File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Down regulation of a novel proliferation responded gene in human breast cancer

TitleDown regulation of a novel proliferation responded gene in human breast cancer
Authors
Issue Date1997
PublisherFederation of American Societies for Experimental Biology. The Journal's web site is located at http://www.fasebj.org/
Citation
Faseb Journal, 1997, v. 11 n. 9, p. A1430 How to Cite?
AbstractUsing RNA differential display we have recently cloned a gene(SERG)expressed at earlier stage of serum stimulation from human colon cancer line WiDr. The level of expression of SERG gene was elevated 30 minutes after serum was introduced to the starved cells. SERG gene was expressed differently in various human tissues. The higher expression was found in tissues of spleen,colon,liver,prostate,skeletal muscle,liver,lung and peripheral blood leukocyte, while very low expression in that of brain,ovary and testis. Interestingly among 15 human breast cancer cell lines, only three cell lines with low malignancy(MCF-10,AIN-4,HBL-100) differently expressed SERG gene, while others(MDA-231, MDA-463, MCF-7, T47-D, U-1180, BL-2, ZR-75, MDA-231Ewa, CTLL, Chang, V937, HDF) had no detectable expression. Since SERG is a serum stimulation responded gene,it might mean that during breast malignancy, breast cancer cells become less growth factor dependent and SERG gene is down regulated. The question whether this gene is also down regulated in other tnmors is now under investigation.
Persistent Identifierhttp://hdl.handle.net/10722/147551
ISSN
2015 Impact Factor: 5.299
2015 SCImago Journal Rankings: 2.775

 

DC FieldValueLanguage
dc.contributor.authorZhou, Zen_US
dc.contributor.authorWang, Jen_US
dc.contributor.authorLinder, Sen_US
dc.contributor.authorVarsanyi, Men_US
dc.date.accessioned2012-05-29T06:04:31Z-
dc.date.available2012-05-29T06:04:31Z-
dc.date.issued1997en_US
dc.identifier.citationFaseb Journal, 1997, v. 11 n. 9, p. A1430en_US
dc.identifier.issn0892-6638en_US
dc.identifier.urihttp://hdl.handle.net/10722/147551-
dc.description.abstractUsing RNA differential display we have recently cloned a gene(SERG)expressed at earlier stage of serum stimulation from human colon cancer line WiDr. The level of expression of SERG gene was elevated 30 minutes after serum was introduced to the starved cells. SERG gene was expressed differently in various human tissues. The higher expression was found in tissues of spleen,colon,liver,prostate,skeletal muscle,liver,lung and peripheral blood leukocyte, while very low expression in that of brain,ovary and testis. Interestingly among 15 human breast cancer cell lines, only three cell lines with low malignancy(MCF-10,AIN-4,HBL-100) differently expressed SERG gene, while others(MDA-231, MDA-463, MCF-7, T47-D, U-1180, BL-2, ZR-75, MDA-231Ewa, CTLL, Chang, V937, HDF) had no detectable expression. Since SERG is a serum stimulation responded gene,it might mean that during breast malignancy, breast cancer cells become less growth factor dependent and SERG gene is down regulated. The question whether this gene is also down regulated in other tnmors is now under investigation.en_US
dc.languageengen_US
dc.publisherFederation of American Societies for Experimental Biology. The Journal's web site is located at http://www.fasebj.org/en_US
dc.relation.ispartofFASEB Journalen_US
dc.titleDown regulation of a novel proliferation responded gene in human breast canceren_US
dc.typeArticleen_US
dc.identifier.emailZhou, Z:zhongjun@hkucc.hku.hken_US
dc.identifier.authorityZhou, Z=rp00503en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-33750237144en_US
dc.identifier.volume11en_US
dc.identifier.issue9en_US
dc.identifier.spageA1430en_US
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridZhou, Z=8631856300en_US
dc.identifier.scopusauthoridWang, J=8631854400en_US
dc.identifier.scopusauthoridLinder, S=7103323193en_US
dc.identifier.scopusauthoridVarsanyi, M=14021765800en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats