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Article: Changes in glycosaminoglycans during regeneration of post-crush sciatic nerves of adult guinea pigs

TitleChanges in glycosaminoglycans during regeneration of post-crush sciatic nerves of adult guinea pigs
Authors
Issue Date1996
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/34828
Citation
Journal Of Neuroscience Research, 1996, v. 46 n. 4, p. 465-476 How to Cite?
AbstractThe glycosaminoglycans of sciatic nerves recovering from crush-injury were studied in adult guinea pigs and compared with those of non-injured mature neural tissues. The glycosaminoglycans were recovered from the 1,900 g supernatant and pellet of the tissue homogenates and assayed for hexuronate contents and susceptibilities to hyaluronidase, chondroitinase ABC, and nitrous acid. In the normal brain and central nerve tracts, the glycosoaminoglycans were distributed both in the supernatant and pellet fractions; the brain showed a predominance of chondroitin sulphates but the tracts showed a predominance of heparan sulphates. Twice as much glycosaminoglycans were found in normal sciatic nerves, only in the pellet fraction and with heparan sulphate predominant. In the 2 weeks post-crush, progressive increase in hexuronate was observed, due mainly to additional chondroitin sulphate forms in the supernatant; the pellet fraction in the same period was however similar to the untreated controls in relative abundance of glycosaminoglycan classes and hexuronate content. At 4 weeks post-crush, although the total hexuronate returned to the control level, a significant proportion of glycosaminoglycans remained in the supernatant fraction. Evidence is thus provided for the need to modulate the glycosaminoglycan expression pattern in adult neural tissue to allow post- traumatic tissue remodelling and axonal regrowth.
Persistent Identifierhttp://hdl.handle.net/10722/147405
ISSN
2015 Impact Factor: 2.689
2015 SCImago Journal Rankings: 1.261
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorShum, DKYen_US
dc.contributor.authorChau, CHen_US
dc.date.accessioned2012-05-29T06:03:29Z-
dc.date.available2012-05-29T06:03:29Z-
dc.date.issued1996en_US
dc.identifier.citationJournal Of Neuroscience Research, 1996, v. 46 n. 4, p. 465-476en_US
dc.identifier.issn0360-4012en_US
dc.identifier.urihttp://hdl.handle.net/10722/147405-
dc.description.abstractThe glycosaminoglycans of sciatic nerves recovering from crush-injury were studied in adult guinea pigs and compared with those of non-injured mature neural tissues. The glycosaminoglycans were recovered from the 1,900 g supernatant and pellet of the tissue homogenates and assayed for hexuronate contents and susceptibilities to hyaluronidase, chondroitinase ABC, and nitrous acid. In the normal brain and central nerve tracts, the glycosoaminoglycans were distributed both in the supernatant and pellet fractions; the brain showed a predominance of chondroitin sulphates but the tracts showed a predominance of heparan sulphates. Twice as much glycosaminoglycans were found in normal sciatic nerves, only in the pellet fraction and with heparan sulphate predominant. In the 2 weeks post-crush, progressive increase in hexuronate was observed, due mainly to additional chondroitin sulphate forms in the supernatant; the pellet fraction in the same period was however similar to the untreated controls in relative abundance of glycosaminoglycan classes and hexuronate content. At 4 weeks post-crush, although the total hexuronate returned to the control level, a significant proportion of glycosaminoglycans remained in the supernatant fraction. Evidence is thus provided for the need to modulate the glycosaminoglycan expression pattern in adult neural tissue to allow post- traumatic tissue remodelling and axonal regrowth.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/34828en_US
dc.relation.ispartofJournal of Neuroscience Researchen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBrain Chemistryen_US
dc.subject.meshCell Adhesionen_US
dc.subject.meshChondroitin Lyases - Pharmacologyen_US
dc.subject.meshChondroitin Sulfates - Isolation & Purificationen_US
dc.subject.meshDermatan Sulfate - Isolation & Purificationen_US
dc.subject.meshGlycosaminoglycans - Isolation & Purificationen_US
dc.subject.meshGuinea Pigsen_US
dc.subject.meshHeparitin Sulfate - Isolation & Purificationen_US
dc.subject.meshHyaluronic Acid - Isolation & Purificationen_US
dc.subject.meshHyaluronoglucosaminidase - Pharmacologyen_US
dc.subject.meshNerve Crushen_US
dc.subject.meshNerve Regenerationen_US
dc.subject.meshNitrous Acid - Pharmacologyen_US
dc.subject.meshOlfactory Nerve - Chemistryen_US
dc.subject.meshOptic Nerve - Chemistryen_US
dc.subject.meshOrgan Specificityen_US
dc.subject.meshSciatic Nerve - Chemistry - Physiologyen_US
dc.subject.meshSodium Hydroxide - Pharmacologyen_US
dc.titleChanges in glycosaminoglycans during regeneration of post-crush sciatic nerves of adult guinea pigsen_US
dc.typeArticleen_US
dc.identifier.emailShum, DKY:shumdkhk@hkucc.hku.hken_US
dc.identifier.emailChau, CH:mchchau@hkucc.hku.hken_US
dc.identifier.authorityShum, DKY=rp00321en_US
dc.identifier.authorityChau, CH=rp00398en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/(SICI)1097-4547(19961115)46:4<465::AID-JNR8>3.0.CO;2-Een_US
dc.identifier.pmid8950706-
dc.identifier.scopuseid_2-s2.0-0029829669en_US
dc.identifier.hkuros25885-
dc.identifier.hkuros25032-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0029829669&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume46en_US
dc.identifier.issue4en_US
dc.identifier.spage465en_US
dc.identifier.epage476en_US
dc.identifier.isiWOS:A1996VV51900008-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridShum, DKY=7004824447en_US
dc.identifier.scopusauthoridChau, CH=10040110500en_US

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