File Download
  • No File Attached
 
Links for fulltext
(May Require Subscription)
 
Supplementary

Article: Application of high-dose propofol during ischemia improves postischemic function of rat hearts: Effects on tissue antioxidant capacity
  • Basic View
  • Metadata View
  • XML View
TitleApplication of high-dose propofol during ischemia improves postischemic function of rat hearts: Effects on tissue antioxidant capacity
 
AuthorsXia, Z1 1
Godin, DV1
Ansley, DM1 1
 
Issue Date2004
 
PublisherN R C Research Press. The Journal's web site is located at http://pubs.nrc-cnrc.gc.ca/cgi-bin/rp/rp2_desc_e?cjpp
 
CitationCanadian Journal Of Physiology And Pharmacology, 2004, v. 82 n. 10, p. 919-926 [How to Cite?]
DOI: http://dx.doi.org/10.1139/y04-097
 
AbstractPrevious studies have shown that reactive oxygen species mediated lipid peroxidation in patients undergoing cardiac surgery occurs primarily during cardiopulmonary bypass. We examined whether application of a high concentration of propofol during ischemia could effectively enhance postischemic myocardial functional recovery in the setting of global ischemia and reperfusion in an isolated heart preparation. Hearts were subjected to 40 min of global ischemia followed by 90 min of reperfusion. During ischemia, propofol (12 μg/mL in saline) was perfused through the aorta at 60 μL/min. We found that application of high-concentration propofol during ischemia combined with low-concentration propofol (1.2 μg/mL) administered before ischemia and during reperfusion significantly improved postischemic myocardial functional recovery without depressing cardiac mechanics before ischemia, as is seen when high-concentration propofol was applied prior to ischemia and during reperfusion. The functional enhancement is associated with increased heart tissue antioxidant capacity and reduced lipid peroxidation. We conclude that high-concentration propofol application during ischemia could be a potential therapeutic and anesthetic strategy for patients with preexisting myocardial dysfunction.
 
ISSN0008-4212
2012 Impact Factor: 1.556
2012 SCImago Journal Rankings: 0.550
 
DOIhttp://dx.doi.org/10.1139/y04-097
 
ISI Accession Number IDWOS:000226483800014
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorXia, Z
 
dc.contributor.authorGodin, DV
 
dc.contributor.authorAnsley, DM
 
dc.date.accessioned2012-05-29T06:00:48Z
 
dc.date.available2012-05-29T06:00:48Z
 
dc.date.issued2004
 
dc.description.abstractPrevious studies have shown that reactive oxygen species mediated lipid peroxidation in patients undergoing cardiac surgery occurs primarily during cardiopulmonary bypass. We examined whether application of a high concentration of propofol during ischemia could effectively enhance postischemic myocardial functional recovery in the setting of global ischemia and reperfusion in an isolated heart preparation. Hearts were subjected to 40 min of global ischemia followed by 90 min of reperfusion. During ischemia, propofol (12 μg/mL in saline) was perfused through the aorta at 60 μL/min. We found that application of high-concentration propofol during ischemia combined with low-concentration propofol (1.2 μg/mL) administered before ischemia and during reperfusion significantly improved postischemic myocardial functional recovery without depressing cardiac mechanics before ischemia, as is seen when high-concentration propofol was applied prior to ischemia and during reperfusion. The functional enhancement is associated with increased heart tissue antioxidant capacity and reduced lipid peroxidation. We conclude that high-concentration propofol application during ischemia could be a potential therapeutic and anesthetic strategy for patients with preexisting myocardial dysfunction.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationCanadian Journal Of Physiology And Pharmacology, 2004, v. 82 n. 10, p. 919-926 [How to Cite?]
DOI: http://dx.doi.org/10.1139/y04-097
 
dc.identifier.doihttp://dx.doi.org/10.1139/y04-097
 
dc.identifier.epage926
 
dc.identifier.isiWOS:000226483800014
 
dc.identifier.issn0008-4212
2012 Impact Factor: 1.556
2012 SCImago Journal Rankings: 0.550
 
dc.identifier.issue10
 
dc.identifier.pmid15573153
 
dc.identifier.scopuseid_2-s2.0-13544258769
 
dc.identifier.spage919
 
dc.identifier.urihttp://hdl.handle.net/10722/147209
 
dc.identifier.volume82
 
dc.languageeng
 
dc.publisherN R C Research Press. The Journal's web site is located at http://pubs.nrc-cnrc.gc.ca/cgi-bin/rp/rp2_desc_e?cjpp
 
