File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Influence of Fcγ RIIA and MBL polymorphisms on severe acute respiratory syndrome

TitleInfluence of Fcγ RIIA and MBL polymorphisms on severe acute respiratory syndrome
Authors
KeywordsFcγriia
Mbl
Polymorphisms
Sars
Issue Date2005
PublisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/TAN
Citation
Tissue Antigens, 2005, v. 66 n. 4, p. 291-296 How to Cite?
AbstractPolymorphisms of human Fc γ-receptor IIA (FcγRIIA) and mannose-binding lectin (MBL) genes have been associated with susceptibility to or severity of some infectious diseases. In order to investigate whether these genetic factors might influence susceptibility to infection with the severe acute respiratory syndrome-associated coronavirus (SARS-Cov) as well as the course and severity of the infection, we evaluated polymorphisms of FcγRIIA and MBL genes in DNA samples from a group of approximately 180 people from Hong Kong who were infected with SARS-Cov. These included 132 patients who had moderate course of SARS infection (home subgroup), 26 patients with a severe course requiring treatment in an intensive care ward (ICU subgroup) and a subgroup of 22 patients who died from SARS (deceased subgroup). A total of 200 normal blood donors from the same region were used as controls. A significant association was found between the FcγRIIA-R/R131 genotype and a severe course of SARS, with higher frequency of homozygosity for FcγRIIA-R/R131 in the ICU subgroup of SARS patients when compared with controls (P = 0.03; odds ratio: 3.2; 95% confidence interval: 1.1-9.1). In comparison with controls, a significant difference in linear trend distribution of FcγRIIA genotypes was seen among the severe SARS patients (ICU and deceased subgroups) without co-morbidity, and the incidence of FcγRIIA-H/H131 was lower in these patients as well. There were no significant differences in MBL genotypes and allele frequencies among SARS patients and controls. The study reveals that in addition to age and co-morbidity, FcγRIIA polymorphism of individuals may also influence outcome after infection with the SARS-Cov. © 2005 Blackwell Publishing Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/147525
ISSN
2015 Impact Factor: 2.046
2015 SCImago Journal Rankings: 0.748
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYuan, FFen_US
dc.contributor.authorTanner, Jen_US
dc.contributor.authorChan, PKSen_US
dc.contributor.authorBiffin, Sen_US
dc.contributor.authorDyer, WBen_US
dc.contributor.authorGeczy, AFen_US
dc.contributor.authorTang, JWen_US
dc.contributor.authorHui, DSCen_US
dc.contributor.authorSung, JJYen_US
dc.contributor.authorSullivan, JSen_US
dc.date.accessioned2012-05-29T06:04:21Z-
dc.date.available2012-05-29T06:04:21Z-
dc.date.issued2005en_US
dc.identifier.citationTissue Antigens, 2005, v. 66 n. 4, p. 291-296en_US
dc.identifier.issn0001-2815en_US
dc.identifier.urihttp://hdl.handle.net/10722/147525-
dc.description.abstractPolymorphisms of human Fc γ-receptor IIA (FcγRIIA) and mannose-binding lectin (MBL) genes have been associated with susceptibility to or severity of some infectious diseases. In order to investigate whether these genetic factors might influence susceptibility to infection with the severe acute respiratory syndrome-associated coronavirus (SARS-Cov) as well as the course and severity of the infection, we evaluated polymorphisms of FcγRIIA and MBL genes in DNA samples from a group of approximately 180 people from Hong Kong who were infected with SARS-Cov. These included 132 patients who had moderate course of SARS infection (home subgroup), 26 patients with a severe course requiring treatment in an intensive care ward (ICU subgroup) and a subgroup of 22 patients who died from SARS (deceased subgroup). A total of 200 normal blood donors from the same region were used as controls. A significant association was found between the FcγRIIA-R/R131 genotype and a severe course of SARS, with higher frequency of homozygosity for FcγRIIA-R/R131 in the ICU subgroup of SARS patients when compared with controls (P = 0.03; odds ratio: 3.2; 95% confidence interval: 1.1-9.1). In comparison with controls, a significant difference in linear trend distribution of FcγRIIA genotypes was seen among the severe SARS patients (ICU and deceased subgroups) without co-morbidity, and the incidence of FcγRIIA-H/H131 was lower in these patients as well. There were no significant differences in MBL genotypes and allele frequencies among SARS patients and controls. The study reveals that in addition to age and co-morbidity, FcγRIIA polymorphism of individuals may also influence outcome after infection with the SARS-Cov. © 2005 Blackwell Publishing Ltd.en_US
dc.languageengen_US
dc.publisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/TANen_US
dc.relation.ispartofTissue Antigensen_US
dc.subjectFcγriiaen_US
dc.subjectMblen_US
dc.subjectPolymorphismsen_US
dc.subjectSarsen_US
dc.titleInfluence of Fcγ RIIA and MBL polymorphisms on severe acute respiratory syndromeen_US
dc.typeArticleen_US
dc.identifier.emailTanner, J:jatanner@hku.hken_US
dc.identifier.authorityTanner, J=rp00495en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1399-0039.2005.00476.xen_US
dc.identifier.scopuseid_2-s2.0-26044438261en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-26044438261&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume66en_US
dc.identifier.issue4en_US
dc.identifier.spage291en_US
dc.identifier.epage296en_US
dc.identifier.isiWOS:000232050800005-
dc.publisher.placeDenmarken_US
dc.identifier.scopusauthoridYuan, FF=34877940600en_US
dc.identifier.scopusauthoridTanner, J=35513993000en_US
dc.identifier.scopusauthoridChan, PKS=7403497792en_US
dc.identifier.scopusauthoridBiffin, S=8875945100en_US
dc.identifier.scopusauthoridDyer, WB=7005158623en_US
dc.identifier.scopusauthoridGeczy, AF=7005782375en_US
dc.identifier.scopusauthoridTang, JW=10341387300en_US
dc.identifier.scopusauthoridHui, DSC=7101862411en_US
dc.identifier.scopusauthoridSung, JJY=24473715000en_US
dc.identifier.scopusauthoridSullivan, JS=7403984329en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats