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Article: Gene elav of Drosophila melanogaster: A prototype for neuronal-specific RNA binding protein gene family that is conserved in flies and humans

TitleGene elav of Drosophila melanogaster: A prototype for neuronal-specific RNA binding protein gene family that is conserved in flies and humans
Authors
Issue Date1993
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/31737
Citation
Journal Of Neurobiology, 1993, v. 24 n. 6, p. 723-739 How to Cite?
AbstractRegulated gene activity is crucial to the formation and function of the nervous system. It is well known that gene regulation can occur at the transcriptional, post-transcriptional, translational, and post-translational levels. In this review our focus has been on the post-transcriptional regulation in neurons and on neural-specific RNA binding proteins that may be involved in post-transcriptional modulation of gene activity. We have taken advantage of this opportunity to review our work on the elav gene of Drosophila melanogaster which encodes a neural-specific RNA binding protein and relate it to other members of this elav-like gene family. We report new data that suggests that elav is post-transcriptionally regulated and we demonstrate that below-threshold levels of ELAV protein severely affects neuronal differentiation.
Persistent Identifierhttp://hdl.handle.net/10722/147380
ISSN
2008 Impact Factor: 3.84
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYao, KMen_US
dc.contributor.authorSamson, MLen_US
dc.contributor.authorReeves, Ren_US
dc.contributor.authorWhite, Ken_US
dc.date.accessioned2012-05-29T06:03:18Z-
dc.date.available2012-05-29T06:03:18Z-
dc.date.issued1993en_US
dc.identifier.citationJournal Of Neurobiology, 1993, v. 24 n. 6, p. 723-739en_US
dc.identifier.issn0022-3034en_US
dc.identifier.urihttp://hdl.handle.net/10722/147380-
dc.description.abstractRegulated gene activity is crucial to the formation and function of the nervous system. It is well known that gene regulation can occur at the transcriptional, post-transcriptional, translational, and post-translational levels. In this review our focus has been on the post-transcriptional regulation in neurons and on neural-specific RNA binding proteins that may be involved in post-transcriptional modulation of gene activity. We have taken advantage of this opportunity to review our work on the elav gene of Drosophila melanogaster which encodes a neural-specific RNA binding protein and relate it to other members of this elav-like gene family. We report new data that suggests that elav is post-transcriptionally regulated and we demonstrate that below-threshold levels of ELAV protein severely affects neuronal differentiation.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/31737en_US
dc.relation.ispartofJournal of Neurobiologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshDrosophila Melanogaster - Geneticsen_US
dc.subject.meshGene Expression Regulationen_US
dc.subject.meshHumansen_US
dc.subject.meshMultigene Familyen_US
dc.subject.meshMutationen_US
dc.subject.meshNerve Tissue Proteins - Geneticsen_US
dc.subject.meshNeurons - Metabolismen_US
dc.subject.meshRna, Messenger - Geneticsen_US
dc.subject.meshRna-Binding Proteins - Geneticsen_US
dc.titleGene elav of Drosophila melanogaster: A prototype for neuronal-specific RNA binding protein gene family that is conserved in flies and humansen_US
dc.typeArticleen_US
dc.identifier.emailYao, KM:kmyao@hku.hken_US
dc.identifier.authorityYao, KM=rp00344en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/neu.480240604en_US
dc.identifier.pmid8331337-
dc.identifier.scopuseid_2-s2.0-0027309573en_US
dc.identifier.volume24en_US
dc.identifier.issue6en_US
dc.identifier.spage723en_US
dc.identifier.epage739en_US
dc.identifier.isiWOS:A1993LE15500003-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridYao, KM=7403234578en_US
dc.identifier.scopusauthoridSamson, ML=7103252061en_US
dc.identifier.scopusauthoridReeves, R=7202150664en_US
dc.identifier.scopusauthoridWhite, K=35569872100en_US

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