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Article: Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I

TitleImpaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I
Authors
Issue Date2000
PublisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.org
Citation
Proceedings Of The National Academy Of Sciences Of The United States Of America, 2000, v. 97 n. 8, p. 4052-4057 How to Cite?
AbstractMembrane-type matrix metalloproteinase I (MT1-MMP)-deficient mice were found to have severe defects in skeletal development and angiogenesis. The craniofacial, axial, and appendicular skeletons were severely affected, leading to a short and domed skull, marked deceleration of postnatal growth, and death by 3 wk of age. Shortening of bones is a consequence of decreased chondrocyte proliferation in the proliferative zone of the growth plates. Defective vascular invasion of cartilage leads to enlargement of hypertrophic zones of growth plates and delayed formation of secondary ossification centers in long bones. In an in vivo corneal angiogenesis assay, null mice did not have angiogenic response to implanted FGF-2, suggesting that the defect in angiogenesis is not restricted to cartilage alone. In tissues from null mice, activation of latent matrix metalloproteinase 2 was deficient, suggesting that MT1-MMP is essential for its activation in vivo.
Persistent Identifierhttp://hdl.handle.net/10722/147453
ISSN
2015 Impact Factor: 9.423
2015 SCImago Journal Rankings: 6.883
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhou, Zen_US
dc.contributor.authorApte, SSen_US
dc.contributor.authorSoininen, Ren_US
dc.contributor.authorCao, Ren_US
dc.contributor.authorBaaklini, GYen_US
dc.contributor.authorRauser, RWen_US
dc.contributor.authorWang, Jen_US
dc.contributor.authorCao, Yen_US
dc.contributor.authorTryggvason, Ken_US
dc.date.accessioned2012-05-29T06:03:49Z-
dc.date.available2012-05-29T06:03:49Z-
dc.date.issued2000en_US
dc.identifier.citationProceedings Of The National Academy Of Sciences Of The United States Of America, 2000, v. 97 n. 8, p. 4052-4057en_US
dc.identifier.issn0027-8424en_US
dc.identifier.urihttp://hdl.handle.net/10722/147453-
dc.description.abstractMembrane-type matrix metalloproteinase I (MT1-MMP)-deficient mice were found to have severe defects in skeletal development and angiogenesis. The craniofacial, axial, and appendicular skeletons were severely affected, leading to a short and domed skull, marked deceleration of postnatal growth, and death by 3 wk of age. Shortening of bones is a consequence of decreased chondrocyte proliferation in the proliferative zone of the growth plates. Defective vascular invasion of cartilage leads to enlargement of hypertrophic zones of growth plates and delayed formation of secondary ossification centers in long bones. In an in vivo corneal angiogenesis assay, null mice did not have angiogenic response to implanted FGF-2, suggesting that the defect in angiogenesis is not restricted to cartilage alone. In tissues from null mice, activation of latent matrix metalloproteinase 2 was deficient, suggesting that MT1-MMP is essential for its activation in vivo.en_US
dc.languageengen_US
dc.publisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.orgen_US
dc.relation.ispartofProceedings of the National Academy of Sciences of the United States of Americaen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBone Development - Geneticsen_US
dc.subject.meshChondrogenesis - Geneticsen_US
dc.subject.meshCornea - Blood Supplyen_US
dc.subject.meshEnzyme Activationen_US
dc.subject.meshEnzyme Precursors - Metabolismen_US
dc.subject.meshGene Targetingen_US
dc.subject.meshGrowth Plate - Growth & Developmenten_US
dc.subject.meshHeterozygoteen_US
dc.subject.meshHomozygoteen_US
dc.subject.meshMatrix Metalloproteinase 1 - Genetics - Metabolismen_US
dc.subject.meshMatrix Metalloproteinase 2 - Metabolismen_US
dc.subject.meshMatrix Metalloproteinase 9 - Metabolismen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Transgenicen_US
dc.subject.meshNeovascularization, Physiologicen_US
dc.titleImpaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase Ien_US
dc.typeArticleen_US
dc.identifier.emailZhou, Z:zhongjun@hkucc.hku.hken_US
dc.identifier.authorityZhou, Z=rp00503en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1073/pnas.060037197en_US
dc.identifier.pmid10737763-
dc.identifier.scopuseid_2-s2.0-0034635966en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034635966&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume97en_US
dc.identifier.issue8en_US
dc.identifier.spage4052en_US
dc.identifier.epage4057en_US
dc.identifier.isiWOS:000086461100050-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridZhou, Z=8631856300en_US
dc.identifier.scopusauthoridApte, SS=7101907193en_US
dc.identifier.scopusauthoridSoininen, R=7003955362en_US
dc.identifier.scopusauthoridCao, R=7103341338en_US
dc.identifier.scopusauthoridBaaklini, GY=7004721779en_US
dc.identifier.scopusauthoridRauser, RW=6506187085en_US
dc.identifier.scopusauthoridWang, J=8631854400en_US
dc.identifier.scopusauthoridCao, Y=7404524342en_US
dc.identifier.scopusauthoridTryggvason, K=7102025185en_US

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