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Article: Change in plasma free 15 - F2t - isoprostane concentrations in smoking patients undergoing coronary artery bypass grafting and its clinical significance

TitleChange in plasma free 15 - F2t - isoprostane concentrations in smoking patients undergoing coronary artery bypass grafting and its clinical significance
Authors
Issue Date2005
Citation
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue = Chinese Critical Care Medicine = Zhongguo Weizhongbing Jijiuyixue, 2005, v. 17 n. 3, p. 165-167 How to Cite?
AbstractOBJECTIVE: To investigate the change in plasma free 15-F2t-isoprostane fn(15-F(2t)-IsoP) concentration and its relationship with postoperative cardiac function of smoking patients who underwent coronary artery bypass grafting (CABG).METHODS: Sixty patients with coronary artery heart disease were divided into smoking group [n=30, age 54-69 years old, American Heart Association (AHA)II-III] and non-smoking group(n=30, age 58-70 years old, ASA II-III). All the patients were scheduled for CABG under combination anesthesia with isoflurane and fentanyl and conventional cardiopulmonary bypass. Blood samples were drawn from the central vein to measure 15-F(2t)-IsoP at the following time points: before operation (T0); 30 minutes after aortic clamping for cardiopulmonary bypass(T1); 10 and 30 minutes after aortic declamping(T2,T3). RESULTS: There was no statistical difference in 15-F(2t)-IsoP between two groups at T0, but contents of 15-F(2t)-IsoP in the two groups was increased markedly at T1, compared to those at T0 (P<0.05 and P<0.01 for smoking and non-smoking groups, respectively), and the degree of increase of 15-F(2t)-IsoP in smoking group was significantly higher than that in non-smoking group(P<0.05). During reperfusion period (at T2,T3), the rate of lowering of 15-F(2t)-IsoP in smoking group was slower than that in non-smoking group(P<0.05), and moreover, these patients needed more inotropic support than those in non-smoking group.CONCLUSION: Smoking patients have weaker anti-oxidation capability during CABG, therefore they have higher incidence of low cardiac function.
Persistent Identifierhttp://hdl.handle.net/10722/147270
ISSN
2015 SCImago Journal Rankings: 0.141

 

DC FieldValueLanguage
dc.contributor.authorYao, Ben_US
dc.contributor.authorJiang, HYen_US
dc.contributor.authorXia, ZYen_US
dc.contributor.authorHuang, ZYen_US
dc.date.accessioned2012-05-29T06:01:08Z-
dc.date.available2012-05-29T06:01:08Z-
dc.date.issued2005en_US
dc.identifier.citationZhongguo Wei Zhong Bing Ji Jiu Yi Xue = Chinese Critical Care Medicine = Zhongguo Weizhongbing Jijiuyixue, 2005, v. 17 n. 3, p. 165-167en_US
dc.identifier.issn1003-0603en_US
dc.identifier.urihttp://hdl.handle.net/10722/147270-
dc.description.abstractOBJECTIVE: To investigate the change in plasma free 15-F2t-isoprostane fn(15-F(2t)-IsoP) concentration and its relationship with postoperative cardiac function of smoking patients who underwent coronary artery bypass grafting (CABG).METHODS: Sixty patients with coronary artery heart disease were divided into smoking group [n=30, age 54-69 years old, American Heart Association (AHA)II-III] and non-smoking group(n=30, age 58-70 years old, ASA II-III). All the patients were scheduled for CABG under combination anesthesia with isoflurane and fentanyl and conventional cardiopulmonary bypass. Blood samples were drawn from the central vein to measure 15-F(2t)-IsoP at the following time points: before operation (T0); 30 minutes after aortic clamping for cardiopulmonary bypass(T1); 10 and 30 minutes after aortic declamping(T2,T3). RESULTS: There was no statistical difference in 15-F(2t)-IsoP between two groups at T0, but contents of 15-F(2t)-IsoP in the two groups was increased markedly at T1, compared to those at T0 (P<0.05 and P<0.01 for smoking and non-smoking groups, respectively), and the degree of increase of 15-F(2t)-IsoP in smoking group was significantly higher than that in non-smoking group(P<0.05). During reperfusion period (at T2,T3), the rate of lowering of 15-F(2t)-IsoP in smoking group was slower than that in non-smoking group(P<0.05), and moreover, these patients needed more inotropic support than those in non-smoking group.CONCLUSION: Smoking patients have weaker anti-oxidation capability during CABG, therefore they have higher incidence of low cardiac function.en_US
dc.languageengen_US
dc.relation.ispartofZhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixueen_US
dc.subject.meshAgeden_US
dc.subject.meshCoronary Artery Bypassen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshIntraoperative Perioden_US
dc.subject.meshIsoprostanes - Blooden_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshSmoking - Adverse Effectsen_US
dc.titleChange in plasma free 15 - F2t - isoprostane concentrations in smoking patients undergoing coronary artery bypass grafting and its clinical significanceen_US
dc.typeArticleen_US
dc.identifier.emailXia, ZY:zyxia@hkucc.hku.hken_US
dc.identifier.authorityXia, ZY=rp00532en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid15760530en_US
dc.identifier.scopuseid_2-s2.0-70349780162en_US
dc.identifier.volume17en_US
dc.identifier.issue3en_US
dc.identifier.spage165en_US
dc.identifier.epage167en_US

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