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Article: The effect of isoflurane or propofol anaesthesia on liver injury after partial hepatectomy in cirrhotic patients

TitleThe effect of isoflurane or propofol anaesthesia on liver injury after partial hepatectomy in cirrhotic patients
Authors
Issue Date2010
PublisherWiley-Blackwell Publishing Ltd.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0003-2409
Citation
Anaesthesia, 2010, v. 65 n. 11, p. 1094-1100 How to Cite?
AbstractThis study compared the effect of isoflurane or propofol anaesthesia on postoperative hepatocellular injury, liver function and pro-inflammatory cytokine concentrations in 60 cirrhotic patients, after partial hepatectomy using Pringle's manoeuvre. In the isoflurane group postoperatively, both mean (SD) aspartate aminotransferase (day 1: 197 (123) U.l -1 vs 261 (143) U.l -1; p = 0.01; day 3: 465 (258) U.l -1 vs 578 (311) U.l -1; p = 0.02) and alanine aminotransferase (day 1: 575 (312) U.l -1 vs 714 (434) U.l -1; p = 0.04 and day 3: 776 (443) U.l -1 vs 898 (746) U.l -1; p = 0.03) were significantly lower compared with the propofol group. Mean (SD) postoperative white cell count was significantly lower with isoflurane than propofol (day 1: 12 (4) × 10 3.mm -1 vs 16 (4) × 10 3.mm -1; p = 0.01 and day 3: 10 (6) × 10 3.mm -1; vs 14 (4); p = 0.01). Tumour necrosis factor-α (day 1) and interleukin-1 (days 1 and 3) concentrations were significantly lower with isoflurane. Compared with propofol, isoflurane is associated with an attenuated postoperative inflammatory response and less postoperative hepatocellular injury in patients having this procedure. © 2010 The Association of Anaesthetists of Great Britain and Ireland.
Persistent Identifierhttp://hdl.handle.net/10722/147277
ISSN
2015 Impact Factor: 3.794
2015 SCImago Journal Rankings: 1.404
ISI Accession Number ID
Funding AgencyGrant Number
Shanghai Rising-Star Program08QA14007
Funding Information:

This trial was funded by Shanghai Rising-Star Program (No 08QA14007). We would like to acknowledge the professional assistance provided by Dr Ng KF, Associate Professor, Department of Anaesthesiology, the University of Hong Kong, in reviewing and editing the English grammar in this manuscript. No competing interests declared.

References

 

DC FieldValueLanguage
dc.contributor.authorYang, LQen_US
dc.contributor.authorTao, KMen_US
dc.contributor.authorCheung, CWen_US
dc.contributor.authorLiu, YTen_US
dc.contributor.authorTao, Yen_US
dc.contributor.authorWu, FXen_US
dc.contributor.authorYu, WFen_US
dc.date.accessioned2012-05-29T06:01:11Z-
dc.date.available2012-05-29T06:01:11Z-
dc.date.issued2010en_US
dc.identifier.citationAnaesthesia, 2010, v. 65 n. 11, p. 1094-1100en_US
dc.identifier.issn0003-2409en_US
dc.identifier.urihttp://hdl.handle.net/10722/147277-
dc.description.abstractThis study compared the effect of isoflurane or propofol anaesthesia on postoperative hepatocellular injury, liver function and pro-inflammatory cytokine concentrations in 60 cirrhotic patients, after partial hepatectomy using Pringle's manoeuvre. In the isoflurane group postoperatively, both mean (SD) aspartate aminotransferase (day 1: 197 (123) U.l -1 vs 261 (143) U.l -1; p = 0.01; day 3: 465 (258) U.l -1 vs 578 (311) U.l -1; p = 0.02) and alanine aminotransferase (day 1: 575 (312) U.l -1 vs 714 (434) U.l -1; p = 0.04 and day 3: 776 (443) U.l -1 vs 898 (746) U.l -1; p = 0.03) were significantly lower compared with the propofol group. Mean (SD) postoperative white cell count was significantly lower with isoflurane than propofol (day 1: 12 (4) × 10 3.mm -1 vs 16 (4) × 10 3.mm -1; p = 0.01 and day 3: 10 (6) × 10 3.mm -1; vs 14 (4); p = 0.01). Tumour necrosis factor-α (day 1) and interleukin-1 (days 1 and 3) concentrations were significantly lower with isoflurane. Compared with propofol, isoflurane is associated with an attenuated postoperative inflammatory response and less postoperative hepatocellular injury in patients having this procedure. © 2010 The Association of Anaesthetists of Great Britain and Ireland.en_US
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing Ltd.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0003-2409en_US
dc.relation.ispartofAnaesthesiaen_US
dc.titleThe effect of isoflurane or propofol anaesthesia on liver injury after partial hepatectomy in cirrhotic patientsen_US
dc.typeArticleen_US
dc.identifier.emailCheung, CW:cheucw@hku.hken_US
dc.identifier.authorityCheung, CW=rp00244en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1365-2044.2010.06505.xen_US
dc.identifier.scopuseid_2-s2.0-78349265024en_US
dc.identifier.hkuros183246-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-78349265024&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume65en_US
dc.identifier.issue11en_US
dc.identifier.spage1094en_US
dc.identifier.epage1100en_US
dc.identifier.isiWOS:000282876500007-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.citeulike8032997-

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