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Article: A novel gene IC53 stimulates ECV304 cell proliferation and is upregulated in failing heart

TitleA novel gene IC53 stimulates ECV304 cell proliferation and is upregulated in failing heart
Authors
Issue Date2002
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/description
Citation
Biochemical And Biophysical Research Communications, 2002, v. 294 n. 1, p. 161-166 How to Cite?
AbstractC53, cloned from rat brain cDNA library, can bind to p35, the precursor of activator of Cdk5. A novel gene with 84% homolog To C53, named IC53, was cloned from our 5300 EST database of human aorta cDNA library (GenBank Accession No. AF110322). Computational analysis showed that IC53 cDNA is 2538 bp long, encoding 419 amino acids, mapped to chromosome 17q21.31 with 12 exons, ubiquitously expressed in 12 tested normal tissues and 8 tumor cell lines from MTN membranes and vascular endothelial Cells by Northern blot and in situ hybridization, and upregulated in the rat models of subacute heart failure and chronic ischemic Heart failure by left coronary ligation. Stable transfection of IC53 stimulates ECV304 cell proliferation by 2.1-fold compared to cells With empty vector (P < 0:05). The results support that IC53 is a novel gene, mainly expressed in vascular endothelial cells and Mediates cell proliferation. © 2002 Elsevier Science (USA). All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/147472
ISSN
2015 Impact Factor: 2.371
2015 SCImago Journal Rankings: 1.152
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChen, Jen_US
dc.contributor.authorLiu, Ben_US
dc.contributor.authorLiu, Yen_US
dc.contributor.authorHan, Yen_US
dc.contributor.authorYu, Hen_US
dc.contributor.authorZhang, Yen_US
dc.contributor.authorLu, Len_US
dc.contributor.authorZhen, Yen_US
dc.contributor.authorHui, Ren_US
dc.date.accessioned2012-05-29T06:03:57Z-
dc.date.available2012-05-29T06:03:57Z-
dc.date.issued2002en_US
dc.identifier.citationBiochemical And Biophysical Research Communications, 2002, v. 294 n. 1, p. 161-166en_US
dc.identifier.issn0006-291Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/147472-
dc.description.abstractC53, cloned from rat brain cDNA library, can bind to p35, the precursor of activator of Cdk5. A novel gene with 84% homolog To C53, named IC53, was cloned from our 5300 EST database of human aorta cDNA library (GenBank Accession No. AF110322). Computational analysis showed that IC53 cDNA is 2538 bp long, encoding 419 amino acids, mapped to chromosome 17q21.31 with 12 exons, ubiquitously expressed in 12 tested normal tissues and 8 tumor cell lines from MTN membranes and vascular endothelial Cells by Northern blot and in situ hybridization, and upregulated in the rat models of subacute heart failure and chronic ischemic Heart failure by left coronary ligation. Stable transfection of IC53 stimulates ECV304 cell proliferation by 2.1-fold compared to cells With empty vector (P < 0:05). The results support that IC53 is a novel gene, mainly expressed in vascular endothelial cells and Mediates cell proliferation. © 2002 Elsevier Science (USA). All rights reserved.en_US
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/descriptionen_US
dc.relation.ispartofBiochemical and Biophysical Research Communicationsen_US
dc.subject.meshAmino Acid Sequenceen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAorta - Chemistryen_US
dc.subject.meshBase Sequenceen_US
dc.subject.meshCarrier Proteins - Genetics - Physiologyen_US
dc.subject.meshCell Division - Geneticsen_US
dc.subject.meshChromosomes, Human, Pair 17en_US
dc.subject.meshCloning, Molecularen_US
dc.subject.meshEndothelium, Vascular - Cytology - Growth & Developmenten_US
dc.subject.meshHumansen_US
dc.subject.meshIn Situ Hybridizationen_US
dc.subject.meshIntracellular Signaling Peptides And Proteinsen_US
dc.subject.meshMaleen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshMuscle Proteins - Genetics - Physiologyen_US
dc.subject.meshMyocardial Ischemia - Pathologyen_US
dc.subject.meshNerve Tissue Proteins - Genetics - Physiologyen_US
dc.subject.meshOpen Reading Framesen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshTumor Cells, Cultureden_US
dc.subject.meshUp-Regulationen_US
dc.titleA novel gene IC53 stimulates ECV304 cell proliferation and is upregulated in failing hearten_US
dc.typeArticleen_US
dc.identifier.emailLiu, B:ppliew@hkusua.hku.hken_US
dc.identifier.authorityLiu, B=rp01485en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0006-291X(02)00446-1en_US
dc.identifier.pmid12054757-
dc.identifier.scopuseid_2-s2.0-0036290051en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036290051&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume294en_US
dc.identifier.issue1en_US
dc.identifier.spage161en_US
dc.identifier.epage166en_US
dc.identifier.isiWOS:000176234500027-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridChen, J=23033557300en_US
dc.identifier.scopusauthoridLiu, B=7408693394en_US
dc.identifier.scopusauthoridLiu, Y=14627533300en_US
dc.identifier.scopusauthoridHan, Y=7404096105en_US
dc.identifier.scopusauthoridYu, H=23981835300en_US
dc.identifier.scopusauthoridZhang, Y=8320316000en_US
dc.identifier.scopusauthoridLu, L=7403963778en_US
dc.identifier.scopusauthoridZhen, Y=8608594300en_US
dc.identifier.scopusauthoridHui, R=7006029377en_US

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