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Article: Demonstration of calcium oxalate crystallization-enhancing activity of urinary macromolecules with a gel model

TitleDemonstration of calcium oxalate crystallization-enhancing activity of urinary macromolecules with a gel model
Authors
Issue Date1989
PublisherChapman & Hall, Journals Department. The Journal's web site is located at http://www.chaphall.com/chaphall/journals.html
Citation
Medical Science Research, 1989, v. 17 n. 6, p. 297-298 How to Cite?
AbstractThe influence of urinary macromolecules of nucleating calcium oxalate crystallites trapped in a matrix was studied in an agarose gel medium. The mean inhibitory activity (I) of concentrated whole urine (1,200 mOsmol/kg) differentiates the population into two groups: a high activity groups (H, 63% of stone formers, 23% of normal controls; I = 0.64) and a low activity group (L, 37% of stone formers, 77% of normal controls: I = 0.27). Urinary macromolecules concentrated by ultrafiltration at a nominal cutoff of 5 kDa resulted in increased crystallization. This contrasts with the purely inhibitory activity of the dextrans. The overall crystallization activity of whole urine is due therefore to the composite action of inhibiting as well as enhancing factors.
Persistent Identifierhttp://hdl.handle.net/10722/147341
ISSN
2001 Impact Factor: 0.384
2003 SCImago Journal Rankings: 0.107

 

DC FieldValueLanguage
dc.contributor.authorShum, DKYen_US
dc.contributor.authorLiong, Een_US
dc.contributor.authorLam, WMen_US
dc.date.accessioned2012-05-29T06:03:03Z-
dc.date.available2012-05-29T06:03:03Z-
dc.date.issued1989en_US
dc.identifier.citationMedical Science Research, 1989, v. 17 n. 6, p. 297-298en_US
dc.identifier.issn0269-8951en_US
dc.identifier.urihttp://hdl.handle.net/10722/147341-
dc.description.abstractThe influence of urinary macromolecules of nucleating calcium oxalate crystallites trapped in a matrix was studied in an agarose gel medium. The mean inhibitory activity (I) of concentrated whole urine (1,200 mOsmol/kg) differentiates the population into two groups: a high activity groups (H, 63% of stone formers, 23% of normal controls; I = 0.64) and a low activity group (L, 37% of stone formers, 77% of normal controls: I = 0.27). Urinary macromolecules concentrated by ultrafiltration at a nominal cutoff of 5 kDa resulted in increased crystallization. This contrasts with the purely inhibitory activity of the dextrans. The overall crystallization activity of whole urine is due therefore to the composite action of inhibiting as well as enhancing factors.en_US
dc.languageengen_US
dc.publisherChapman & Hall, Journals Department. The Journal's web site is located at http://www.chaphall.com/chaphall/journals.htmlen_US
dc.relation.ispartofMedical Science Researchen_US
dc.titleDemonstration of calcium oxalate crystallization-enhancing activity of urinary macromolecules with a gel modelen_US
dc.typeArticleen_US
dc.identifier.emailShum, DKY:shumdkhk@hkucc.hku.hken_US
dc.identifier.authorityShum, DKY=rp00321en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-0024542172en_US
dc.identifier.volume17en_US
dc.identifier.issue6en_US
dc.identifier.spage297en_US
dc.identifier.epage298en_US
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridShum, DKY=7004824447en_US
dc.identifier.scopusauthoridLiong, E=35938810100en_US
dc.identifier.scopusauthoridLam, WM=7203021895en_US

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