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Article: Alternative use of isoflurane and propofol confers superior cardioprotection than using one of them alone in a dog model of cardiopulmonary bypass
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TitleAlternative use of isoflurane and propofol confers superior cardioprotection than using one of them alone in a dog model of cardiopulmonary bypass
 
AuthorsLi, T3
Wu, W2
You, Z3
Zhou, R3
Li, Q3
Zhu, D3
Li, H3
Xiang, X3
Irwin, MG1
Xia, Z1
Liu, J3
 
KeywordsCardiopulmonary Bypass
Ischemia/Reperfusion Injury
Isoflurane
Oxidative Stress
Propofol
 
Issue Date2012
 
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejphar
 
CitationEuropean Journal Of Pharmacology, 2012, v. 677 n. 1-3, p. 138-146 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.ejphar.2011.12.030
 
AbstractOur previous clinical study reported that isoflurane preconditioning and high-dose propofol posttreatment attenuated myocardial ischemia/reperfusion injury of patients in surgery with cardiopulmonary bypass (CPB). This study was designed to confirm this cardiac protection by use of a dog CPB model and to elucidate the related mechanism. Adult mongrel male dogs undergoing standard CPB were assigned into 4 groups: Sham group, Propofol group, Isoflurane (Iso) group and isoflurane in combination of propofol (pre-Iso + P) group. After induction, anesthesia was maintained with propofol (Propofol group), isoflurane (Iso group) or isoflurane preconditioning in combination with propofol posttreatment (pre-Iso + P group). After 2 h cardiac arrest and CPB, aortic cross-clamping was released to allow 2 h reperfusion. The results demonstrated that joint use of isoflurane and propofol facilitated cardiac functional recovery, improved myocardial oxygen utilization and decreased cardiac enzyme release. Also, the oxidative damage caused by ischemia/reperfusion injury was remarkably attenuated. Linear regression analysis showed that cardiac function performance and oxidative stress status were inversely correlated, indicating the improved cardiac function was in closed association with the attenuation of oxidative stress. In addition, the cardiac oxygen consumption (VO 2) was found to be significantly associated with the above cardiac function and oxidative stress parameters, suggesting VO 2 was predictive for the levels of cardiac damage and oxidative stress. Therefore, we conclude that alternative use of isoflurane and propofol confers superior cardioprotection against postischemic myocardial injury and dysfunction, and this protection was probably mediated by attenuation of cardiac oxidative damage. © 2011 Elsevier B.V. All rights reserved.
 
ISSN0014-2999
2012 Impact Factor: 2.592
2012 SCImago Journal Rankings: 0.832
 
DOIhttp://dx.doi.org/10.1016/j.ejphar.2011.12.030
 
ISI Accession Number IDWOS:000300731200020
Funding AgencyGrant Number
National Nature Science Foundation of China81100180
30801083
81070117
China Postdoctoral Specialized Science Foundation201003700
Specialized Research Fund for the Doctoral Program of Higher Education20100181120090
Major Program of the Clinical High and New Technology of PLA2010gxjs039
Society of Cardiovascular Anesthesiologists (SCA)
Funding Information:

This study was supported by grants from the National Nature Science Foundation of China (81100180, 30801083 and 81070117), the China Postdoctoral Specialized Science Foundation (201003700), the Specialized Research Fund for the Doctoral Program of Higher Education (20100181120090), the Major Program of the Clinical High and New Technology of PLA (2010gxjs039) and The Society of Cardiovascular Anesthesiologists (SCA) research starter grant (2008 to Dr Xia).

