File Download
  • No File Attached
 
Links for fulltext
(May Require Subscription)
 
Supplementary

Article: Clinical significance of plasma free 15-F2t-isoprostane concentration during coronary artery bypasses graft surgery
  • Basic View
  • Metadata View
  • XML View
TitleClinical significance of plasma free 15-F2t-isoprostane concentration during coronary artery bypasses graft surgery
 
AuthorsHuang, ZY1
Xia, ZY1
Ansley, DM1
Dhaliwal, BS1
 
Issue Date2004
 
CitationZhongguo Wei Zhong Bing Ji Jiu Yi Xue = Chinese Critical Care Medicine = Zhongguo Weizhongbing Jijiuyixue, 2004, v. 16 n. 3, p. 165-168 [How to Cite?]
 
AbstractOBJECTIVE: To analyse retrospectively the variation of plasma 15-F2t-isoprostane concentration during cardiac surgery and the relation with early myocardial dysfunction following normothemic cardiac surgery. METHODS: Thirty patients scheduled for coronary artery bypass graft surgery using normothermic cardiopulmonary bypass (CPB) and warm intermittent blood, crystalloid cardioplegia were enrolled. Patients were divided into two groups treated with (group II) or without (group I) positive inotropic drugs. Central venous blood was sampled at baseline, 30 minutes after global myocardial ischemia, 10, 30 and 120 minutes after aortic declamping (reperfusion). Plasma free 15-F2t-isoprostane was measured with enzyme immunoassay (EIA) using a highly specific rabbit 15-F2t-isoprostane antibody. Cardiac index (CI) was monitored intraoperatively and up to 6 hours following surgery. RESULTS: Plasma free 15-F2t-isoprostane increased significantly during ischemia, remained elevating at 10 minutes after reperfusion (P<0.05 vs. baseline) and began to decline at 30 minutes after reperfusion in the whole population. 15-F2t-isoprostane underwent exponential decay and returned to baseline at 30 minutes after reperfusion in group I that did not need any postoperative inotropic support. In contrast, 15-F2t-isoprostane further increased upon reperfusion and remained significantly higher than baseline at 30 minutes after reperfusion (P<0.05) in group II that needed two or more inotropes to maintain CI greater than 2.2 L x min(-1) x m(-2). Postoperative CI was significantly inversely correlated with the percentage change in plasma free 15-F2t-isoprostane concentration from 10 to 30 minutes after reperfusion (r=-0.95, P<0.01). CONCLUSION: It shows a close relationship between free plasma concentrations of 15-F2t-isoprostane and early postoperative cardiac function following coronary artery bypass graft surgery.
 
ISSN1003-0603
2013 SCImago Journal Rankings: 0.135
 
DC FieldValue
dc.contributor.authorHuang, ZY
 
dc.contributor.authorXia, ZY
 
dc.contributor.authorAnsley, DM
 
dc.contributor.authorDhaliwal, BS
 
dc.date.accessioned2012-05-29T06:01:04Z
 
dc.date.available2012-05-29T06:01:04Z
 
dc.date.issued2004
 
dc.description.abstractOBJECTIVE: To analyse retrospectively the variation of plasma 15-F2t-isoprostane concentration during cardiac surgery and the relation with early myocardial dysfunction following normothemic cardiac surgery. METHODS: Thirty patients scheduled for coronary artery bypass graft surgery using normothermic cardiopulmonary bypass (CPB) and warm intermittent blood, crystalloid cardioplegia were enrolled. Patients were divided into two groups treated with (group II) or without (group I) positive inotropic drugs. Central venous blood was sampled at baseline, 30 minutes after global myocardial ischemia, 10, 30 and 120 minutes after aortic declamping (reperfusion). Plasma free 15-F2t-isoprostane was measured with enzyme immunoassay (EIA) using a highly specific rabbit 15-F2t-isoprostane antibody. Cardiac index (CI) was monitored intraoperatively and up to 6 hours following surgery. RESULTS: Plasma free 15-F2t-isoprostane increased significantly during ischemia, remained elevating at 10 minutes after reperfusion (P<0.05 vs. baseline) and began to decline at 30 minutes after reperfusion in the whole population. 15-F2t-isoprostane underwent exponential decay and returned to baseline at 30 minutes after reperfusion in group I that did not need any postoperative inotropic support. In contrast, 15-F2t-isoprostane further increased upon reperfusion and remained significantly higher than baseline at 30 minutes after reperfusion (P<0.05) in group II that needed two or more inotropes to maintain CI greater than 2.2 L x min(-1) x m(-2). Postoperative CI was significantly inversely correlated with the percentage change in plasma free 15-F2t-isoprostane concentration from 10 to 30 minutes after reperfusion (r=-0.95, P<0.01). CONCLUSION: It shows a close relationship between free plasma concentrations of 15-F2t-isoprostane and early postoperative cardiac function following coronary artery bypass graft surgery.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationZhongguo Wei Zhong Bing Ji Jiu Yi Xue = Chinese Critical Care Medicine = Zhongguo Weizhongbing Jijiuyixue, 2004, v. 16 n. 3, p. 165-168 [How to Cite?]
 
