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Article: The effect of sevoflurane on cerebral autoregulation in young children as assessed by the transient hyperemic response

TitleThe effect of sevoflurane on cerebral autoregulation in young children as assessed by the transient hyperemic response
Authors
Issue Date2006
PublisherLippincott, Williams & Wilkins. The Journal's web site is located at http://www.anesthesia-analgesia.org
Citation
Anesthesia And Analgesia, 2006, v. 102 n. 4, p. 1051-1055 How to Cite?
AbstractThe transient hyperemic response (THR) test is a simple, noninvasive technique to evaluate cerebral autoregulation using transcranial Doppler. It has not yet been used in studies involving children. In this study we evaluated this response in children undergoing general anesthesia using sevoflurane. Twenty ASA physical status I children undergoing elective urological surgery sequentially received sevoflurane at 0.5, 1.0, and 1.5 MAC in a randomized order. Analgesia was solely provided by caudal anesthesia. The right middle cerebral artery flow velocities before (F1), during (F2), and after (F3) a 10-s ipsilateral carotid artery compression were recorded. The THR ratios (THRR) (± SD) for 0.5 MAC, 1.0 MAC, and 1.5 MAC were 1.24 ± 0.11, 1.16 ± 0.09, and 1.13 ± 0.07, respectively. The THRR was significantly different between 0.5 MAC versus 1.0 and 1.5 MAC, respectively (P < 0.05). However, no difference was detected between 1.0 and 1.5 MAC. A THRR of more than 1.09 has previously been accepted as the lower limit of a positive response. The results in this study suggest that THR is affected by sevoflurane in a dose-dependent fashion but is maintained at up to 1.5 MAC. This suggests cerebral autoregulation is preserved in children anesthetized with up to 1.5 MAC sevoflurane. ©2006 by the International Anesthesia Research Society.
Persistent Identifierhttp://hdl.handle.net/10722/147229
ISSN
2015 Impact Factor: 3.827
2015 SCImago Journal Rankings: 1.523
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, GTen_US
dc.contributor.authorLuginbuehl, Ien_US
dc.contributor.authorKarsli, Cen_US
dc.contributor.authorBissonnette, Ben_US
dc.date.accessioned2012-05-29T06:00:55Z-
dc.date.available2012-05-29T06:00:55Z-
dc.date.issued2006en_US
dc.identifier.citationAnesthesia And Analgesia, 2006, v. 102 n. 4, p. 1051-1055en_US
dc.identifier.issn0003-2999en_US
dc.identifier.urihttp://hdl.handle.net/10722/147229-
dc.description.abstractThe transient hyperemic response (THR) test is a simple, noninvasive technique to evaluate cerebral autoregulation using transcranial Doppler. It has not yet been used in studies involving children. In this study we evaluated this response in children undergoing general anesthesia using sevoflurane. Twenty ASA physical status I children undergoing elective urological surgery sequentially received sevoflurane at 0.5, 1.0, and 1.5 MAC in a randomized order. Analgesia was solely provided by caudal anesthesia. The right middle cerebral artery flow velocities before (F1), during (F2), and after (F3) a 10-s ipsilateral carotid artery compression were recorded. The THR ratios (THRR) (± SD) for 0.5 MAC, 1.0 MAC, and 1.5 MAC were 1.24 ± 0.11, 1.16 ± 0.09, and 1.13 ± 0.07, respectively. The THRR was significantly different between 0.5 MAC versus 1.0 and 1.5 MAC, respectively (P < 0.05). However, no difference was detected between 1.0 and 1.5 MAC. A THRR of more than 1.09 has previously been accepted as the lower limit of a positive response. The results in this study suggest that THR is affected by sevoflurane in a dose-dependent fashion but is maintained at up to 1.5 MAC. This suggests cerebral autoregulation is preserved in children anesthetized with up to 1.5 MAC sevoflurane. ©2006 by the International Anesthesia Research Society.en_US
dc.languageengen_US
dc.publisherLippincott, Williams & Wilkins. The Journal's web site is located at http://www.anesthesia-analgesia.orgen_US
dc.relation.ispartofAnesthesia and Analgesiaen_US
dc.subject.meshAnesthesia, Inhalation - Methodsen_US
dc.subject.meshBlood Flow Velocity - Drug Effects - Physiologyen_US
dc.subject.meshBrain - Blood Supply - Drug Effectsen_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshHomeostasis - Drug Effects - Physiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshHyperemia - Physiopathologyen_US
dc.subject.meshInfanten_US
dc.subject.meshMethyl Ethers - Pharmacologyen_US
dc.subject.meshUltrasonography, Doppler, Transcranial - Methodsen_US
dc.titleThe effect of sevoflurane on cerebral autoregulation in young children as assessed by the transient hyperemic responseen_US
dc.typeArticleen_US
dc.identifier.emailWong, GT:gordon@hku.hken_US
dc.identifier.authorityWong, GT=rp00523en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1213/01.ane.0000198562.99761.0een_US
dc.identifier.pmid16551897en_US
dc.identifier.scopuseid_2-s2.0-33645522173en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33645522173&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume102en_US
dc.identifier.issue4en_US
dc.identifier.spage1051en_US
dc.identifier.epage1055en_US
dc.identifier.isiWOS:000236371100013-
dc.publisher.placeUnited Statesen_US

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