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Article: The gene for the α2 chain of the human fibrillar collagen type XI (COL11A2) assigned to the short arm of chromosome 6

TitleThe gene for the α2 chain of the human fibrillar collagen type XI (COL11A2) assigned to the short arm of chromosome 6
Authors
Issue Date1990
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/AHG
Citation
Annals Of Human Genetics, 1990, v. 54 n. 1, p. 23-29 How to Cite?
AbstractA cosmid clone (CosHcol.11) containing the α2(XI) collagen gene (COL11A2) has been isolated. The gene contains conserved DNA and amino-acid sequences characteristic of fibril forming collagen, which is in accordance with the classification of type XI collagen as a fibrillar collagen. The genomic clone containing the α2(XI) gene has been used as probe in the Southern blot analysis of DNA from a panel of human/hamster somatic cell hybrids containing different numbers and combinations of human chromosomes. Synteny analysis revealed that only chromosome 6 showed complete concordant segregation with COL11A2. Furthermore, the gene was regionally mapped to the short arm of chromosome 6 by using a hybrid which contained only the long arm of the chromosome.
Persistent Identifierhttp://hdl.handle.net/10722/147346
ISSN
2015 Impact Factor: 1.889
2015 SCImago Journal Rankings: 1.191
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLaw, MLen_US
dc.contributor.authorChan, SDHen_US
dc.contributor.authorBerger, Ren_US
dc.contributor.authorJones, Cen_US
dc.contributor.authorKao, FTen_US
dc.contributor.authorSolomon, Een_US
dc.contributor.authorCheah, KSEen_US
dc.date.accessioned2012-05-29T06:03:05Z-
dc.date.available2012-05-29T06:03:05Z-
dc.date.issued1990en_US
dc.identifier.citationAnnals Of Human Genetics, 1990, v. 54 n. 1, p. 23-29en_US
dc.identifier.issn0003-4800en_US
dc.identifier.urihttp://hdl.handle.net/10722/147346-
dc.description.abstractA cosmid clone (CosHcol.11) containing the α2(XI) collagen gene (COL11A2) has been isolated. The gene contains conserved DNA and amino-acid sequences characteristic of fibril forming collagen, which is in accordance with the classification of type XI collagen as a fibrillar collagen. The genomic clone containing the α2(XI) gene has been used as probe in the Southern blot analysis of DNA from a panel of human/hamster somatic cell hybrids containing different numbers and combinations of human chromosomes. Synteny analysis revealed that only chromosome 6 showed complete concordant segregation with COL11A2. Furthermore, the gene was regionally mapped to the short arm of chromosome 6 by using a hybrid which contained only the long arm of the chromosome.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/AHGen_US
dc.relation.ispartofAnnals of Human Geneticsen_US
dc.subject.meshBlotting, Southernen_US
dc.subject.meshChromosome Mappingen_US
dc.subject.meshChromosomes, Human, Pair 6en_US
dc.subject.meshCollagen - Geneticsen_US
dc.subject.meshDnaen_US
dc.subject.meshExtracellular Matrixen_US
dc.subject.meshHumansen_US
dc.subject.meshNucleic Acid Hybridizationen_US
dc.titleThe gene for the α2 chain of the human fibrillar collagen type XI (COL11A2) assigned to the short arm of chromosome 6en_US
dc.typeArticleen_US
dc.identifier.emailCheah, KSE:hrmbdkc@hku.hken_US
dc.identifier.authorityCheah, KSE=rp00342en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid2321911-
dc.identifier.scopuseid_2-s2.0-0025034718en_US
dc.identifier.volume54en_US
dc.identifier.issue1en_US
dc.identifier.spage23en_US
dc.identifier.epage29en_US
dc.identifier.isiWOS:A1990CN93100003-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridLaw, ML=7202652161en_US
dc.identifier.scopusauthoridChan, SDH=36901176300en_US
dc.identifier.scopusauthoridBerger, R=7403562884en_US
dc.identifier.scopusauthoridJones, C=7408261676en_US
dc.identifier.scopusauthoridKao, FT=7006525127en_US
dc.identifier.scopusauthoridSolomon, E=7201615395en_US
dc.identifier.scopusauthoridCheah, KSE=35387746200en_US

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