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- Publisher Website: 10.1139/y04-097
- Scopus: eid_2-s2.0-13544258769
- PMID: 15573153
- WOS: WOS:000226483800014
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Article: Application of high-dose propofol during ischemia improves postischemic function of rat hearts: Effects on tissue antioxidant capacity
Title | Application of high-dose propofol during ischemia improves postischemic function of rat hearts: Effects on tissue antioxidant capacity |
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Authors | |
Keywords | Heart Ischemia Oxidative stress Propofol Rat |
Issue Date | 2004 |
Publisher | N R C Research Press. The Journal's web site is located at http://pubs.nrc-cnrc.gc.ca/cgi-bin/rp/rp2_desc_e?cjpp |
Citation | Canadian Journal Of Physiology And Pharmacology, 2004, v. 82 n. 10, p. 919-926 How to Cite? |
Abstract | Previous studies have shown that reactive oxygen species mediated lipid peroxidation in patients undergoing cardiac surgery occurs primarily during cardiopulmonary bypass. We examined whether application of a high concentration of propofol during ischemia could effectively enhance postischemic myocardial functional recovery in the setting of global ischemia and reperfusion in an isolated heart preparation. Hearts were subjected to 40 min of global ischemia followed by 90 min of reperfusion. During ischemia, propofol (12 μg/mL in saline) was perfused through the aorta at 60 μL/min. We found that application of high-concentration propofol during ischemia combined with low-concentration propofol (1.2 μg/mL) administered before ischemia and during reperfusion significantly improved postischemic myocardial functional recovery without depressing cardiac mechanics before ischemia, as is seen when high-concentration propofol was applied prior to ischemia and during reperfusion. The functional enhancement is associated with increased heart tissue antioxidant capacity and reduced lipid peroxidation. We conclude that high-concentration propofol application during ischemia could be a potential therapeutic and anesthetic strategy for patients with preexisting myocardial dysfunction. |
Persistent Identifier | http://hdl.handle.net/10722/147209 |
ISSN | 2023 Impact Factor: 1.7 2023 SCImago Journal Rankings: 0.499 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Xia, Z | en_US |
dc.contributor.author | Godin, DV | en_US |
dc.contributor.author | Ansley, DM | en_US |
dc.date.accessioned | 2012-05-29T06:00:48Z | - |
dc.date.available | 2012-05-29T06:00:48Z | - |
dc.date.issued | 2004 | en_US |
dc.identifier.citation | Canadian Journal Of Physiology And Pharmacology, 2004, v. 82 n. 10, p. 919-926 | en_US |
dc.identifier.issn | 0008-4212 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/147209 | - |
dc.description.abstract | Previous studies have shown that reactive oxygen species mediated lipid peroxidation in patients undergoing cardiac surgery occurs primarily during cardiopulmonary bypass. We examined whether application of a high concentration of propofol during ischemia could effectively enhance postischemic myocardial functional recovery in the setting of global ischemia and reperfusion in an isolated heart preparation. Hearts were subjected to 40 min of global ischemia followed by 90 min of reperfusion. During ischemia, propofol (12 μg/mL in saline) was perfused through the aorta at 60 μL/min. We found that application of high-concentration propofol during ischemia combined with low-concentration propofol (1.2 μg/mL) administered before ischemia and during reperfusion significantly improved postischemic myocardial functional recovery without depressing cardiac mechanics before ischemia, as is seen when high-concentration propofol was applied prior to ischemia and during reperfusion. The functional enhancement is associated with increased heart tissue antioxidant capacity and reduced lipid peroxidation. We conclude that high-concentration propofol application during ischemia could be a potential therapeutic and anesthetic strategy for patients with preexisting myocardial dysfunction. | en_US |
dc.language | eng | en_US |
dc.publisher | N R C Research Press. The Journal's web site is located at http://pubs.nrc-cnrc.gc.ca/cgi-bin/rp/rp2_desc_e?cjpp | en_US |
dc.relation.ispartof | Canadian Journal of Physiology and Pharmacology | en_US |
dc.subject | Heart | - |
dc.subject | Ischemia | - |
dc.subject | Oxidative stress | - |
dc.subject | Propofol | - |
dc.subject | Rat | - |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Antioxidants - Metabolism | en_US |
dc.subject.mesh | Heart - Drug Effects - Physiology | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Myocardial Ischemia - Drug Therapy - Metabolism | en_US |
dc.subject.mesh | Myocardium - Metabolism | en_US |
dc.subject.mesh | Propofol - Administration & Dosage | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Rats, Sprague-Dawley | en_US |
dc.title | Application of high-dose propofol during ischemia improves postischemic function of rat hearts: Effects on tissue antioxidant capacity | en_US |
dc.type | Article | en_US |
dc.identifier.email | Xia, Z:zyxia@hkucc.hku.hk | en_US |
dc.identifier.authority | Xia, Z=rp00532 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1139/y04-097 | en_US |
dc.identifier.pmid | 15573153 | - |
dc.identifier.scopus | eid_2-s2.0-13544258769 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-13544258769&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 82 | en_US |
dc.identifier.issue | 10 | en_US |
dc.identifier.spage | 919 | en_US |
dc.identifier.epage | 926 | en_US |
dc.identifier.isi | WOS:000226483800014 | - |
dc.publisher.place | Canada | en_US |
dc.identifier.issnl | 0008-4212 | - |