File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Chemical modification of hemoglobin in intact whole cells: Morphological studies by scanning electron microscope

TitleChemical modification of hemoglobin in intact whole cells: Morphological studies by scanning electron microscope
Authors
Issue Date1982
Citation
International Journal Of Biochemistry, 1982, v. 14 n. 6, p. 461-465 How to Cite?
AbstractWhole blood was incubated in physiological conditions with a variety of modifiers capable of modifying hemoglobin. Some of these compounds have been considered as therapeutic agents for certain hemoglobinopathies such as sickle-cell disease. The extent of modification on hemoglobin was estimated by electrophoresis and the red-cell morphology by scanning electron microscope. Results indicated that carbamyl phosphate, aspirin and glutaryl-salicylamide had no observable effect, whereas cross-linkers in general produced drastic changes in red-cell morphology. Dibromoaspirin, a very effective acetylating agent, produced abnormalities even in concentrations as low as 1 mM.
Persistent Identifierhttp://hdl.handle.net/10722/147304
ISSN
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCheng, LYLen_US
dc.contributor.authorTam, JWOen_US
dc.date.accessioned2012-05-29T06:02:48Z-
dc.date.available2012-05-29T06:02:48Z-
dc.date.issued1982en_US
dc.identifier.citationInternational Journal Of Biochemistry, 1982, v. 14 n. 6, p. 461-465en_US
dc.identifier.issn0020-711Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/147304-
dc.description.abstractWhole blood was incubated in physiological conditions with a variety of modifiers capable of modifying hemoglobin. Some of these compounds have been considered as therapeutic agents for certain hemoglobinopathies such as sickle-cell disease. The extent of modification on hemoglobin was estimated by electrophoresis and the red-cell morphology by scanning electron microscope. Results indicated that carbamyl phosphate, aspirin and glutaryl-salicylamide had no observable effect, whereas cross-linkers in general produced drastic changes in red-cell morphology. Dibromoaspirin, a very effective acetylating agent, produced abnormalities even in concentrations as low as 1 mM.en_US
dc.languageengen_US
dc.relation.ispartofInternational Journal of Biochemistryen_US
dc.subject.meshAnemia, Sickle Cell - Blooden_US
dc.subject.meshErythrocytes - Drug Effects - Ultrastructureen_US
dc.subject.meshHemoglobins, Abnormal - Metabolismen_US
dc.subject.meshHemolysis - Drug Effectsen_US
dc.subject.meshHumansen_US
dc.subject.meshMicroscopy, Electron, Scanningen_US
dc.titleChemical modification of hemoglobin in intact whole cells: Morphological studies by scanning electron microscopeen_US
dc.typeArticleen_US
dc.identifier.emailCheng, LYL:lcheng@hkucc.hku.hken_US
dc.identifier.authorityCheng, LYL=rp00317en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid7106347en_US
dc.identifier.scopuseid_2-s2.0-0020264362en_US
dc.identifier.volume14en_US
dc.identifier.issue6en_US
dc.identifier.spage461en_US
dc.identifier.epage465en_US
dc.identifier.isiWOS:A1982NV64500005-
dc.identifier.scopusauthoridCheng, LYL=7403337122en_US
dc.identifier.scopusauthoridTam, JWO=7102534616en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats