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Article: The mRNAs for the three chains of human collagen type XI are widely distributed but not necessarily co-expressed: Implications for homotrimeric, heterotrimeric and heterotypic collagen molecules

TitleThe mRNAs for the three chains of human collagen type XI are widely distributed but not necessarily co-expressed: Implications for homotrimeric, heterotrimeric and heterotypic collagen molecules
Authors
Issue Date1995
PublisherPortland Press Ltd. The Journal's web site is located at http://www.biochemj.org
Citation
Biochemical Journal, 1995, v. 311 n. 2, p. 511-516 How to Cite?
AbstractIn cartilage collagen type XI exists as heterotrimeric molecules composed of α1(XI), α2(XI) and α3(XI) subunits. Messenger RNAs for some of the α chains of collagen type XI have also been found in non-chondrogenic tissues but the chain composition of the molecule in these sites is not known. Some non-chondrogenic tissues also contain heterotrimers containing collagen α2(V) and α1(XI) chains. We have explored the possibility that collagen type XI could exist in differing trimeric forms in non-chondrogenic tissues and aimed to predict the subunit composition of this collagen in those tissues. The distribution and relative levels of expression of collagen α1(XI), α2(XI) and α3(XI)/α1(II) mRNAs in different human fetal tissues were studied. Expression of mRNAs for all three genes of collagen type XI is not restricted to cartilage but is widespread. However, in some non-chondrogenic tissues, the mRNAs for all three α chains of collagen type XI were not co-expressed, but collagen α1(XI) and α2(XI) mRNAs were found either singly or without collagen α3(XI) transcripts. Collagen type XI may therefore exist as homotrimers and/or heterotrimers composed of two collagen α(XI) chains in some tissues. The distribution of mRNAs for collagen α2(V) and α1(I) were also studied. Co-expression of collagen type XI, α2(V) and α1(I) mRNAs was found for many tissues. These findings have implications for the possibility of additional chain associations for collagen types XI and V in cross-type heterotrimers within heterotypic fibrils.
Persistent Identifierhttp://hdl.handle.net/10722/147392
ISSN
2015 Impact Factor: 3.562
2015 SCImago Journal Rankings: 2.582
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLui, VCHen_HK
dc.contributor.authorKong, RYGen_HK
dc.contributor.authorNicholls, Jen_HK
dc.contributor.authorCheung, ANYen_HK
dc.contributor.authorCheah, KSEen_HK
dc.date.accessioned2012-05-29T06:03:23Z-
dc.date.available2012-05-29T06:03:23Z-
dc.date.issued1995en_HK
dc.identifier.citationBiochemical Journal, 1995, v. 311 n. 2, p. 511-516en_HK
dc.identifier.issn0264-6021en_HK
dc.identifier.urihttp://hdl.handle.net/10722/147392-
dc.description.abstractIn cartilage collagen type XI exists as heterotrimeric molecules composed of α1(XI), α2(XI) and α3(XI) subunits. Messenger RNAs for some of the α chains of collagen type XI have also been found in non-chondrogenic tissues but the chain composition of the molecule in these sites is not known. Some non-chondrogenic tissues also contain heterotrimers containing collagen α2(V) and α1(XI) chains. We have explored the possibility that collagen type XI could exist in differing trimeric forms in non-chondrogenic tissues and aimed to predict the subunit composition of this collagen in those tissues. The distribution and relative levels of expression of collagen α1(XI), α2(XI) and α3(XI)/α1(II) mRNAs in different human fetal tissues were studied. Expression of mRNAs for all three genes of collagen type XI is not restricted to cartilage but is widespread. However, in some non-chondrogenic tissues, the mRNAs for all three α chains of collagen type XI were not co-expressed, but collagen α1(XI) and α2(XI) mRNAs were found either singly or without collagen α3(XI) transcripts. Collagen type XI may therefore exist as homotrimers and/or heterotrimers composed of two collagen α(XI) chains in some tissues. The distribution of mRNAs for collagen α2(V) and α1(I) were also studied. Co-expression of collagen type XI, α2(V) and α1(I) mRNAs was found for many tissues. These findings have implications for the possibility of additional chain associations for collagen types XI and V in cross-type heterotrimers within heterotypic fibrils.en_HK
dc.languageengen_US
dc.publisherPortland Press Ltd. The Journal's web site is located at http://www.biochemj.orgen_HK
dc.relation.ispartofBiochemical Journalen_HK
dc.subject.meshCartilage - Cytology - Embryology - Metabolismen_US
dc.subject.meshCells, Cultureden_US
dc.subject.meshCollagen - Biosynthesis - Classification - Geneticsen_US
dc.subject.meshElectrophoresis, Agar Gelen_US
dc.subject.meshEmbryonic And Fetal Development - Physiologyen_US
dc.subject.meshFetus - Metabolismen_US
dc.subject.meshGene Expressionen_US
dc.subject.meshGestational Ageen_US
dc.subject.meshHumansen_US
dc.subject.meshPlasmidsen_US
dc.subject.meshRna - Isolation & Purificationen_US
dc.subject.meshRna, Messenger - Biosynthesis - Metabolismen_US
dc.subject.meshTissue Distributionen_US
dc.titleThe mRNAs for the three chains of human collagen type XI are widely distributed but not necessarily co-expressed: Implications for homotrimeric, heterotrimeric and heterotypic collagen moleculesen_HK
dc.typeArticleen_HK
dc.identifier.emailLui, VCH: vchlui@hkucc.hku.hken_HK
dc.identifier.emailNicholls, J: nicholls@pathology.hku.hken_HK
dc.identifier.emailCheung, ANY: anycheun@hkucc.hku.hken_HK
dc.identifier.emailCheah, KSE: hrmbdkc@hku.hken_HK
dc.identifier.authorityLui, VCH=rp00363en_HK
dc.identifier.authorityNicholls, J=rp00364en_HK
dc.identifier.authorityCheung, ANY=rp00542en_HK
dc.identifier.authorityCheah, KSE=rp00342en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid7487888-
dc.identifier.scopuseid_2-s2.0-0028827055en_HK
dc.identifier.hkuros14073-
dc.identifier.volume311en_HK
dc.identifier.issue2en_HK
dc.identifier.spage511en_HK
dc.identifier.epage516en_HK
dc.identifier.isiWOS:A1995TA25800021-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLui, VCH=7004231344en_HK
dc.identifier.scopusauthoridKong, RYG=7005290807en_HK
dc.identifier.scopusauthoridNicholls, J=7201463077en_HK
dc.identifier.scopusauthoridCheung, ANY=54927484100en_HK
dc.identifier.scopusauthoridCheah, KSE=35387746200en_HK

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