailHuang, JD:jdhuang@hkucc.hku.hken_HK
dc.identifier.authorityTanner, JA=rp00495en_HK
dc.identifier.authorityZheng, BJ=rp00353en_HK
dc.identifier.authorityWatt, RM=rp00043en_HK
dc.identifier.authorityLin, MCM=rp00746en_HK
dc.identifier.authoritySun, H=rp00777en_HK
dc.identifier.authorityHuang, JD=rp00451en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/anie.200701021en_HK
dc.identifier.pmid17645269en_HK
dc.identifier.scopuseid_2-s2.0-34548306443en_HK
dc.identifier.hkuros132927-
dc.identifier.hkuros153291-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34548306443&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume46en_HK
dc.identifier.issue34en_HK
dc.identifier.spage6464en_HK
dc.identifier.epage6468en_HK
dc.identifier.eissn1521-3773-
dc.identifier.isiWOS:000249296900014-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridYang, N=36633600500en_HK
dc.identifier.scopusauthoridTanner, JA=35513993000en_HK
dc.identifier.scopusauthoridZheng, BJ=7201780588en_HK
dc.identifier.scopusauthoridWatt, RM=7102907536en_HK
dc.identifier.scopusauthoridHe, ML=35080389700en_HK
dc.identifier.scopusauthoridLu, LY=8686996700en_HK
dc.identifier.scopusauthoridJiang, JQ=8591934900en_HK
dc.identifier.scopusauthoridShum, KT=20436474600en_HK
dc.identifier.scopusauthoridLin, YP=8591935100en_HK
dc.identifier.scopusauthoridWong, KL=7404758889en_HK
dc.identifier.scopusauthoridLin, MCM=7404816359en_HK
dc.identifier.scopusauthoridKung, HF=7402514190en_HK
dc.identifier.scopusauthoridSun, H=7404827446en_HK
dc.identifier.scopusauthoridHuang, JD=8108660600en_HK
dc.identifier.citeulike3813564-

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