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Article: The α2(XI) collagen gene lies within 8 kb of Pb in the proximal portion of the murine major histocompatibility complex

TitleThe α2(XI) collagen gene lies within 8 kb of Pb in the proximal portion of the murine major histocompatibility complex
Authors
Issue Date1993
PublisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00335/
Citation
Mammalian Genome, 1993, v. 4 n. 2, p. 95-103 How to Cite?
AbstractA number of serious hereditary disorders are now known to be associated with defective expression of collagen genes, and these findings have underscored the important and varied roles that the collagen family of genes must play during normal mammalian development. Although the activities of genes encoding the quantitatively major types of collagen are fairly well characterized, functions of the many minor types of collagen remain a matter of speculation. As a first step toward a functional analysis of type XI collagen, a member of this class of poorly understand "minor" collagen proteins which is expressed primarily in hyaline cartilage, we have used human probes for the gene encoding the protein's α2-subunit (COL11A2) to isolate and map homologous murine DNA sequences. Our results demonstrate that Col11a-2 is embedded within the major histocompatibility complex (MHC), within 8.4 kb of the class II pseudogene locus, Pb, and confirm that human and murine α2(XI) collagen genes are located in very similar genomic environments. The conserved location of these genes raises the possibility that type XI collagen genes may contribute to one or more of the diverse hereditary disorders known to be linked to the MHC in mouse and human. © 1993 Springer-Verlag New York Inc.
Persistent Identifierhttp://hdl.handle.net/10722/147381
ISSN
2015 Impact Factor: 2.078
2015 SCImago Journal Rankings: 2.082
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorStubbs, Len_HK
dc.contributor.authorLui, VCHen_HK
dc.contributor.authorJim Ng, Len_HK
dc.contributor.authorCheah, KSEen_HK
dc.date.accessioned2012-05-29T06:03:18Z-
dc.date.available2012-05-29T06:03:18Z-
dc.date.issued1993en_HK
dc.identifier.citationMammalian Genome, 1993, v. 4 n. 2, p. 95-103en_HK
dc.identifier.issn0938-8990en_HK
dc.identifier.urihttp://hdl.handle.net/10722/147381-
dc.description.abstractA number of serious hereditary disorders are now known to be associated with defective expression of collagen genes, and these findings have underscored the important and varied roles that the collagen family of genes must play during normal mammalian development. Although the activities of genes encoding the quantitatively major types of collagen are fairly well characterized, functions of the many minor types of collagen remain a matter of speculation. As a first step toward a functional analysis of type XI collagen, a member of this class of poorly understand "minor" collagen proteins which is expressed primarily in hyaline cartilage, we have used human probes for the gene encoding the protein's α2-subunit (COL11A2) to isolate and map homologous murine DNA sequences. Our results demonstrate that Col11a-2 is embedded within the major histocompatibility complex (MHC), within 8.4 kb of the class II pseudogene locus, Pb, and confirm that human and murine α2(XI) collagen genes are located in very similar genomic environments. The conserved location of these genes raises the possibility that type XI collagen genes may contribute to one or more of the diverse hereditary disorders known to be linked to the MHC in mouse and human. © 1993 Springer-Verlag New York Inc.en_HK
dc.languageengen_US
dc.publisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00335/en_HK
dc.relation.ispartofMammalian Genomeen_HK
dc.subject.meshAmino Acid Sequenceen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBase Sequenceen_US
dc.subject.meshChromosome Mappingen_US
dc.subject.meshCollagen - Geneticsen_US
dc.subject.meshCosmidsen_US
dc.subject.meshCrosses, Geneticen_US
dc.subject.meshDnaen_US
dc.subject.meshMajor Histocompatibility Complex - Geneticsen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Inbred C57blen_US
dc.subject.meshMice, Inbred Dbaen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshPseudogenesen_US
dc.subject.meshSequence Homology, Amino Aciden_US
dc.subject.meshSequence Homology, Nucleic Aciden_US
dc.titleThe α2(XI) collagen gene lies within 8 kb of Pb in the proximal portion of the murine major histocompatibility complexen_HK
dc.typeArticleen_HK
dc.identifier.emailLui, VCH: vchlui@hkucc.hku.hken_HK
dc.identifier.emailCheah, KSE: hrmbdkc@hku.hken_HK
dc.identifier.authorityLui, VCH=rp00363en_HK
dc.identifier.authorityCheah, KSE=rp00342en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/BF00290433en_HK
dc.identifier.pmid8431643-
dc.identifier.scopuseid_2-s2.0-0027344203en_HK
dc.identifier.volume4en_HK
dc.identifier.issue2en_HK
dc.identifier.spage95en_HK
dc.identifier.epage103en_HK
dc.identifier.isiWOS:A1993KH45900005-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridStubbs, L=7006540193en_HK
dc.identifier.scopusauthoridLui, VCH=7004231344en_HK
dc.identifier.scopusauthoridJim Ng, L=16447542300en_HK
dc.identifier.scopusauthoridCheah, KSE=35387746200en_HK

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