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Article: Up-regulation of human secreted frizzled homolog in apoptosis and its down-regulation in breast tumors

TitleUp-regulation of human secreted frizzled homolog in apoptosis and its down-regulation in breast tumors
Authors
Issue Date1998
PublisherJohn Wiley & Sons, Inc.. The Journal's web site is located at http://www3.interscience.wiley.com/journal/29331/home
Citation
International Journal Of Cancer, 1998, v. 78 n. 1, p. 95-99 How to Cite?
AbstractIn the screening of apoptosis-related genes, an elevated 4.5-kb transcript representing the full-length cDNA of human secreted frizzled- related protein (hsFRP) was cloned. To investigate its possible role in the regulation of cell proliferation, gene expression of hsFRP was examined in human immortalized breast epithelial cell line HBL- 100 during growth arrest and apoptosis. Serum deprivation caused G1 arrest and induction of hsFRP. When serum was re-introduced into the cell culture, the expression of hsFRP declined. Adriamycin treatment induced accumulation of hsFRP mRNA and decrease of β-catenin. This indicates that the regulation of hsFRP may be involved in the cell-cycle/apoptosis mechanism and possibly in the wnt signaling pathway. hsFRP transcripts were undetectable in cells derived from malignant breast carcinomas, but detectable in 3 immortalized non-malignant breast epithelial cell lines, indicating the involvement of hsFRP in the breast malignant transformation. When tumor and adjacent normal tissues from the same patients were examined, lower expression was found in 515 of breast tumors, 214 of ovary tumors and 3/5 of kidney tumors. These data suggest the possible involvement of hsFRP in regulation of cell proliferation and breast tumorigenesis.
Persistent Identifierhttp://hdl.handle.net/10722/147429
ISSN
2015 Impact Factor: 5.531
2015 SCImago Journal Rankings: 2.657
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhou, Zen_US
dc.contributor.authorWang, Jen_US
dc.contributor.authorHan, Xen_US
dc.contributor.authorZhou, Jen_US
dc.contributor.authorLinder, Sen_US
dc.date.accessioned2012-05-29T06:03:40Z-
dc.date.available2012-05-29T06:03:40Z-
dc.date.issued1998en_US
dc.identifier.citationInternational Journal Of Cancer, 1998, v. 78 n. 1, p. 95-99en_US
dc.identifier.issn0020-7136en_US
dc.identifier.urihttp://hdl.handle.net/10722/147429-
dc.description.abstractIn the screening of apoptosis-related genes, an elevated 4.5-kb transcript representing the full-length cDNA of human secreted frizzled- related protein (hsFRP) was cloned. To investigate its possible role in the regulation of cell proliferation, gene expression of hsFRP was examined in human immortalized breast epithelial cell line HBL- 100 during growth arrest and apoptosis. Serum deprivation caused G1 arrest and induction of hsFRP. When serum was re-introduced into the cell culture, the expression of hsFRP declined. Adriamycin treatment induced accumulation of hsFRP mRNA and decrease of β-catenin. This indicates that the regulation of hsFRP may be involved in the cell-cycle/apoptosis mechanism and possibly in the wnt signaling pathway. hsFRP transcripts were undetectable in cells derived from malignant breast carcinomas, but detectable in 3 immortalized non-malignant breast epithelial cell lines, indicating the involvement of hsFRP in the breast malignant transformation. When tumor and adjacent normal tissues from the same patients were examined, lower expression was found in 515 of breast tumors, 214 of ovary tumors and 3/5 of kidney tumors. These data suggest the possible involvement of hsFRP in regulation of cell proliferation and breast tumorigenesis.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc.. The Journal's web site is located at http://www3.interscience.wiley.com/journal/29331/homeen_US
dc.relation.ispartofInternational Journal of Canceren_US
dc.subject.meshApoptosisen_US
dc.subject.meshBreast Neoplasms - Etiology - Metabolismen_US
dc.subject.meshDown-Regulationen_US
dc.subject.meshFemaleen_US
dc.subject.meshFrizzled Receptorsen_US
dc.subject.meshHumansen_US
dc.subject.meshNeoplasm Proteins - Metabolismen_US
dc.subject.meshProteins - Metabolismen_US
dc.subject.meshTumor Cells, Cultureden_US
dc.subject.meshUp-Regulationen_US
dc.titleUp-regulation of human secreted frizzled homolog in apoptosis and its down-regulation in breast tumorsen_US
dc.typeArticleen_US
dc.identifier.emailZhou, Z:zhongjun@hkucc.hku.hken_US
dc.identifier.authorityZhou, Z=rp00503en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/(SICI)1097-0215(19980925)78:1<95::AID-IJC15>3.0.CO;2-4en_US
dc.identifier.pmid9724099-
dc.identifier.scopuseid_2-s2.0-0031870862en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031870862&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume78en_US
dc.identifier.issue1en_US
dc.identifier.spage95en_US
dc.identifier.epage99en_US
dc.identifier.isiWOS:000075543400015-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridZhou, Z=8631856300en_US
dc.identifier.scopusauthoridWang, J=8631854400en_US
dc.identifier.scopusauthoridHan, X=7402401317en_US
dc.identifier.scopusauthoridZhou, J=7405552245en_US
dc.identifier.scopusauthoridLinder, S=7103323193en_US

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