dc.identifier.epage168
 
dc.identifier.issn1003-0603
2013 SCImago Journal Rankings: 0.135
 
dc.identifier.issue3
 
dc.identifier.pmid15009967
 
dc.identifier.scopuseid_2-s2.0-4644269663
 
dc.identifier.spage165
 
dc.identifier.urihttp://hdl.handle.net/10722/147256
 
dc.identifier.volume16
 
dc.languageeng
 
dc.relation.ispartofZhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue
 
dc.subject.meshAged
 
dc.subject.meshCoronary Artery Bypass
 
dc.subject.meshDinoprost - Analogs & Derivatives - Blood
 
dc.subject.meshEnzyme-Linked Immunosorbent Assay
 
dc.subject.meshFemale
 
dc.subject.meshHeart - Physiopathology
 
dc.subject.meshHumans
 
dc.subject.meshMale
 
dc.subject.meshMiddle Aged
 
dc.subject.meshPostoperative Care
 
dc.subject.meshPrognosis
 
dc.subject.meshRetrospective Studies
 
dc.titleClinical significance of plasma free 15-F2t-isoprostane concentration during coronary artery bypasses graft surgery
 
dc.typeArticle
 
<?xml encoding="utf-8" version="1.0"?>
<item><contributor.author>Huang, ZY</contributor.author>
<contributor.author>Xia, ZY</contributor.author>
<contributor.author>Ansley, DM</contributor.author>
<contributor.author>Dhaliwal, BS</contributor.author>
<date.accessioned>2012-05-29T06:01:04Z</date.accessioned>
<date.available>2012-05-29T06:01:04Z</date.available>
<date.issued>2004</date.issued>
<identifier.citation>Zhongguo Wei Zhong Bing Ji Jiu Yi Xue = Chinese Critical Care Medicine = Zhongguo Weizhongbing Jijiuyixue, 2004, v. 16 n. 3, p. 165-168</identifier.citation>
<identifier.issn>1003-0603</identifier.issn>
<identifier.uri>http://hdl.handle.net/10722/147256</identifier.uri>
<description.abstract>OBJECTIVE: To analyse retrospectively the variation of plasma 15-F2t-isoprostane concentration during cardiac surgery and the relation with early myocardial dysfunction following normothemic cardiac surgery. METHODS: Thirty patients scheduled for coronary artery bypass graft surgery using normothermic cardiopulmonary bypass (CPB) and warm intermittent blood, crystalloid cardioplegia were enrolled. Patients were divided into two groups treated with (group II) or without (group I) positive inotropic drugs. Central venous blood was sampled at baseline, 30 minutes after global myocardial ischemia, 10, 30 and 120 minutes after aortic declamping (reperfusion). Plasma free 15-F2t-isoprostane was measured with enzyme immunoassay (EIA) using a highly specific rabbit 15-F2t-isoprostane antibody. Cardiac index (CI) was monitored intraoperatively and up to 6 hours following surgery. RESULTS: Plasma free 15-F2t-isoprostane increased significantly during ischemia, remained elevating at 10 minutes after reperfusion (P&lt;0.05 vs. baseline) and began to decline at 30 minutes after reperfusion in the whole population. 15-F2t-isoprostane underwent exponential decay and returned to baseline at 30 minutes after reperfusion in group I that did not need any postoperative inotropic support. In contrast, 15-F2t-isoprostane further increased upon reperfusion and remained significantly higher than baseline at 30 minutes after reperfusion (P&lt;0.05) in group II that needed two or more inotropes to maintain CI greater than 2.2 L x min(-1) x m(-2). Postoperative CI was significantly inversely correlated with the percentage change in plasma free 15-F2t-isoprostane concentration from 10 to 30 minutes after reperfusion (r=-0.95, P&lt;0.01). CONCLUSION: It shows a close relationship between free plasma concentrations of 15-F2t-isoprostane and early postoperative cardiac function following coronary artery bypass graft surgery.</description.abstract>
<language>eng</language>
<relation.ispartof>Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue</relation.ispartof>
<subject.mesh>Aged</subject.mesh>
<subject.mesh>Coronary Artery Bypass</subject.mesh>
<subject.mesh>Dinoprost - Analogs &amp; Derivatives - Blood</subject.mesh>
<subject.mesh>Enzyme-Linked Immunosorbent Assay</subject.mesh>
<subject.mesh>Female</subject.mesh>
<subject.mesh>Heart - Physiopathology</subject.mesh>
<subject.mesh>Humans</subject.mesh>
<subject.mesh>Male</subject.mesh>
<subject.mesh>Middle Aged</subject.mesh>
<subject.mesh>Postoperative Care</subject.mesh>
<subject.mesh>Prognosis</subject.mesh>
<subject.mesh>Retrospective Studies</subject.mesh>
<title>Clinical significance of plasma free 15-F2t-isoprostane concentration during coronary artery bypasses graft surgery</title>
<type>Article</type>
<description.nature>link_to_subscribed_fulltext</description.nature>
<identifier.pmid>15009967</identifier.pmid>
<identifier.scopus>eid_2-s2.0-4644269663</identifier.scopus>
<identifier.volume>16</identifier.volume>
<identifier.issue>3</identifier.issue>
<identifier.spage>165</identifier.spage>
<identifier.epage>168</identifier.epage>
</item>
Author Affiliations
  1. Shenzhen Sun Yat-Sen Cardiovascular Hospital