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorLi, T
 
dc.contributor.authorWu, W
 
dc.contributor.authorYou, Z
 
dc.contributor.authorZhou, R
 
dc.contributor.authorLi, Q
 
dc.contributor.authorZhu, D
 
dc.contributor.authorLi, H
 
dc.contributor.authorXiang, X
 
dc.contributor.authorIrwin, MG
 
dc.contributor.authorXia, Z
 
dc.contributor.authorLiu, J
 
dc.date.accessioned2012-05-29T06:01:16Z
 
dc.date.available2012-05-29T06:01:16Z
 
dc.date.issued2012
 
dc.description.abstractOur previous clinical study reported that isoflurane preconditioning and high-dose propofol posttreatment attenuated myocardial ischemia/reperfusion injury of patients in surgery with cardiopulmonary bypass (CPB). This study was designed to confirm this cardiac protection by use of a dog CPB model and to elucidate the related mechanism. Adult mongrel male dogs undergoing standard CPB were assigned into 4 groups: Sham group, Propofol group, Isoflurane (Iso) group and isoflurane in combination of propofol (pre-Iso + P) group. After induction, anesthesia was maintained with propofol (Propofol group), isoflurane (Iso group) or isoflurane preconditioning in combination with propofol posttreatment (pre-Iso + P group). After 2 h cardiac arrest and CPB, aortic cross-clamping was released to allow 2 h reperfusion. The results demonstrated that joint use of isoflurane and propofol facilitated cardiac functional recovery, improved myocardial oxygen utilization and decreased cardiac enzyme release. Also, the oxidative damage caused by ischemia/reperfusion injury was remarkably attenuated. Linear regression analysis showed that cardiac function performance and oxidative stress status were inversely correlated, indicating the improved cardiac function was in closed association with the attenuation of oxidative stress. In addition, the cardiac oxygen consumption (VO 2) was found to be significantly associated with the above cardiac function and oxidative stress parameters, suggesting VO 2 was predictive for the levels of cardiac damage and oxidative stress. Therefore, we conclude that alternative use of isoflurane and propofol confers superior cardioprotection against postischemic myocardial injury and dysfunction, and this protection was probably mediated by attenuation of cardiac oxidative damage. © 2011 Elsevier B.V. All rights reserved.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationEuropean Journal Of Pharmacology, 2012, v. 677 n. 1-3, p. 138-146 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.ejphar.2011.12.030
 
dc.identifier.citeulike10190168
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.ejphar.2011.12.030
 
dc.identifier.epage146
 
dc.identifier.hkuros203045
 
dc.identifier.isiWOS:000300731200020
Funding AgencyGrant Number
National Nature Science Foundation of China81100180
30801083
81070117
China Postdoctoral Specialized Science Foundation201003700
Specialized Research Fund for the Doctoral Program of Higher Education20100181120090
Major Program of the Clinical High and New Technology of PLA2010gxjs039
Society of Cardiovascular Anesthesiologists (SCA)
Funding Information:

This study was supported by grants from the National Nature Science Foundation of China (81100180, 30801083 and 81070117), the China Postdoctoral Specialized Science Foundation (201003700), the Specialized Research Fund for the Doctoral Program of Higher Education (20100181120090), the Major Program of the Clinical High and New Technology of PLA (2010gxjs039) and The Society of Cardiovascular Anesthesiologists (SCA) research starter grant (2008 to Dr Xia).

 
dc.identifier.issn0014-2999
2012 Impact Factor: 2.592
2012 SCImago Journal Rankings: 0.832
 
dc.identifier.issue1-3
 
dc.identifier.pmid22222823
 
dc.identifier.scopuseid_2-s2.0-84856284379
 
dc.identifier.spage138
 
dc.identifier.urihttp://hdl.handle.net/10722/147288
 
dc.identifier.volume677
 
dc.languageeng
 
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejphar
 
dc.publisher.placeNetherlands
 
dc.relation.ispartofEuropean Journal of Pharmacology
 
dc.relation.referencesReferences in Scopus
 
dc.subjectCardiopulmonary Bypass
 
dc.subjectIschemia/Reperfusion Injury
 
dc.subjectIsoflurane
 
dc.subjectOxidative Stress
 
dc.subjectPropofol
 
dc.titleAlternative use of isoflurane and propofol confers superior cardioprotection than using one of them alone in a dog model of cardiopulmonary bypass
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong
  2. General Hospital of Chengdu Military Command
  3. Sichuan University