File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: The human α2(XI) collagen gene (COL11A2) maps to the centromeric border of the major histocompatibility complex on chromosome 6

TitleThe human α2(XI) collagen gene (COL11A2) maps to the centromeric border of the major histocompatibility complex on chromosome 6
Authors
Issue Date1989
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ygeno
Citation
Genomics, 1989, v. 5 n. 4, p. 925-931 How to Cite?
AbstractType XI collagen, a minor structural component of cartilage fibrils, is composed of three chains, α1(XI), α2(XI), and α3(XI). Using a cloned fragment of the human α2(XI) collagen gene (COL11A2) as a molecular probe for in situ hybridization and somatic cell hybrid mapping, we have localized the gene to the short arm of chromosome 6, region 21.3. By exploiting the rich source of probes provided by the major histocompatibility complex (MHC) genes, which also map to this chromosomal band, we have constructed macrorestriction maps of the region by pulsed-field gel electrophoresis and have localized the α2(XI) collagen gene to the centromeric extreme of the MHC. Finally, we have demonstrated, by the isolation of overlapping cosmid clones, that the gene is 45 kb centromeric to the HLA-DPB2 locus and oriented with the 3′ end toward the MHC. The COL11A2 locus thus demarcates the proximal boundary of the MHC. This finding may have implications for the understanding of certain MHC-linked diseases. © 1989.
Persistent Identifierhttp://hdl.handle.net/10722/147342
ISSN
2015 Impact Factor: 2.386
2015 SCImago Journal Rankings: 1.281
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHanson, IMen_HK
dc.contributor.authorGorman, Pen_HK
dc.contributor.authorLui, VCHen_HK
dc.contributor.authorCheah, KSEen_HK
dc.contributor.authorSolomon, Een_HK
dc.contributor.authorTrowsdale, Jen_HK
dc.date.accessioned2012-05-29T06:03:03Z-
dc.date.available2012-05-29T06:03:03Z-
dc.date.issued1989en_HK
dc.identifier.citationGenomics, 1989, v. 5 n. 4, p. 925-931en_HK
dc.identifier.issn0888-7543en_HK
dc.identifier.urihttp://hdl.handle.net/10722/147342-
dc.description.abstractType XI collagen, a minor structural component of cartilage fibrils, is composed of three chains, α1(XI), α2(XI), and α3(XI). Using a cloned fragment of the human α2(XI) collagen gene (COL11A2) as a molecular probe for in situ hybridization and somatic cell hybrid mapping, we have localized the gene to the short arm of chromosome 6, region 21.3. By exploiting the rich source of probes provided by the major histocompatibility complex (MHC) genes, which also map to this chromosomal band, we have constructed macrorestriction maps of the region by pulsed-field gel electrophoresis and have localized the α2(XI) collagen gene to the centromeric extreme of the MHC. Finally, we have demonstrated, by the isolation of overlapping cosmid clones, that the gene is 45 kb centromeric to the HLA-DPB2 locus and oriented with the 3′ end toward the MHC. The COL11A2 locus thus demarcates the proximal boundary of the MHC. This finding may have implications for the understanding of certain MHC-linked diseases. © 1989.en_HK
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ygenoen_HK
dc.relation.ispartofGenomicsen_HK
dc.subject.meshCentromereen_US
dc.subject.meshChromosome Bandingen_US
dc.subject.meshChromosome Mappingen_US
dc.subject.meshChromosomesen_US
dc.subject.meshChromosomes, Human, Pair 6en_US
dc.subject.meshCollagen - Geneticsen_US
dc.subject.meshCosmidsen_US
dc.subject.meshElectrophoresis, Agar Gelen_US
dc.subject.meshHumansen_US
dc.subject.meshMajor Histocompatibility Complex - Geneticsen_US
dc.subject.meshRestriction Mappingen_US
dc.titleThe human α2(XI) collagen gene (COL11A2) maps to the centromeric border of the major histocompatibility complex on chromosome 6en_HK
dc.typeArticleen_HK
dc.identifier.emailLui, VCH: vchlui@hkucc.hku.hken_HK
dc.identifier.emailCheah, KSE: hrmbdkc@hku.hken_HK
dc.identifier.authorityLui, VCH=rp00363en_HK
dc.identifier.authorityCheah, KSE=rp00342en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid2591970-
dc.identifier.scopuseid_2-s2.0-0024761085en_HK
dc.identifier.volume5en_HK
dc.identifier.issue4en_HK
dc.identifier.spage925en_HK
dc.identifier.epage931en_HK
dc.identifier.isiWOS:A1989AZ32800030-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridHanson, IM=7006045156en_HK
dc.identifier.scopusauthoridGorman, P=35407203100en_HK
dc.identifier.scopusauthoridLui, VCH=7004231344en_HK
dc.identifier.scopusauthoridCheah, KSE=35387746200en_HK
dc.identifier.scopusauthoridSolomon, E=7201615395en_HK
dc.identifier.scopusauthoridTrowsdale, J=7102329772en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats