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Article: Vertebroplasty by use of a strontium-containing bioactive bone cement

TitleVertebroplasty by use of a strontium-containing bioactive bone cement
Authors
KeywordsBioactive bone cement
Kyphoplasty
Osseointegration
Osteoporotic spine fracture
Strontium
Vertebroplasty
Issue Date2005
PublisherLippincott, Williams & Wilkins. The Journal's web site is located at http://www.spinejournal.com
Citation
Spine, 2005, v. 30 n. 17 SUPPL., p. S84-S91 How to Cite?
AbstractStudy Design. A review of the laboratory and clinical data for a new strontium-containing hydroxyapatite bioactive bone cement. Objectives. To compare the properties of the strontium-containing bioactive bone cement with those of polymethyl methacrylate (PMMA) and hydroxyapatite (HA) bone cements. Summary of Background Data. Vertebroplasty and kyphoplasty using conventional PMMA bone cements have been effectively used to treat osteoporotic spine fractures with good short- and medium-term results. However, PMMA has some undesirable properties, including its high setting temperature, lack of osseointegration, and large stiffness mismatch with osteoporotic bone. These properties are responsible for some postoperative complications. Methods. Strontium-containing hydroxyapatite (Sr-HA) bioactive bone cement consists of a filler blend of strontium-containing hydroxyapatite, fumed silica and benzoyl peroxide; and a resin blend of bisphenol A diglycidylether methacrylate, triethylene glycol dimethacrylate, poly(ethylene glycol) methacrylate, and N, N-dimethyl-p-toluidine. Its properties, including mechanical strength, setting temperature, biocompatibility, and osseoinduction, were compared with other cements in vitro and in vivo. Early clinical results are presented. Results. The Sr-HA cement has a setting time of 15 to 18 minutes, a maximum setting temperature of 58° C, a compressive strength of 40.9 MPa, bending strength of 31.3 MPa, and a bending modulus of 1,408 MPa. The bending strength and modulus are closer to human cancellous bone. Sr-HA cement promotes osteoblast attachment and mineralization in vitro and bone growth and osseointegration in vivo. In a pilot study, 23 cases of osteoporotic fractures treated with this cement with a mean follow-up of 18 months suggest that it is as effective as PMMA in relieving pain. Discussions. Oral strontium has been shown to induce new bone formation and is effective in reducing fracture risk in osteoporosis. Our data suggest that strontium delivered locally has the same effect; thus, the combination of strontium with HA in a cement with a low setting temperature, adequate stiffness, and low viscosity makes this a good bioactive cement for vertebroplasty and kyphoplasty. ©2005, Lippincott Williams & Wilkins, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/147521
ISSN
2015 Impact Factor: 2.439
2015 SCImago Journal Rankings: 1.459
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, KMCen_HK
dc.contributor.authorLu, WWen_HK
dc.contributor.authorLuk, KDKen_HK
dc.contributor.authorWong, CTen_HK
dc.contributor.authorChan, Den_HK
dc.contributor.authorShen, JXen_HK
dc.contributor.authorQiu, GXen_HK
dc.contributor.authorZheng, ZMen_HK
dc.contributor.authorLi, CHen_HK
dc.contributor.authorLiu, SLen_HK
dc.contributor.authorChan, WKen_HK
dc.contributor.authorLeong, JCYen_HK
dc.date.accessioned2012-05-29T06:04:20Z-
dc.date.available2012-05-29T06:04:20Z-
dc.date.issued2005en_HK
dc.identifier.citationSpine, 2005, v. 30 n. 17 SUPPL., p. S84-S91en_HK
dc.identifier.issn0362-2436en_HK
dc.identifier.urihttp://hdl.handle.net/10722/147521-
dc.description.abstractStudy Design. A review of the laboratory and clinical data for a new strontium-containing hydroxyapatite bioactive bone cement. Objectives. To compare the properties of the strontium-containing bioactive bone cement with those of polymethyl methacrylate (PMMA) and hydroxyapatite (HA) bone cements. Summary of Background Data. Vertebroplasty and kyphoplasty using conventional PMMA bone cements have been effectively used to treat osteoporotic spine fractures with good short- and medium-term results. However, PMMA has some undesirable properties, including its high setting temperature, lack of osseointegration, and large stiffness mismatch with osteoporotic bone. These properties are responsible for some postoperative complications. Methods. Strontium-containing hydroxyapatite (Sr-HA) bioactive bone