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- Publisher Website: 10.1213/01.ane.0000198562.99761.0e
- Scopus: eid_2-s2.0-33645522173
- PMID: 16551897
- WOS: WOS:000236371100013
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Article: The effect of sevoflurane on cerebral autoregulation in young children as assessed by the transient hyperemic response
Title | The effect of sevoflurane on cerebral autoregulation in young children as assessed by the transient hyperemic response |
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Authors | |
Issue Date | 2006 |
Publisher | Lippincott, Williams & Wilkins. The Journal's web site is located at http://www.anesthesia-analgesia.org |
Citation | Anesthesia And Analgesia, 2006, v. 102 n. 4, p. 1051-1055 How to Cite? |
Abstract | The transient hyperemic response (THR) test is a simple, noninvasive technique to evaluate cerebral autoregulation using transcranial Doppler. It has not yet been used in studies involving children. In this study we evaluated this response in children undergoing general anesthesia using sevoflurane. Twenty ASA physical status I children undergoing elective urological surgery sequentially received sevoflurane at 0.5, 1.0, and 1.5 MAC in a randomized order. Analgesia was solely provided by caudal anesthesia. The right middle cerebral artery flow velocities before (F1), during (F2), and after (F3) a 10-s ipsilateral carotid artery compression were recorded. The THR ratios (THRR) (± SD) for 0.5 MAC, 1.0 MAC, and 1.5 MAC were 1.24 ± 0.11, 1.16 ± 0.09, and 1.13 ± 0.07, respectively. The THRR was significantly different between 0.5 MAC versus 1.0 and 1.5 MAC, respectively (P < 0.05). However, no difference was detected between 1.0 and 1.5 MAC. A THRR of more than 1.09 has previously been accepted as the lower limit of a positive response. The results in this study suggest that THR is affected by sevoflurane in a dose-dependent fashion but is maintained at up to 1.5 MAC. This suggests cerebral autoregulation is preserved in children anesthetized with up to 1.5 MAC sevoflurane. ©2006 by the International Anesthesia Research Society. |
Persistent Identifier | http://hdl.handle.net/10722/147229 |
ISSN | 2023 Impact Factor: 4.6 2023 SCImago Journal Rankings: 1.344 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Wong, GT | en_US |
dc.contributor.author | Luginbuehl, I | en_US |
dc.contributor.author | Karsli, C | en_US |
dc.contributor.author | Bissonnette, B | en_US |
dc.date.accessioned | 2012-05-29T06:00:55Z | - |
dc.date.available | 2012-05-29T06:00:55Z | - |
dc.date.issued | 2006 | en_US |
dc.identifier.citation | Anesthesia And Analgesia, 2006, v. 102 n. 4, p. 1051-1055 | en_US |
dc.identifier.issn | 0003-2999 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/147229 | - |
dc.description.abstract | The transient hyperemic response (THR) test is a simple, noninvasive technique to evaluate cerebral autoregulation using transcranial Doppler. It has not yet been used in studies involving children. In this study we evaluated this response in children undergoing general anesthesia using sevoflurane. Twenty ASA physical status I children undergoing elective urological surgery sequentially received sevoflurane at 0.5, 1.0, and 1.5 MAC in a randomized order. Analgesia was solely provided by caudal anesthesia. The right middle cerebral artery flow velocities before (F1), during (F2), and after (F3) a 10-s ipsilateral carotid artery compression were recorded. The THR ratios (THRR) (± SD) for 0.5 MAC, 1.0 MAC, and 1.5 MAC were 1.24 ± 0.11, 1.16 ± 0.09, and 1.13 ± 0.07, respectively. The THRR was significantly different between 0.5 MAC versus 1.0 and 1.5 MAC, respectively (P < 0.05). However, no difference was detected between 1.0 and 1.5 MAC. A THRR of more than 1.09 has previously been accepted as the lower limit of a positive response. The results in this study suggest that THR is affected by sevoflurane in a dose-dependent fashion but is maintained at up to 1.5 MAC. This suggests cerebral autoregulation is preserved in children anesthetized with up to 1.5 MAC sevoflurane. ©2006 by the International Anesthesia Research Society. | en_US |
dc.language | eng | en_US |
dc.publisher | Lippincott, Williams & Wilkins. The Journal's web site is located at http://www.anesthesia-analgesia.org | en_US |
dc.relation.ispartof | Anesthesia and Analgesia | en_US |
dc.subject.mesh | Anesthesia, Inhalation - Methods | en_US |
dc.subject.mesh | Blood Flow Velocity - Drug Effects - Physiology | en_US |
dc.subject.mesh | Brain - Blood Supply - Drug Effects | en_US |
dc.subject.mesh | Child, Preschool | en_US |
dc.subject.mesh | Homeostasis - Drug Effects - Physiology | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Hyperemia - Physiopathology | en_US |
dc.subject.mesh | Infant | en_US |
dc.subject.mesh | Methyl Ethers - Pharmacology | en_US |
dc.subject.mesh | Ultrasonography, Doppler, Transcranial - Methods | en_US |
dc.title | The effect of sevoflurane on cerebral autoregulation in young children as assessed by the transient hyperemic response | en_US |
dc.type | Article | en_US |
dc.identifier.email | Wong, GT:gordon@hku.hk | en_US |
dc.identifier.authority | Wong, GT=rp00523 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1213/01.ane.0000198562.99761.0e | en_US |
dc.identifier.pmid | 16551897 | en_US |
dc.identifier.scopus | eid_2-s2.0-33645522173 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-33645522173&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 102 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.spage | 1051 | en_US |
dc.identifier.epage | 1055 | en_US |
dc.identifier.isi | WOS:000236371100013 | - |
dc.publisher.place | United States | en_US |
dc.identifier.issnl | 0003-2999 | - |