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Article: Regulation of heparanase gene expression and endoglucuronidase activity: Implication in cell invasion and metastasis

TitleRegulation of heparanase gene expression and endoglucuronidase activity: Implication in cell invasion and metastasis
Authors
KeywordsCell Invasion
Endoglucuronidase Activity
Gene Regulation
Heparan Sulfate Proteoglycans
Heparanase
Metastasis
Issue Date2005
Citation
Progress In Biochemistry And Biophysics, 2005, v. 32 n. 9, p. 817-821 How to Cite?
AbstractHeparanase is the only mammalian endo-β -D-glucuronidase known to cleave heparan sulfate (HS) components of proteoglycans(PGs) at limited intra-chain sites. Heparanase release in response to an inflammatory stimulus or in relation to tumor metastasis alters the composition and structural integrity of extracellular matrix and basement membrane. The enzymatic degradation of HS by heparanase is, therefore, involved in range of biological phenomena, from pregnancy, morphogenesis and development to inflammation, vascularization, and cancer progression. In normal physiological processes, expression of the active enzyme is tightly regulated by promoter methylation, mRNA splicing, transcription factors, proteolytic processing and inflammatory cytokines. The recent findings about the strict regulation of heparanase from the expression of the gene to processing of the protein product to yield the active enzyme are reviewed.
Persistent Identifierhttp://hdl.handle.net/10722/147529
ISSN
2015 Impact Factor: 0.224
2015 SCImago Journal Rankings: 0.138
References

 

DC FieldValueLanguage
dc.contributor.authorZhang, Yen_US
dc.contributor.authorShum, DKYen_US
dc.date.accessioned2012-05-29T06:04:23Z-
dc.date.available2012-05-29T06:04:23Z-
dc.date.issued2005en_US
dc.identifier.citationProgress In Biochemistry And Biophysics, 2005, v. 32 n. 9, p. 817-821en_US
dc.identifier.issn1000-3282en_US
dc.identifier.urihttp://hdl.handle.net/10722/147529-
dc.description.abstractHeparanase is the only mammalian endo-β -D-glucuronidase known to cleave heparan sulfate (HS) components of proteoglycans(PGs) at limited intra-chain sites. Heparanase release in response to an inflammatory stimulus or in relation to tumor metastasis alters the composition and structural integrity of extracellular matrix and basement membrane. The enzymatic degradation of HS by heparanase is, therefore, involved in range of biological phenomena, from pregnancy, morphogenesis and development to inflammation, vascularization, and cancer progression. In normal physiological processes, expression of the active enzyme is tightly regulated by promoter methylation, mRNA splicing, transcription factors, proteolytic processing and inflammatory cytokines. The recent findings about the strict regulation of heparanase from the expression of the gene to processing of the protein product to yield the active enzyme are reviewed.en_US
dc.languageengen_US
dc.relation.ispartofProgress in Biochemistry and Biophysicsen_US
dc.subjectCell Invasionen_US
dc.subjectEndoglucuronidase Activityen_US
dc.subjectGene Regulationen_US
dc.subjectHeparan Sulfate Proteoglycansen_US
dc.subjectHeparanaseen_US
dc.subjectMetastasisen_US
dc.titleRegulation of heparanase gene expression and endoglucuronidase activity: Implication in cell invasion and metastasisen_US
dc.typeArticleen_US
dc.identifier.emailShum, DKY:shumdkhk@hkucc.hku.hken_US
dc.identifier.authorityShum, DKY=rp00321en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-29344448520en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-29344448520&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume32en_US
dc.identifier.issue9en_US
dc.identifier.spage817en_US
dc.identifier.epage821en_US
dc.publisher.placeChinaen_US
dc.identifier.scopusauthoridZhang, Y=22995994100en_US
dc.identifier.scopusauthoridShum, DKY=7004824447en_US

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