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Article: Antioxidant N-acetylcysteine restores systemic nitric oxide availability and corrects depressions in arterial blood pressure and heart rate in diabetic rats

TitleAntioxidant N-acetylcysteine restores systemic nitric oxide availability and corrects depressions in arterial blood pressure and heart rate in diabetic rats
Authors
Issue Date2006
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/10715762.asp
Citation
Free Radical Research, 2006, v. 40 n. 2, p. 175-184 How to Cite?
AbstractIncreased oxidative stress and reduced nitric oxide (NO) bioactivity are key features of diabetes mellitus that eventually result in cardiovascular abnormalities. We assessed whether N-acetylcysteine (NAC), an antioxidant and glutathione precursor, could prevent the hyperglycaemia induced increase in oxidative stress, restore NO availability and prevent depression of arterial blood pressure and heart rate in vivo in experimental diabetes. Control (C) and streptozotocin-induced diabetic (D) rats were treated or not treated with NAC in drinking water for 8 weeks, initiated 1 week after induction of diabetes. At termination, plasma levels of free 15-F2t -isoprostane, a specific marker of oxygen free radical induced lipid peroxidation, was increased while the plasma total antioxidant concentration was decreased in untreated diabetic rats as compared to control rats (P < 0.05). This was accompanied by a significant reduction of plasma levels of nitrate and nitrite, stable metabolites of NO, (P < 0.05, D vs. C) and a reduced endothelial NO synthase protein expression in the heart and in aortic and mesenteric artery tissues. Systolic, diastolic and mean arterial blood pressures (SBP, DBP and MAP) and heart rate (HR) were reduced in diabetic rats (P < 0.05 vs. C) and NAC normalised the changes that occurred in the diabetic rats. The protective effects may be attributable to restoration of NO bioavailability in the circulation. © 2006 Taylor & Francis.
Persistent Identifierhttp://hdl.handle.net/10722/147223
ISSN
2015 Impact Factor: 2.949
2015 SCImago Journal Rankings: 1.159
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorXia, Zen_US
dc.contributor.authorNagareddy, PRen_US
dc.contributor.authorGuo, Zen_US
dc.contributor.authorZhang, Wen_US
dc.contributor.authorMcneill, JHen_US
dc.date.accessioned2012-05-29T06:00:53Z-
dc.date.available2012-05-29T06:00:53Z-
dc.date.issued2006en_US
dc.identifier.citationFree Radical Research, 2006, v. 40 n. 2, p. 175-184en_US
dc.identifier.issn1071-5762en_US
dc.identifier.urihttp://hdl.handle.net/10722/147223-
dc.description.abstractIncreased oxidative stress and reduced nitric oxide (NO) bioactivity are key features of diabetes mellitus that eventually result in cardiovascular abnormalities. We assessed whether N-acetylcysteine (NAC), an antioxidant and glutathione precursor, could prevent the hyperglycaemia induced increase in oxidative stress, restore NO availability and prevent depression of arterial blood pressure and heart rate in vivo in experimental diabetes. Control (C) and streptozotocin-induced diabetic (D) rats were treated or not treated with NAC in drinking water for 8 weeks, initiated 1 week after induction of diabetes. At termination, plasma levels of free 15-F2t -isoprostane, a specific marker of oxygen free radical induced lipid peroxidation, was increased while the plasma total antioxidant concentration was decreased in untreated diabetic rats as compared to control rats (P < 0.05). This was accompanied by a significant reduction of plasma levels of nitrate and nitrite, stable metabolites of NO, (P < 0.05, D vs. C) and a reduced endothelial NO synthase protein expression in the heart and in aortic and mesenteric artery tissues. Systolic, diastolic and mean arterial blood pressures (SBP, DBP and MAP) and heart rate (HR) were reduced in diabetic rats (P < 0.05 vs. C) and NAC normalised the changes that occurred in the diabetic rats. The protective effects may be attributable to restoration of NO bioavailability in the circulation. © 2006 Taylor & Francis.en_US
dc.languageengen_US
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/10715762.aspen_US
dc.relation.ispartofFree Radical Researchen_US
dc.subject.meshAcetylcysteine - Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntioxidants - Pharmacologyen_US
dc.subject.meshArteriesen_US
dc.subject.meshBlood Pressure - Drug Effectsen_US
dc.subject.meshDiabetes Mellitus, Experimental - Metabolism - Prevention & Controlen_US
dc.subject.meshDinoprost - Analogs & Derivatives - Blood - Metabolismen_US
dc.subject.meshFree Radicals - Metabolismen_US
dc.subject.meshHeart Rate - Drug Effectsen_US
dc.subject.meshLipid Peroxidationen_US
dc.subject.meshMaleen_US
dc.subject.meshNitrates - Blooden_US
dc.subject.meshNitric Oxide - Metabolismen_US
dc.subject.meshNitric Oxide Synthase Type Iii - Metabolismen_US
dc.subject.meshNitrites - Blooden_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.subject.meshStreptozocin - Toxicityen_US
dc.subject.meshVasoconstrictor Agents - Blooden_US
dc.titleAntioxidant N-acetylcysteine restores systemic nitric oxide availability and corrects depressions in arterial blood pressure and heart rate in diabetic ratsen_US
dc.typeArticleen_US
dc.identifier.emailXia, Z:zyxia@hkucc.hku.hken_US
dc.identifier.authorityXia, Z=rp00532en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1080/10715760500484336en_US
dc.identifier.pmid16390827en_US
dc.identifier.scopuseid_2-s2.0-30144438917en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-30144438917&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume40en_US
dc.identifier.issue2en_US
dc.identifier.spage175en_US
dc.identifier.epage184en_US
dc.identifier.isiWOS:000234385600009-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.citeulike453392-

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