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Article: Fos expression in otolith-related brainstem neurons of postnatal rats following off-vertical axis rotation

TitleFos expression in otolith-related brainstem neurons of postnatal rats following off-vertical axis rotation
Authors
KeywordsBrainstem nuclei
C-fos
Development
Immunohistochemistry
Utricle
Vestibular nuclei
Issue Date2004
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/31248
Citation
Journal Of Comparative Neurology, 2004, v. 470 n. 3, p. 282-296 How to Cite?
AbstractTo determine the critical time of responsiveness of developing otolith organ-related brainstem neurons and their distribution, Fos protein expression in response to off-vertical axis rotations (OVAR) was mapped in conscious Sprague Dawley rats from P5 to adulthood. OVAR was used to activate sequentially all utricular hair cells per 360° revolution. We detected the coding of horizontal head positions in otolith organ-related neurons within the vestibular nucleus as early as P7. In the vestibular nuclear complex and its subgroups, the density of Fos-immunoreactive (Fos-ir) neurons increased steadily with age and reached the adult level by P21. In both labyrinthectomized rats subjected to OVAR and normal rats kept stationary, labeled neurons were found sporadically in the aforementioned brain regions in each age group, confirming that Fos labeling observed in neurons of normal experimental rats subjected to OVAR was due to otolith organ stimulation. Whereas OVAR-induced Fos-ir neurons were also first observed in vestibular-related brain areas, such as the prepositus hypoglossal nucleus, giganto-cellular reticular nucleus, and locus coeruleus, of normal experimental rats at P7, those in the inferior olive were observed only from P14 onward. This indicates the unique maturation time of inferior olivary neurons in gravity-related spatial coding. In general, age-dependent increase in OVAR-induced Fos-ir neurons was observed in brain areas that received otolith inputs. The locus coeruleus was exceptional in that prominent OVAR-induced Fos-ir neuronal number did not change with maturation, and this was well above the low but significant number of Fos-ir neurons in control preparations. Taken together, our results suggest that neuronal subpopulations within the developing network of the horizontal otolith system provide an anatomical basis for the postnatal development of otolith organ-related sensorimotor functions. © 2004 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/147494
ISSN
2015 Impact Factor: 3.331
2015 SCImago Journal Rankings: 2.345
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLai, CHen_HK
dc.contributor.authorTse, YCen_HK
dc.contributor.authorShum, DKYen_HK
dc.contributor.authorYung, KKLen_HK
dc.contributor.authorChan, YSen_HK
dc.date.accessioned2012-05-29T06:04:07Z-
dc.date.available2012-05-29T06:04:07Z-
dc.date.issued2004en_HK
dc.identifier.citationJournal Of Comparative Neurology, 2004, v. 470 n. 3, p. 282-296en_HK
dc.identifier.issn0021-9967en_HK
dc.identifier.urihttp://hdl.handle.net/10722/147494-
dc.description.abstractTo determine the critical time of responsiveness of developing otolith organ-related brainstem neurons and their distribution, Fos protein expression in response to off-vertical axis rotations (OVAR) was mapped in conscious Sprague Dawley rats from P5 to adulthood. OVAR was used to activate sequentially all utricular hair cells per 360° revolution. We detected the coding of horizontal head positions in otolith organ-related neurons within the vestibular nucleus as early as P7. In the vestibular nuclear complex and its subgroups, the density of Fos-immunoreactive (Fos-ir) neurons increased steadily with age and reached the adult level by P21. In both labyrinthectomized rats subjected to OVAR and normal rats kept stationary, labeled neurons were found sporadically in the aforementioned brain regions in each age group, confirming that Fos labeling observed in neurons of normal experimental rats subjected to OVAR was due to otolith organ stimulation. Whereas OVAR-induced Fos-ir neurons were also first observed in vestibular-related brain areas, such as the prepositus hypoglossal nucleus, giganto-cellular reticular nucleus, and locus coeruleus, of normal experimental rats at P7, those in the inferior olive were observed only from P14 onward. This indicates the unique maturation time of inferior olivary neurons in gravity-related spatial coding. In general, age-dependent increase in OVAR-induced Fos-ir neurons was observed in brain areas that received otolith inputs. The locus coeruleus was exceptional in that prominent OVAR-induced Fos-ir neuronal number did not change with maturation, and this was well above the low but significant number of Fos-ir neurons in control preparations. Taken together, our results suggest that neuronal subpopulations within the developing network of the horizontal otolith system provide an anatomical basis for the postnatal development of otolith organ-related sensorimotor functions. © 2004 Wiley-Liss, Inc.en_HK
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/31248en_HK
dc.relation.ispartofJournal of Comparative Neurologyen_HK
dc.subjectBrainstem nucleien_HK
dc.subjectC-fosen_HK
dc.subjectDevelopmenten_HK
dc.subjectImmunohistochemistryen_HK
dc.subjectUtricleen_HK
dc.subjectVestibular nucleien_HK
dc.subject.meshAge Factorsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnimals, Newbornen_US
dc.subject.meshBrain Stem - Cytology - Growth & Development - Metabolismen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene Expression Regulation, Developmentalen_US
dc.subject.meshMaleen_US
dc.subject.meshNeurons - Metabolismen_US
dc.subject.meshOtolithic Membrane - Cytology - Growth & Development - Metabolismen_US
dc.subject.meshProto-Oncogene Proteins C-Fos - Biosynthesis - Geneticsen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshRotationen_US
dc.titleFos expression in otolith-related brainstem neurons of postnatal rats following off-vertical axis rotationen_HK
dc.typeArticleen_HK
dc.identifier.emailLai, CH: chlaib@hku.hken_HK
dc.identifier.emailShum, DKY: shumdkhk@hkucc.hku.hken_HK
dc.identifier.emailChan, YS: yschan@hkucc.hku.hken_HK
dc.identifier.authorityLai, CH=rp00396en_HK
dc.identifier.authorityShum, DKY=rp00321en_HK
dc.identifier.authorityChan, YS=rp00318en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/cne.11048en_HK
dc.identifier.pmid14755517-
dc.identifier.scopuseid_2-s2.0-0742270444en_HK
dc.identifier.hkuros88201-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0742270444&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume470en_HK
dc.identifier.issue3en_HK
dc.identifier.spage282en_HK
dc.identifier.epage296en_HK
dc.identifier.isiWOS:000188782000005-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLai, CH=7403086597en_HK
dc.identifier.scopusauthoridTse, YC=7005116869en_HK
dc.identifier.scopusauthoridShum, DKY=7004824447en_HK
dc.identifier.scopusauthoridYung, KKL=13605496000en_HK
dc.identifier.scopusauthoridChan, YS=7403676627en_HK

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