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Article: Epitope specificity of antibodies to type II collagen in rheumatoid arthritis and systemic lupus erythematosus

TitleEpitope specificity of antibodies to type II collagen in rheumatoid arthritis and systemic lupus erythematosus
Authors
Issue Date1992
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00296/index.htm
Citation
Rheumatology International, 1992, v. 12 n. 2, p. 65-69 How to Cite?
Abstract
Antibodies to human type II collagen were examined in the sera of 105 patients with rheumatoid arthritis (RA), 44 patients with systemic lupus erythematosus (SEF) and 11 patients who fulfilled the criteria of both diseases (RA-SLE overlap), using a solid-phase radioimmunoassay (RIA). The frequencies of antibodies to native and denatured human type II collagen were 20% and 27% in RA, 14% and 16% in SLE, and 45% and 36% in RA-SLE overlap. The specificity of the antibodies was further examined by inhibition with native and denatured type II collagen, by immunoblotting on native and denatured type II collagen, and by immunoblotting on cyanogen-bromide derived polypeptides of type II collagen. We could not identify any disease-specific patterns of reactivity. Thus, in the three disease groups the antibody response was polyclonal; there were antibody populations that reacted with native and/or denatured collagen, and epitopes could be assigned to at least three CB peptides, CB10.5, CB11 and CB8.
Persistent Identifierhttp://hdl.handle.net/10722/147370
ISSN
2013 Impact Factor: 1.627
ISI Accession Number ID

 

Author Affiliations
  1. Monash University
DC FieldValueLanguage
dc.contributor.authorRowley, MJen_US
dc.contributor.authorMackay, IRen_US
dc.contributor.authorBrand, CAen_US
dc.contributor.authorBateman, JFen_US
dc.contributor.authorChan, Den_US
dc.date.accessioned2012-05-29T06:03:14Z-
dc.date.available2012-05-29T06:03:14Z-
dc.date.issued1992en_US
dc.identifier.citationRheumatology International, 1992, v. 12 n. 2, p. 65-69en_US
dc.identifier.issn0172-8172en_US
dc.identifier.urihttp://hdl.handle.net/10722/147370-
dc.description.abstractAntibodies to human type II collagen were examined in the sera of 105 patients with rheumatoid arthritis (RA), 44 patients with systemic lupus erythematosus (SEF) and 11 patients who fulfilled the criteria of both diseases (RA-SLE overlap), using a solid-phase radioimmunoassay (RIA). The frequencies of antibodies to native and denatured human type II collagen were 20% and 27% in RA, 14% and 16% in SLE, and 45% and 36% in RA-SLE overlap. The specificity of the antibodies was further examined by inhibition with native and denatured type II collagen, by immunoblotting on native and denatured type II collagen, and by immunoblotting on cyanogen-bromide derived polypeptides of type II collagen. We could not identify any disease-specific patterns of reactivity. Thus, in the three disease groups the antibody response was polyclonal; there were antibody populations that reacted with native and/or denatured collagen, and epitopes could be assigned to at least three CB peptides, CB10.5, CB11 and CB8.en_US
dc.languageengen_US
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00296/index.htmen_US
dc.relation.ispartofRheumatology Internationalen_US
dc.subject.meshAntibodies - Analysis - Immunologyen_US
dc.subject.meshAntibody Specificityen_US
dc.subject.meshArthritis, Rheumatoid - Blood - Diagnosis - Immunologyen_US
dc.subject.meshBiological Markers - Blooden_US
dc.subject.meshCollagen - Immunologyen_US
dc.subject.meshEpitopes - Immunologyen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunoblottingen_US
dc.subject.meshLupus Erythematosus, Systemic - Blood - Diagnosis - Immunologyen_US
dc.subject.meshRadioimmunoassayen_US
dc.titleEpitope specificity of antibodies to type II collagen in rheumatoid arthritis and systemic lupus erythematosusen_US
dc.typeArticleen_US
dc.identifier.emailChan, D:chand@hkucc.hku.hken_US
dc.identifier.authorityChan, D=rp00540en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/BF00300979en_US
dc.identifier.pmid1384102en_US
dc.identifier.scopuseid_2-s2.0-0026659023en_US
dc.identifier.volume12en_US
dc.identifier.issue2en_US
dc.identifier.spage65en_US
dc.identifier.epage69en_US
dc.identifier.isiWOS:A1992JA83300005-
dc.publisher.placeGermanyen_US
dc.identifier.scopusauthoridRowley, MJ=7101677429en_US
dc.identifier.scopusauthoridMackay, IR=24923115500en_US
dc.identifier.scopusauthoridBrand, CA=7102268328en_US
dc.identifier.scopusauthoridBateman, JF=16135557700en_US
dc.identifier.scopusauthoridChan, D=7402216545en_US

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