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Article: Identification and characterization of the human type II collagen gene (COL2A1)

TitleIdentification and characterization of the human type II collagen gene (COL2A1)
Authors
Issue Date1985
PublisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.org
Citation
Proceedings Of The National Academy Of Sciences Of The United States Of America, 1985, v. 82 n. 9, p. 2555-2559 How to Cite?
AbstractThe gene contained in the human cosmid clone CosHcol1, previously designated an α1(I) collagen-like gene, has now been identified. CosHcol1 hybridizes strongly to a single 5.9-kilobase mRNA species present only in tissue in which type II collagen is expressed. DNA sequence analysis shows that this clone is highly homologous to the chicken α1(II) collagen gene. These data together suggest that CosHcol1 contains the human α1(II) collagen gene COL2A1. The clone appears to contain the whole gene (30 kilobases in length) and will be extremely useful in the study of cartilage development and for identifying those inherited chondrodystrophies in which defects occur in this gene.
Persistent Identifierhttp://hdl.handle.net/10722/147313
ISSN
2015 Impact Factor: 9.423
2015 SCImago Journal Rankings: 6.883
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCheah, KSEen_US
dc.contributor.authorStoker, NGen_US
dc.contributor.authorGriffin, JRen_US
dc.date.accessioned2012-05-29T06:02:51Z-
dc.date.available2012-05-29T06:02:51Z-
dc.date.issued1985en_US
dc.identifier.citationProceedings Of The National Academy Of Sciences Of The United States Of America, 1985, v. 82 n. 9, p. 2555-2559en_US
dc.identifier.issn0027-8424en_US
dc.identifier.urihttp://hdl.handle.net/10722/147313-
dc.description.abstractThe gene contained in the human cosmid clone CosHcol1, previously designated an α1(I) collagen-like gene, has now been identified. CosHcol1 hybridizes strongly to a single 5.9-kilobase mRNA species present only in tissue in which type II collagen is expressed. DNA sequence analysis shows that this clone is highly homologous to the chicken α1(II) collagen gene. These data together suggest that CosHcol1 contains the human α1(II) collagen gene COL2A1. The clone appears to contain the whole gene (30 kilobases in length) and will be extremely useful in the study of cartilage development and for identifying those inherited chondrodystrophies in which defects occur in this gene.en_US
dc.languageengen_US
dc.publisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.orgen_US
dc.relation.ispartofProceedings of the National Academy of Sciences of the United States of Americaen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBase Sequenceen_US
dc.subject.meshChickens - Geneticsen_US
dc.subject.meshChromosome Mappingen_US
dc.subject.meshCloning, Molecularen_US
dc.subject.meshCollagen - Geneticsen_US
dc.subject.meshGenesen_US
dc.subject.meshHumansen_US
dc.subject.meshRna, Messenger - Geneticsen_US
dc.subject.meshSpecies Specificityen_US
dc.titleIdentification and characterization of the human type II collagen gene (COL2A1)en_US
dc.typeArticleen_US
dc.identifier.emailCheah, KSE:hrmbdkc@hku.hken_US
dc.identifier.authorityCheah, KSE=rp00342en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid3857598-
dc.identifier.scopuseid_2-s2.0-0022003806en_US
dc.identifier.volume82en_US
dc.identifier.issue9en_US
dc.identifier.spage2555en_US
dc.identifier.epage2559en_US
dc.identifier.isiWOS:A1985AGW3200001-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridCheah, KSE=35387746200en_US
dc.identifier.scopusauthoridStoker, NG=7005862690en_US
dc.identifier.scopusauthoridGriffin, JR=7403422539en_US

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