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Article: The decapentaplegic core promoter region plays an integral role in the spatial control of transcription

TitleThe decapentaplegic core promoter region plays an integral role in the spatial control of transcription
Authors
Issue Date1995
Citation
Molecular And Cellular Biology, 1995, v. 15 n. 7, p. 3960-3968 How to Cite?
AbstractThe Drosophila melanogaster decapentaplegic (dpp) gene encodes a transforming growth factor β-related cell signaling molecule that plays a critical role in dorsal/ventral pattern formation. The dpp expression pattern in the Drosophila embryo is dynamic, consisting of three phases. Phase I, in which dpp is expressed in a broad dorsal domain, depends on elements in the dpp second intron that interact with the Dorsal transcription factor to repress transcription ventrally. In contrast, phases II and III, in which dpp is expressed first in broad longitudinal stripes (phase II) and subsequently in narrow longitudinal stripes (phase III), depend on multiple independent elements in the dpp 5'-flanking region. Several aspects of the normal dpp expression pattern appear to depend on the unique properties of the dpp core promoter. For example, this core promoter (extending from -22 to +6) is able to direct a phase II expression pattern in the absence of additional upstream or downstream regulatory elements. In addition, a ventral-specific enhancer in the dpp 5'-flanking region that binds the Dorsal factor activates the heterologous hsp70 core promoter but not the dpp core promoter. Thus, the dpp core promoter region may contribute to spatially regulated transcription both by interacting directly with spatially restricted activators and by modifying the activity of proteins bound to enhancer elements.
Persistent Identifierhttp://hdl.handle.net/10722/147397
ISSN
2015 Impact Factor: 4.427
2015 SCImago Journal Rankings: 3.806
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSchwyter, DHen_US
dc.contributor.authorHuang, JDen_US
dc.contributor.authorDubnicoff, Ten_US
dc.contributor.authorCourey, AJen_US
dc.date.accessioned2012-05-29T06:03:25Z-
dc.date.available2012-05-29T06:03:25Z-
dc.date.issued1995en_US
dc.identifier.citationMolecular And Cellular Biology, 1995, v. 15 n. 7, p. 3960-3968en_US
dc.identifier.issn0270-7306en_US
dc.identifier.urihttp://hdl.handle.net/10722/147397-
dc.description.abstractThe Drosophila melanogaster decapentaplegic (dpp) gene encodes a transforming growth factor β-related cell signaling molecule that plays a critical role in dorsal/ventral pattern formation. The dpp expression pattern in the Drosophila embryo is dynamic, consisting of three phases. Phase I, in which dpp is expressed in a broad dorsal domain, depends on elements in the dpp second intron that interact with the Dorsal transcription factor to repress transcription ventrally. In contrast, phases II and III, in which dpp is expressed first in broad longitudinal stripes (phase II) and subsequently in narrow longitudinal stripes (phase III), depend on multiple independent elements in the dpp 5'-flanking region. Several aspects of the normal dpp expression pattern appear to depend on the unique properties of the dpp core promoter. For example, this core promoter (extending from -22 to +6) is able to direct a phase II expression pattern in the absence of additional upstream or downstream regulatory elements. In addition, a ventral-specific enhancer in the dpp 5'-flanking region that binds the Dorsal factor activates the heterologous hsp70 core promoter but not the dpp core promoter. Thus, the dpp core promoter region may contribute to spatially regulated transcription both by interacting directly with spatially restricted activators and by modifying the activity of proteins bound to enhancer elements.en_US
dc.languageengen_US
dc.relation.ispartofMolecular and Cellular Biologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBase Sequenceen_US
dc.subject.meshBlastodermen_US
dc.subject.meshDna Mutational Analysisen_US
dc.subject.meshDna-Binding Proteins - Metabolismen_US
dc.subject.meshDrosophila - Embryology - Geneticsen_US
dc.subject.meshDrosophila Proteinsen_US
dc.subject.meshEmbryonic Inductionen_US
dc.subject.meshEnhancer Elements, Genetic - Geneticsen_US
dc.subject.meshGene Expression Regulationen_US
dc.subject.meshInsect Hormones - Geneticsen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshPromoter Regions, Genetic - Geneticsen_US
dc.subject.meshProtein Bindingen_US
dc.subject.meshSequence Deletionen_US
dc.subject.meshTranscription Factors - Metabolismen_US
dc.subject.meshTranscription, Geneticen_US
dc.titleThe decapentaplegic core promoter region plays an integral role in the spatial control of transcriptionen_US
dc.typeArticleen_US
dc.identifier.emailHuang, JD:jdhuang@hkucc.hku.hken_US
dc.identifier.authorityHuang, JD=rp00451en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid7791801-
dc.identifier.scopuseid_2-s2.0-0029063614en_US
dc.identifier.volume15en_US
dc.identifier.issue7en_US
dc.identifier.spage3960en_US
dc.identifier.epage3968en_US
dc.identifier.isiWOS:A1995RE03000054-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridSchwyter, DH=6507993446en_US
dc.identifier.scopusauthoridHuang, JD=8108660600en_US
dc.identifier.scopusauthoridDubnicoff, T=6506930007en_US
dc.identifier.scopusauthoridCourey, AJ=7003350876en_US

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