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Article: Application of high-dose propofol during ischemia improves postischemic function of rat hearts: Effects on tissue antioxidant capacity

TitleApplication of high-dose propofol during ischemia improves postischemic function of rat hearts: Effects on tissue antioxidant capacity
Authors
Issue Date2004
PublisherN R C Research Press. The Journal's web site is located at http://pubs.nrc-cnrc.gc.ca/cgi-bin/rp/rp2_desc_e?cjpp
Citation
Canadian Journal Of Physiology And Pharmacology, 2004, v. 82 n. 10, p. 919-926 How to Cite?
AbstractPrevious studies have shown that reactive oxygen species mediated lipid peroxidation in patients undergoing cardiac surgery occurs primarily during cardiopulmonary bypass. We examined whether application of a high concentration of propofol during ischemia could effectively enhance postischemic myocardial functional recovery in the setting of global ischemia and reperfusion in an isolated heart preparation. Hearts were subjected to 40 min of global ischemia followed by 90 min of reperfusion. During ischemia, propofol (12 μg/mL in saline) was perfused through the aorta at 60 μL/min. We found that application of high-concentration propofol during ischemia combined with low-concentration propofol (1.2 μg/mL) administered before ischemia and during reperfusion significantly improved postischemic myocardial functional recovery without depressing cardiac mechanics before ischemia, as is seen when high-concentration propofol was applied prior to ischemia and during reperfusion. The functional enhancement is associated with increased heart tissue antioxidant capacity and reduced lipid peroxidation. We conclude that high-concentration propofol application during ischemia could be a potential therapeutic and anesthetic strategy for patients with preexisting myocardial dysfunction.
Persistent Identifierhttp://hdl.handle.net/10722/147209
ISSN
2014 Impact Factor: 1.770
2014 SCImago Journal Rankings: 0.611
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorXia, Zen_US
dc.contributor.authorGodin, DVen_US
dc.contributor.authorAnsley, DMen_US
dc.date.accessioned2012-05-29T06:00:48Z-
dc.date.available2012-05-29T06:00:48Z-
dc.date.issued2004en_US
dc.identifier.citationCanadian Journal Of Physiology And Pharmacology, 2004, v. 82 n. 10, p. 919-926en_US
dc.identifier.issn0008-4212en_US
dc.identifier.urihttp://hdl.handle.net/10722/147209-
dc.description.abstractPrevious studies have shown that reactive oxygen species mediated lipid peroxidation in patients undergoing cardiac surgery occurs primarily during cardiopulmonary bypass. We examined whether application of a high concentration of propofol during ischemia could effectively enhance postischemic myocardial functional recovery in the setting of global ischemia and reperfusion in an isolated heart preparation. Hearts were subjected to 40 min of global ischemia followed by 90 min of reperfusion. During ischemia, propofol (12 μg/mL in saline) was perfused through the aorta at 60 μL/min. We found that application of high-concentration propofol during ischemia combined with low-concentration propofol (1.2 μg/mL) administered before ischemia and during reperfusion significantly improved postischemic myocardial functional recovery without depressing cardiac mechanics before ischemia, as is seen when high-concentration propofol was applied prior to ischemia and during reperfusion. The functional enhancement is associated with increased heart tissue antioxidant capacity and reduced lipid peroxidation. We conclude that high-concentration propofol application during ischemia could be a potential therapeutic and anesthetic strategy for patients with preexisting myocardial dysfunction.en_US
dc.languageengen_US
dc.publisherN R C Research Press. The Journal's web site is located at http://pubs.nrc-cnrc.gc.ca/cgi-bin/rp/rp2_desc_e?cjppen_US
dc.relation.ispartofCanadian Journal of Physiology and Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntioxidants - Metabolismen_US
dc.subject.meshHeart - Drug Effects - Physiologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMyocardial Ischemia - Drug Therapy - Metabolismen_US
dc.subject.meshMyocardium - Metabolismen_US
dc.subject.meshPropofol - Administration & Dosageen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.titleApplication of high-dose propofol during ischemia improves postischemic function of rat hearts: Effects on tissue antioxidant capacityen_US
dc.typeArticleen_US
dc.identifier.emailXia, Z:zyxia@hkucc.hku.hken_US
dc.identifier.authorityXia, Z=rp00532en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1139/y04-097en_US
dc.identifier.pmid15573153-
dc.identifier.scopuseid_2-s2.0-13544258769en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-13544258769&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume82en_US
dc.identifier.issue10en_US
dc.identifier.spage919en_US
dc.identifier.epage926en_US
dc.identifier.isiWOS:000226483800014-
dc.publisher.placeCanadaen_US

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