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Article: Clinical significance of plasma free 15-F2t-isoprostane concentration during coronary artery bypasses graft surgery

TitleClinical significance of plasma free 15-F2t-isoprostane concentration during coronary artery bypasses graft surgery
Authors
Issue Date2004
Citation
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue = Chinese Critical Care Medicine = Zhongguo Weizhongbing Jijiuyixue, 2004, v. 16 n. 3, p. 165-168 How to Cite?
AbstractOBJECTIVE: To analyse retrospectively the variation of plasma 15-F2t-isoprostane concentration during cardiac surgery and the relation with early myocardial dysfunction following normothemic cardiac surgery. METHODS: Thirty patients scheduled for coronary artery bypass graft surgery using normothermic cardiopulmonary bypass (CPB) and warm intermittent blood, crystalloid cardioplegia were enrolled. Patients were divided into two groups treated with (group II) or without (group I) positive inotropic drugs. Central venous blood was sampled at baseline, 30 minutes after global myocardial ischemia, 10, 30 and 120 minutes after aortic declamping (reperfusion). Plasma free 15-F2t-isoprostane was measured with enzyme immunoassay (EIA) using a highly specific rabbit 15-F2t-isoprostane antibody. Cardiac index (CI) was monitored intraoperatively and up to 6 hours following surgery. RESULTS: Plasma free 15-F2t-isoprostane increased significantly during ischemia, remained elevating at 10 minutes after reperfusion (P<0.05 vs. baseline) and began to decline at 30 minutes after reperfusion in the whole population. 15-F2t-isoprostane underwent exponential decay and returned to baseline at 30 minutes after reperfusion in group I that did not need any postoperative inotropic support. In contrast, 15-F2t-isoprostane further increased upon reperfusion and remained significantly higher than baseline at 30 minutes after reperfusion (P<0.05) in group II that needed two or more inotropes to maintain CI greater than 2.2 L x min(-1) x m(-2). Postoperative CI was significantly inversely correlated with the percentage change in plasma free 15-F2t-isoprostane concentration from 10 to 30 minutes after reperfusion (r=-0.95, P<0.01). CONCLUSION: It shows a close relationship between free plasma concentrations of 15-F2t-isoprostane and early postoperative cardiac function following coronary artery bypass graft surgery.
Persistent Identifierhttp://hdl.handle.net/10722/147256
ISSN
2015 SCImago Journal Rankings: 0.141

 

DC FieldValueLanguage
dc.contributor.authorHuang, ZYen_US
dc.contributor.authorXia, ZYen_US
dc.contributor.authorAnsley, DMen_US
dc.contributor.authorDhaliwal, BSen_US
dc.date.accessioned2012-05-29T06:01:04Z-
dc.date.available2012-05-29T06:01:04Z-
dc.date.issued2004en_US
dc.identifier.citationZhongguo Wei Zhong Bing Ji Jiu Yi Xue = Chinese Critical Care Medicine = Zhongguo Weizhongbing Jijiuyixue, 2004, v. 16 n. 3, p. 165-168en_US
dc.identifier.issn1003-0603en_US
dc.identifier.urihttp://hdl.handle.net/10722/147256-
dc.description.abstractOBJECTIVE: To analyse retrospectively the variation of plasma 15-F2t-isoprostane concentration during cardiac surgery and the relation with early myocardial dysfunction following normothemic cardiac surgery. METHODS: Thirty patients scheduled for coronary artery bypass graft surgery using normothermic cardiopulmonary bypass (CPB) and warm intermittent blood, crystalloid cardioplegia were enrolled. Patients were divided into two groups treated with (group II) or without (group I) positive inotropic drugs. Central venous blood was sampled at baseline, 30 minutes after global myocardial ischemia, 10, 30 and 120 minutes after aortic declamping (reperfusion). Plasma free 15-F2t-isoprostane was measured with enzyme immunoassay (EIA) using a highly specific rabbit 15-F2t-isoprostane antibody. Cardiac index (CI) was monitored intraoperatively and up to 6 hours following surgery. RESULTS: Plasma free 15-F2t-isoprostane increased significantly during ischemia, remained elevating at 10 minutes after reperfusion (P<0.05 vs. baseline) and began to decline at 30 minutes after reperfusion in the whole population. 15-F2t-isoprostane underwent exponential decay and returned to baseline at 30 minutes after reperfusion in group I that did not need any postoperative inotropic support. In contrast, 15-F2t-isoprostane further increased upon reperfusion and remained significantly higher than baseline at 30 minutes after reperfusion (P<0.05) in group II that needed two or more inotropes to maintain CI greater than 2.2 L x min(-1) x m(-2). Postoperative CI was significantly inversely correlated with the percentage change in plasma free 15-F2t-isoprostane concentration from 10 to 30 minutes after reperfusion (r=-0.95, P<0.01). CONCLUSION: It shows a close relationship between free plasma concentrations of 15-F2t-isoprostane and early postoperative cardiac function following coronary artery bypass graft surgery.en_US
dc.languageengen_US
dc.relation.ispartofZhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixueen_US
dc.subject.meshAgeden_US
dc.subject.meshCoronary Artery Bypassen_US
dc.subject.meshDinoprost - Analogs & Derivatives - Blooden_US
dc.subject.meshEnzyme-Linked Immunosorbent Assayen_US
dc.subject.meshFemaleen_US
dc.subject.meshHeart - Physiopathologyen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPostoperative Careen_US
dc.subject.meshPrognosisen_US
dc.subject.meshRetrospective Studiesen_US
dc.titleClinical significance of plasma free 15-F2t-isoprostane concentration during coronary artery bypasses graft surgeryen_US
dc.typeArticleen_US
dc.identifier.emailXia, ZY:zyxia@hkucc.hku.hken_US
dc.identifier.authorityXia, ZY=rp00532en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid15009967-
dc.identifier.scopuseid_2-s2.0-4644269663en_US
dc.identifier.volume16en_US
dc.identifier.issue3en_US
dc.identifier.spage165en_US
dc.identifier.epage168en_US

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