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Article: Systemic ischemic preconditioning plus hemodilution enhanced early functional recovery of reperfused heart in the rabbits

TitleSystemic ischemic preconditioning plus hemodilution enhanced early functional recovery of reperfused heart in the rabbits
Authors
KeywordsHemodilution
Myocardial Ischemia
Rabbits
Reperfusion
Systemic Ischemic Preconditioning
Issue Date2004
PublisherElsevier BV. The Journal's web site is located at http://intl-icvts.ctsnetjournals.org
Citation
Interactive Cardiovascular And Thoracic Surgery, 2004, v. 3 n. 3, p. 528-532 How to Cite?
AbstractWe investigated whether transient systemic ischemia can precondition the heart against the ensuing ischemic insult. Rabbits were randomly divided into systemic ischemic preconditioning (SIP), hemodilution (HD) and control (C) groups. SIP was induced by rapidly withdrawing blood from femoral artery and maintaining the mean artery pressure at 50 mmHg for 10 min. Afterwards, 50% of the withdrawn blood was re-infused with equal volumes of 6% deferoxamine- conjugated hydroxyethyl-starch (D-HES). Hemodilution in HD group was achieved by withdrawing blood at 8 ml/kg accompanied by concomitant infusion of equal volumes of D-HES. Animals were subjected to 30 min of coronary artery occlusion followed by 120 min of reperfusion. Cardiac output (CO) (thermodilution method), plasma malondialdehyde and nitric oxide content were measured at baseline and until 120 (R 120) min of reperfusion. At R 120, CO in group-C was significantly lower than its baseline value, accompanied by a significant reduction in nitric oxide production and increase in malondialdehyde concentration; CO in group-SIP and group-HD maintained at baseline levels throughout reperfusion. At R 120, CO in group-SIP, but not in group-HD, was significantly higher than that in group-C. It is concluded that transient SIP followed by hemodilution with D-HES facilitates early functional recovery of the ischemic-reperfused rabbit hearts. © 2004 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/147253
ISSN
2015 Impact Factor: 1.329
2015 SCImago Journal Rankings: 0.743
References

 

DC FieldValueLanguage
dc.contributor.authorXia, Zen_US
dc.contributor.authorXia, Ren_US
dc.contributor.authorLan, HTen_US
dc.contributor.authorLuo, Ten_US
dc.contributor.authorTang, QZen_US
dc.contributor.authorXia, ZYen_US
dc.contributor.authorLiu, XYen_US
dc.date.accessioned2012-05-29T06:01:03Z-
dc.date.available2012-05-29T06:01:03Z-
dc.date.issued2004en_US
dc.identifier.citationInteractive Cardiovascular And Thoracic Surgery, 2004, v. 3 n. 3, p. 528-532en_US
dc.identifier.issn1569-9293en_US
dc.identifier.urihttp://hdl.handle.net/10722/147253-
dc.description.abstractWe investigated whether transient systemic ischemia can precondition the heart against the ensuing ischemic insult. Rabbits were randomly divided into systemic ischemic preconditioning (SIP), hemodilution (HD) and control (C) groups. SIP was induced by rapidly withdrawing blood from femoral artery and maintaining the mean artery pressure at 50 mmHg for 10 min. Afterwards, 50% of the withdrawn blood was re-infused with equal volumes of 6% deferoxamine- conjugated hydroxyethyl-starch (D-HES). Hemodilution in HD group was achieved by withdrawing blood at 8 ml/kg accompanied by concomitant infusion of equal volumes of D-HES. Animals were subjected to 30 min of coronary artery occlusion followed by 120 min of reperfusion. Cardiac output (CO) (thermodilution method), plasma malondialdehyde and nitric oxide content were measured at baseline and until 120 (R 120) min of reperfusion. At R 120, CO in group-C was significantly lower than its baseline value, accompanied by a significant reduction in nitric oxide production and increase in malondialdehyde concentration; CO in group-SIP and group-HD maintained at baseline levels throughout reperfusion. At R 120, CO in group-SIP, but not in group-HD, was significantly higher than that in group-C. It is concluded that transient SIP followed by hemodilution with D-HES facilitates early functional recovery of the ischemic-reperfused rabbit hearts. © 2004 Elsevier B.V. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://intl-icvts.ctsnetjournals.orgen_US
dc.relation.ispartofInteractive Cardiovascular and Thoracic Surgeryen_US
dc.subjectHemodilutionen_US
dc.subjectMyocardial Ischemiaen_US
dc.subjectRabbitsen_US
dc.subjectReperfusionen_US
dc.subjectSystemic Ischemic Preconditioningen_US
dc.titleSystemic ischemic preconditioning plus hemodilution enhanced early functional recovery of reperfused heart in the rabbitsen_US
dc.typeArticleen_US
dc.identifier.emailXia, Z:zyxia@hkucc.hku.hken_US
dc.identifier.authorityXia, Z=rp00532en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.icvts.2004.05.007en_US
dc.identifier.scopuseid_2-s2.0-4143143069en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-4143143069&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume3en_US
dc.identifier.issue3en_US
dc.identifier.spage528en_US
dc.identifier.epage532en_US
dc.publisher.placeNetherlandsen_US

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