File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Insulin-like growth factors 1 and 2 induce lymphangiogenesis in vivo

TitleInsulin-like growth factors 1 and 2 induce lymphangiogenesis in vivo
Authors
Issue Date2005
PublisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.org
Citation
Proceedings Of The National Academy Of Sciences Of The United States Of America, 2005, v. 102 n. 43, p. 15593-15598 How to Cite?
AbstractLymphangiogenesis is an important process that contributes to the spread of cancer. Here we show that insulin-like growth factors 1 (IGF-1) and 2 (IGF-2) induce lymphangiogenesis in vivo. In a mouse cornea assay, IGF-1 and IGF-2 induce lymphangiogenesis as detected with LYVE-1, a specific marker for lymphatic endothelium. Interestingly, IGF-1-induced lymphangiogenesis could not be blocked by a soluble vascular endothelial growth factor receptor 3, suggesting that the vascular endothelial growth factor receptor 3-signaling pathway is not required for IGF-induced lymphangiogenesis. In vitro, IGF-1 and IGF-2 significantly stimulated proliferation and migration of primary lymphatic endothelial cells. IGF-1 and IGF-2 induced phosphorylation of intracellular signaling components, such as Akt, Src, and extracellular signal-regulated kinase in lymphatic endothelial cells, Immunohistochemistry, RT-PCR, and Affymetrix GeneChip microarray analysis showed that the receptors for IGFs are present in lymphatic endothelium. Together, our findings suggest that IGFs might act as direct lymphangiogenic factors, although any indirect roles in the induction of lymphangiogenesis cannot be excluded. Because members of the IGF ligand and receptor families are widely expressed in various types of solid tumors, our findings suggest that these factors are likely to contribute to lymphatic metastasis. © 2005 by The National Academy of Sciences of the USA.
Persistent Identifierhttp://hdl.handle.net/10722/147526
ISSN
2015 Impact Factor: 9.423
2015 SCImago Journal Rankings: 6.883
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorBjörndahl, Men_US
dc.contributor.authorCao, Ren_US
dc.contributor.authorNissen, LJen_US
dc.contributor.authorClasper, Sen_US
dc.contributor.authorJohnson, LAen_US
dc.contributor.authorXue, Yen_US
dc.contributor.authorZhou, Zen_US
dc.contributor.authorJackson, Den_US
dc.contributor.authorHansen, AJen_US
dc.contributor.authorCao, Yen_US
dc.date.accessioned2012-05-29T06:04:22Z-
dc.date.available2012-05-29T06:04:22Z-
dc.date.issued2005en_US
dc.identifier.citationProceedings Of The National Academy Of Sciences Of The United States Of America, 2005, v. 102 n. 43, p. 15593-15598en_US
dc.identifier.issn0027-8424en_US
dc.identifier.urihttp://hdl.handle.net/10722/147526-
dc.description.abstractLymphangiogenesis is an important process that contributes to the spread of cancer. Here we show that insulin-like growth factors 1 (IGF-1) and 2 (IGF-2) induce lymphangiogenesis in vivo. In a mouse cornea assay, IGF-1 and IGF-2 induce lymphangiogenesis as detected with LYVE-1, a specific marker for lymphatic endothelium. Interestingly, IGF-1-induced lymphangiogenesis could not be blocked by a soluble vascular endothelial growth factor receptor 3, suggesting that the vascular endothelial growth factor receptor 3-signaling pathway is not required for IGF-induced lymphangiogenesis. In vitro, IGF-1 and IGF-2 significantly stimulated proliferation and migration of primary lymphatic endothelial cells. IGF-1 and IGF-2 induced phosphorylation of intracellular signaling components, such as Akt, Src, and extracellular signal-regulated kinase in lymphatic endothelial cells, Immunohistochemistry, RT-PCR, and Affymetrix GeneChip microarray analysis showed that the receptors for IGFs are present in lymphatic endothelium. Together, our findings suggest that IGFs might act as direct lymphangiogenic factors, although any indirect roles in the induction of lymphangiogenesis cannot be excluded. Because members of the IGF ligand and receptor families are widely expressed in various types of solid tumors, our findings suggest that these factors are likely to contribute to lymphatic metastasis. © 2005 by The National Academy of Sciences of the USA.en_US
dc.languageengen_US
dc.publisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.orgen_US
dc.relation.ispartofProceedings of the National Academy of Sciences of the United States of Americaen_US
dc.subject.meshAnimalsen_US
dc.subject.meshEndothelium, Lymphatic - Drug Effects - Physiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshInsulin-Like Growth Factor I - Pharmacologyen_US
dc.subject.meshInsulin-Like Growth Factor Ii - Pharmacologyen_US
dc.subject.meshLymphangiogenesis - Drug Effectsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Inbred C57blen_US
dc.subject.meshReceptor, Igf Type 1 - Analysisen_US
dc.subject.meshReceptor, Igf Type 2 - Analysisen_US
dc.subject.meshVascular Endothelial Growth Factor C - Physiologyen_US
dc.subject.meshVascular Endothelial Growth Factor D - Physiologyen_US
dc.subject.meshVascular Endothelial Growth Factor Receptor-3 - Physiologyen_US
dc.titleInsulin-like growth factors 1 and 2 induce lymphangiogenesis in vivoen_US
dc.typeArticleen_US
dc.identifier.emailZhou, Z:zhongjun@hkucc.hku.hken_US
dc.identifier.authorityZhou, Z=rp00503en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1073/pnas.0507865102en_US
dc.identifier.pmid16230630-
dc.identifier.scopuseid_2-s2.0-27344431724en_US
dc.identifier.hkuros102161-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-27344431724&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume102en_US
dc.identifier.issue43en_US
dc.identifier.spage15593en_US
dc.identifier.epage15598en_US
dc.identifier.isiWOS:000232929400059-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridBjörndahl, M=6506759393en_US
dc.identifier.scopusauthoridCao, R=7103341338en_US
dc.identifier.scopusauthoridNissen, LJ=8949758800en_US
dc.identifier.scopusauthoridClasper, S=6602559408en_US
dc.identifier.scopusauthoridJohnson, LA=8949759000en_US
dc.identifier.scopusauthoridXue, Y=36018002300en_US
dc.identifier.scopusauthoridZhou, Z=8631856300en_US
dc.identifier.scopusauthoridJackson, D=7404288815en_US
dc.identifier.scopusauthoridHansen, AJ=7401928823en_US
dc.identifier.scopusauthoridCao, Y=7404524342en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats