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Article: A distinct Hox code for the branchial region of the vertebrate head

TitleA distinct Hox code for the branchial region of the vertebrate head
Authors
Issue Date1991
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/nature
Citation
Nature, 1991, v. 353 n. 6347, p. 861-864 How to Cite?
AbstractThe branchial region of the vertebrate head forms through complex interactions involving rhombomeric segments, neural crest and branchial arches. It is thought that aspects of their patterning mechanisms are linked and involve Hox-2 genes, whose overlapping and spatially restricted expression domains represent a combinatorial code for generating regional diversity. Vertebrates possess four Hox clusters of Antennapedia class homeobox genes, related to each other by duplication and divergence from a common ancestral complex. In consequence, at equivalent positions in different clusters there are highly related genes known as subfamilies or paralogous groups. As Hox-2 genes cannot fully account for patterning individual rhombomeres, we investigated whether offsets in expression limits of paralogous genes could account for the generation of regional diversity. We report here that, with the exception of the labial subfamily, paralogues show identical expression limits in rhombomeres, cranial ganglia and branchial arches, providing a combinatorial Hox code for the branchial region that seems to be different in organization to that of the trunk.
Persistent Identifierhttp://hdl.handle.net/10722/147361
ISSN
2015 Impact Factor: 38.138
2015 SCImago Journal Rankings: 21.936
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHunt, Pen_US
dc.contributor.authorGulisano, Men_US
dc.contributor.authorCook, Men_US
dc.contributor.authorSham, MHen_US
dc.contributor.authorFaiella, Aen_US
dc.contributor.authorWilkinson, Den_US
dc.contributor.authorBoncinelli, Een_US
dc.contributor.authorKrumlauf, Ren_US
dc.date.accessioned2012-05-29T06:03:11Z-
dc.date.available2012-05-29T06:03:11Z-
dc.date.issued1991en_US
dc.identifier.citationNature, 1991, v. 353 n. 6347, p. 861-864en_US
dc.identifier.issn0028-0836en_US
dc.identifier.urihttp://hdl.handle.net/10722/147361-
dc.description.abstractThe branchial region of the vertebrate head forms through complex interactions involving rhombomeric segments, neural crest and branchial arches. It is thought that aspects of their patterning mechanisms are linked and involve Hox-2 genes, whose overlapping and spatially restricted expression domains represent a combinatorial code for generating regional diversity. Vertebrates possess four Hox clusters of Antennapedia class homeobox genes, related to each other by duplication and divergence from a common ancestral complex. In consequence, at equivalent positions in different clusters there are highly related genes known as subfamilies or paralogous groups. As Hox-2 genes cannot fully account for patterning individual rhombomeres, we investigated whether offsets in expression limits of paralogous genes could account for the generation of regional diversity. We report here that, with the exception of the labial subfamily, paralogues show identical expression limits in rhombomeres, cranial ganglia and branchial arches, providing a combinatorial Hox code for the branchial region that seems to be different in organization to that of the trunk.en_US
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/natureen_US
dc.relation.ispartofNatureen_US
dc.subject.meshAllelesen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBrain - Anatomy & Histology - Embryologyen_US
dc.subject.meshEmbryo, Mammalianen_US
dc.subject.meshGene Expressionen_US
dc.subject.meshGenes, Homeoboxen_US
dc.subject.meshGestational Ageen_US
dc.subject.meshMesencephalon - Anatomy & Histology - Embryologyen_US
dc.subject.meshMice - Anatomy & Histology - Geneticsen_US
dc.subject.meshRhombencephalon - Anatomy & Histology - Embryologyen_US
dc.subject.meshSpinal Cord - Anatomy & Histology - Embryologyen_US
dc.titleA distinct Hox code for the branchial region of the vertebrate headen_US
dc.typeArticleen_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1038/353861a0en_US
dc.identifier.pmid1682814en_US
dc.identifier.scopuseid_2-s2.0-0025952742en_US
dc.identifier.volume353en_US
dc.identifier.issue6347en_US
dc.identifier.spage861en_US
dc.identifier.epage864en_US
dc.identifier.isiWOS:A1991GM73200065-
dc.publisher.placeUnited Kingdomen_US

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