dc.publisher.placeCanada
 
dc.relation.ispartofCanadian Journal of Physiology and Pharmacology
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAnimals
 
dc.subject.meshAntioxidants - Metabolism
 
dc.subject.meshHeart - Drug Effects - Physiology
 
dc.subject.meshMale
 
dc.subject.meshMyocardial Ischemia - Drug Therapy - Metabolism
 
dc.subject.meshMyocardium - Metabolism
 
dc.subject.meshPropofol - Administration & Dosage
 
dc.subject.meshRats
 
dc.subject.meshRats, Sprague-Dawley
 
dc.titleApplication of high-dose propofol during ischemia improves postischemic function of rat hearts: Effects on tissue antioxidant capacity
 
dc.typeArticle
 
<?xml encoding="utf-8" version="1.0"?>
<item><contributor.author>Xia, Z</contributor.author>
<contributor.author>Godin, DV</contributor.author>
<contributor.author>Ansley, DM</contributor.author>
<date.accessioned>2012-05-29T06:00:48Z</date.accessioned>
<date.available>2012-05-29T06:00:48Z</date.available>
<date.issued>2004</date.issued>
<identifier.citation>Canadian Journal Of Physiology And Pharmacology, 2004, v. 82 n. 10, p. 919-926</identifier.citation>
<identifier.issn>0008-4212</identifier.issn>
<identifier.uri>http://hdl.handle.net/10722/147209</identifier.uri>
<description.abstract>Previous studies have shown that reactive oxygen species mediated lipid peroxidation in patients undergoing cardiac surgery occurs primarily during cardiopulmonary bypass. We examined whether application of a high concentration of propofol during ischemia could effectively enhance postischemic myocardial functional recovery in the setting of global ischemia and reperfusion in an isolated heart preparation. Hearts were subjected to 40 min of global ischemia followed by 90 min of reperfusion. During ischemia, propofol (12 &#956;g/mL in saline) was perfused through the aorta at 60 &#956;L/min. We found that application of high-concentration propofol during ischemia combined with low-concentration propofol (1.2 &#956;g/mL) administered before ischemia and during reperfusion significantly improved postischemic myocardial functional recovery without depressing cardiac mechanics before ischemia, as is seen when high-concentration propofol was applied prior to ischemia and during reperfusion. The functional enhancement is associated with increased heart tissue antioxidant capacity and reduced lipid peroxidation. We conclude that high-concentration propofol application during ischemia could be a potential therapeutic and anesthetic strategy for patients with preexisting myocardial dysfunction.</description.abstract>
<language>eng</language>
<publisher>N R C Research Press. The Journal&apos;s web site is located at http://pubs.nrc-cnrc.gc.ca/cgi-bin/rp/rp2_desc_e?cjpp</publisher>
<relation.ispartof>Canadian Journal of Physiology and Pharmacology</relation.ispartof>
<subject.mesh>Animals</subject.mesh>
<subject.mesh>Antioxidants - Metabolism</subject.mesh>
<subject.mesh>Heart - Drug Effects - Physiology</subject.mesh>
<subject.mesh>Male</subject.mesh>
<subject.mesh>Myocardial Ischemia - Drug Therapy - Metabolism</subject.mesh>
<subject.mesh>Myocardium - Metabolism</subject.mesh>
<subject.mesh>Propofol - Administration &amp; Dosage</subject.mesh>
<subject.mesh>Rats</subject.mesh>
<subject.mesh>Rats, Sprague-Dawley</subject.mesh>
<title>Application of high-dose propofol during ischemia improves postischemic function of rat hearts: Effects on tissue antioxidant capacity</title>
<type>Article</type>
<description.nature>Link_to_subscribed_fulltext</description.nature>
<identifier.doi>10.1139/y04-097</identifier.doi>
<identifier.pmid>15573153</identifier.pmid>
<identifier.scopus>eid_2-s2.0-13544258769</identifier.scopus>
<relation.references>http://www.scopus.com/mlt/select.url?eid=2-s2.0-13544258769&amp;selection=ref&amp;src=s&amp;origin=recordpage</relation.references>
<identifier.volume>82</identifier.volume>
<identifier.issue>10</identifier.issue>
<identifier.spage>919</identifier.spage>
<identifier.epage>926</identifier.epage>
<identifier.isi>WOS:000226483800014</identifier.isi>
<publisher.place>Canada</publisher.place>
</item>
Author Affiliations
  1. The University of British Columbia