cement consists of a filler blend of strontium-containing hydroxyapatite, fumed silica and benzoyl peroxide; and a resin blend of bisphenol A diglycidylether methacrylate, triethylene glycol dimethacrylate, poly(ethylene glycol) methacrylate, and N, N-dimethyl-p-toluidine. Its properties, including mechanical strength, setting temperature, biocompatibility, and osseoinduction, were compared with other cements in vitro and in vivo. Early clinical results are presented. Results. The Sr-HA cement has a setting time of 15 to 18 minutes, a maximum setting temperature of 58° C, a compressive strength of 40.9 MPa, bending strength of 31.3 MPa, and a bending modulus of 1,408 MPa. The bending strength and modulus are closer to human cancellous bone. Sr-HA cement promotes osteoblast attachment and mineralization in vitro and bone growth and osseointegration in vivo. In a pilot study, 23 cases of osteoporotic fractures treated with this cement with a mean follow-up of 18 months suggest that it is as effective as PMMA in relieving pain. Discussions. Oral strontium has been shown to induce new bone formation and is effective in reducing fracture risk in osteoporosis. Our data suggest that strontium delivered locally has the same effect; thus, the combination of strontium with HA in a cement with a low setting temperature, adequate stiffness, and low viscosity makes this a good bioactive cement for vertebroplasty and kyphoplasty. ©2005, Lippincott Williams & Wilkins, Inc.en_HK
dc.languageengen_US
dc.publisherLippincott, Williams & Wilkins. The Journal's web site is located at http://www.spinejournal.comen_HK
dc.relation.ispartofSpineen_HK
dc.rightsSpine. Copyright © Lippincott Williams & Wilkins.-
dc.subjectBioactive bone cementen_HK
dc.subjectKyphoplastyen_HK
dc.subjectOsseointegrationen_HK
dc.subjectOsteoporotic spine fractureen_HK
dc.subjectStrontiumen_HK
dc.subjectVertebroplastyen_HK
dc.subject.meshAnimalsen_US
dc.subject.meshBiocompatible Materialsen_US
dc.subject.meshBiomechanicsen_US
dc.subject.meshBone Cements - Chemical Synthesis - Therapeutic Useen_US
dc.subject.meshCell Adhesion - Drug Effectsen_US
dc.subject.meshCell Proliferation - Drug Effectsen_US
dc.subject.meshCells, Cultureden_US
dc.subject.meshDurapatite - Therapeutic Useen_US
dc.subject.meshFractures, Spontaneous - Etiology - Therapyen_US
dc.subject.meshHumansen_US
dc.subject.meshMaterials Testingen_US
dc.subject.meshOsseointegration - Drug Effectsen_US
dc.subject.meshOsteoblasts - Drug Effects - Metabolism - Ultrastructureen_US
dc.subject.meshOsteoporosis - Complicationsen_US
dc.subject.meshPilot Projectsen_US
dc.subject.meshRabbitsen_US
dc.subject.meshSpinal Fractures - Therapyen_US
dc.subject.meshStrontium - Therapeutic Useen_US
dc.titleVertebroplasty by use of a strontium-containing bioactive bone cementen_HK
dc.typeArticleen_HK
dc.identifier.emailCheung, KMC:cheungmc@hku.hken_HK
dc.identifier.emailLu, WW:wwlu@hku.hken_HK
dc.identifier.emailLuk, KDK:hcm21000@hku.hken_HK
dc.identifier.emailChan, D:chand@hkucc.hku.hken_HK
dc.identifier.emailChan, WK:waichan@hku.hken_HK
dc.identifier.authorityCheung, KMC=rp00387en_HK
dc.identifier.authorityLu, WW=rp00411en_HK
dc.identifier.authorityLuk, KDK=rp00333en_HK
dc.identifier.authorityChan, D=rp00540en_HK
dc.identifier.authorityChan, WK=rp00667en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1097/01.brs.0000175183.57733.e5-
dc.identifier.pmid16138071-
dc.identifier.scopuseid_2-s2.0-24744454821en_HK
dc.identifier.hkuros111723-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-24744454821&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume30en_HK
dc.identifier.issue17 SUPPL.en_HK
dc.identifier.spageS84en_HK
dc.identifier.epageS91en_HK
dc.identifier.isiWOS:000231770500014-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridCheung, KMC=7402406754en_HK
dc.identifier.scopusauthoridLu, WW=7404215221en_HK
dc.identifier.scopusauthoridLuk, KDK=7201921573en_HK
dc.identifier.scopusauthoridWong, CT=7404954512en_HK
dc.identifier.scopusauthoridChan, D=7402216545en_HK
dc.identifier.scopusauthoridShen, JX=7404929807en_HK
dc.identifier.scopusauthoridQiu, GX=7103291762en_HK
dc.identifier.scopusauthoridZheng, ZM=7403007434en_HK
dc.identifier.scopusauthoridLi, CH=7501676450en_HK
dc.identifier.scopusauthoridLiu, SL=8701476800en_HK
dc.identifier.scopusauthoridChan, WK=13310083000en_HK
dc.identifier.scopusauthoridLeong, JCY=35563743000en_HK

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