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Article: Molecular genetic dissection of mouse unconventional myosin-VA: Tail region mutations

TitleMolecular genetic dissection of mouse unconventional myosin-VA: Tail region mutations
Authors
Issue Date1998
PublisherGenetics Society of America. The Journal's web site is located at http://www.genetics.org/contents-by-date.0.shtml
Citation
Genetics, 1998, v. 148 n. 4, p. 1963-1972 How to Cite?
AbstractWe used an RT-PCR-based sequencing approach to identify the mutations responsible for 17 viable dilute alleles, a mouse-coat-color locus encoding unconventional myosin-VA. Ten of the mutations mapped to the MyoVA tail and are reported here. These mutations represent the first extensive collection of tail mutations reported for any unconventional mammalian myosin. They identify sequences important for tail function and identify domains potentially involved in cargo binding and/or proper folding of the MyoVA tail. Our results also provide support for the notion that different myosin tail isoforms produced by alternative splicing encode important cell-type- specific functions.
Persistent Identifierhttp://hdl.handle.net/10722/147432
ISSN
2015 Impact Factor: 4.644
2015 SCImago Journal Rankings: 4.270
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHuang, JDen_US
dc.contributor.authorMermall, Ven_US
dc.contributor.authorStrobel, MCen_US
dc.contributor.authorRussell, LBen_US
dc.contributor.authorMooseker, MSen_US
dc.contributor.authorCopeland, NGen_US
dc.contributor.authorJenkins, NAen_US
dc.date.accessioned2012-05-29T06:03:41Z-
dc.date.available2012-05-29T06:03:41Z-
dc.date.issued1998en_US
dc.identifier.citationGenetics, 1998, v. 148 n. 4, p. 1963-1972en_US
dc.identifier.issn0016-6731en_US
dc.identifier.urihttp://hdl.handle.net/10722/147432-
dc.description.abstractWe used an RT-PCR-based sequencing approach to identify the mutations responsible for 17 viable dilute alleles, a mouse-coat-color locus encoding unconventional myosin-VA. Ten of the mutations mapped to the MyoVA tail and are reported here. These mutations represent the first extensive collection of tail mutations reported for any unconventional mammalian myosin. They identify sequences important for tail function and identify domains potentially involved in cargo binding and/or proper folding of the MyoVA tail. Our results also provide support for the notion that different myosin tail isoforms produced by alternative splicing encode important cell-type- specific functions.en_US
dc.languageengen_US
dc.publisherGenetics Society of America. The Journal's web site is located at http://www.genetics.org/contents-by-date.0.shtmlen_US
dc.relation.ispartofGeneticsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBase Sequenceen_US
dc.subject.meshDnaen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene Expressionen_US
dc.subject.meshIntermediate Filament Proteins - Biosynthesis - Geneticsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Inbred C3hen_US
dc.subject.meshMice, Inbred C57blen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshMutagenesisen_US
dc.subject.meshMyosin Heavy Chainsen_US
dc.subject.meshMyosin Type Ven_US
dc.subject.meshRna, Messengeren_US
dc.subject.meshSequence Deletionen_US
dc.titleMolecular genetic dissection of mouse unconventional myosin-VA: Tail region mutationsen_US
dc.typeArticleen_US
dc.identifier.emailHuang, JD:jdhuang@hkucc.hku.hken_US
dc.identifier.authorityHuang, JD=rp00451en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid9560409-
dc.identifier.scopuseid_2-s2.0-0031952875en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031952875&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume148en_US
dc.identifier.issue4en_US
dc.identifier.spage1963en_US
dc.identifier.epage1972en_US
dc.identifier.isiWOS:000073187000054-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridHuang, JD=8108660600en_US
dc.identifier.scopusauthoridMermall, V=6602545621en_US
dc.identifier.scopusauthoridStrobel, MC=7103301364en_US
dc.identifier.scopusauthoridRussell, LB=7202252250en_US
dc.identifier.scopusauthoridMooseker, MS=7006520381en_US
dc.identifier.scopusauthoridCopeland, NG=35374759300en_US
dc.identifier.scopusauthoridJenkins, NA=35379887700en_US

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