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Article: Remote preconditioning lessens the deterioration of pulmonary function after repeated coronary artery occlusion and reperfusion in sheep

TitleRemote preconditioning lessens the deterioration of pulmonary function after repeated coronary artery occlusion and reperfusion in sheep
Authors
Issue Date2003
PublisherCanadian Anesthesiologists' Society. The Journal's web site is located at http://www.cja-jca.org/
Citation
Canadian Journal Of Anesthesia, 2003, v. 50 n. 5, p. 481-488 How to Cite?
AbstractPurpose: We investigated whether remote organ preconditioning (RPC) can preserve pulmonary function following repeated myocardial ischemia/reperfusion in a model mimicking multi-vessel off-pump coronary artery bypass (OPCAB) revascularization. Methods: Nine sheep (Group-RPC) underwent RPC by three episodes of five-minute occlusion and five-minute reperfusion of the iliac artery. Five sheep (Group-C) were time-matched controls. Afterwards, ten-minute occlusion and reperfusion of the left anterior descending, the first diagonal and the left circumflex coronary arteries were performed consecutively. Hemodynamic and respiratory parameters and arterial blood gases were measured until 120 min after the final coronary reperfusion. Anesthesia was maintained with halothane in oxygen and nitrous oxide. Animals were ventilated with a tidal volume of 15-20 mL·kg -1 in a non-rebreathing system, and a respiratory rate 14-16 min, with 5-cm H 2O positive end expiratory pressure after thoracotomy. Results: Repeated coronary occlusion and reperfusion was associated in this experimental model with an increase in pulmonary vascular resistance (PVR) and pulmonary arterial pressure (PAP) and a decrease in PaO 2 and PaO 2/FlO 2 in Group-C. After 120 min reperfusion, PaO 2 and PaO 2/FlO 2 in Group-RPC were higher (192 ± 69 mmHg and 241 ± 78 vs 115 ± 54 mmHg and 129 ± 64, P < 0.05), while PVR and PAP were lower than in Group-C. At 120 min of reperfusion, PaO 2 and PaO 2/FlO 2 were inversely correlated with PVR (P < 0.01). Conclusions: RPC by transient occlusion of the iliac artery improves lung gas exchange after repeated coronary artery occlusion and reperfusion mimicking OPCAB surgery, and preserves low PVR in sheep.
Persistent Identifierhttp://hdl.handle.net/10722/147201
ISSN
2015 Impact Factor: 2.139
2015 SCImago Journal Rankings: 0.884
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorXia, Zen_US
dc.contributor.authorHerijgers, Pen_US
dc.contributor.authorNishida, Ten_US
dc.contributor.authorOzaki, Sen_US
dc.contributor.authorWouters, Pen_US
dc.contributor.authorFlameng, Wen_US
dc.date.accessioned2012-05-29T06:00:45Z-
dc.date.available2012-05-29T06:00:45Z-
dc.date.issued2003en_US
dc.identifier.citationCanadian Journal Of Anesthesia, 2003, v. 50 n. 5, p. 481-488en_US
dc.identifier.issn0832-610Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/147201-
dc.description.abstractPurpose: We investigated whether remote organ preconditioning (RPC) can preserve pulmonary function following repeated myocardial ischemia/reperfusion in a model mimicking multi-vessel off-pump coronary artery bypass (OPCAB) revascularization. Methods: Nine sheep (Group-RPC) underwent RPC by three episodes of five-minute occlusion and five-minute reperfusion of the iliac artery. Five sheep (Group-C) were time-matched controls. Afterwards, ten-minute occlusion and reperfusion of the left anterior descending, the first diagonal and the left circumflex coronary arteries were performed consecutively. Hemodynamic and respiratory parameters and arterial blood gases were measured until 120 min after the final coronary reperfusion. Anesthesia was maintained with halothane in oxygen and nitrous oxide. Animals were ventilated with a tidal volume of 15-20 mL·kg -1 in a non-rebreathing system, and a respiratory rate 14-16 min, with 5-cm H 2O positive end expiratory pressure after thoracotomy. Results: Repeated coronary occlusion and reperfusion was associated in this experimental model with an increase in pulmonary vascular resistance (PVR) and pulmonary arterial pressure (PAP) and a decrease in PaO 2 and PaO 2/FlO 2 in Group-C. After 120 min reperfusion, PaO 2 and PaO 2/FlO 2 in Group-RPC were higher (192 ± 69 mmHg and 241 ± 78 vs 115 ± 54 mmHg and 129 ± 64, P < 0.05), while PVR and PAP were lower than in Group-C. At 120 min of reperfusion, PaO 2 and PaO 2/FlO 2 were inversely correlated with PVR (P < 0.01). Conclusions: RPC by transient occlusion of the iliac artery improves lung gas exchange after repeated coronary artery occlusion and reperfusion mimicking OPCAB surgery, and preserves low PVR in sheep.en_US
dc.languageengen_US
dc.publisherCanadian Anesthesiologists' Society. The Journal's web site is located at http://www.cja-jca.org/en_US
dc.relation.ispartofCanadian Journal of Anesthesiaen_US
dc.subject.meshAnalysis Of Varianceen_US
dc.subject.meshAnesthetics, Inhalation - Therapeutic Useen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBlood Gas Analysisen_US
dc.subject.meshCoronary Circulation - Physiologyen_US
dc.subject.meshCoronary Vessels - Physiopathologyen_US
dc.subject.meshDisease Models, Animalen_US
dc.subject.meshHalothane - Therapeutic Useen_US
dc.subject.meshHemodynamics - Physiologyen_US
dc.subject.meshIliac Artery - Physiologyen_US
dc.subject.meshIschemic Preconditioningen_US
dc.subject.meshLung - Blood Supply - Physiopathologyen_US
dc.subject.meshMyocardial Ischemia - Physiopathologyen_US
dc.subject.meshMyocardial Reperfusionen_US
dc.subject.meshNitrous Oxide - Therapeutic Useen_US
dc.subject.meshSheepen_US
dc.subject.meshTime Factorsen_US
dc.subject.meshVascular Resistance - Physiologyen_US
dc.titleRemote preconditioning lessens the deterioration of pulmonary function after repeated coronary artery occlusion and reperfusion in sheepen_US
dc.typeArticleen_US
dc.identifier.emailXia, Z:zyxia@hkucc.hku.hken_US
dc.identifier.authorityXia, Z=rp00532en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid12734158-
dc.identifier.scopuseid_2-s2.0-0037966572en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037966572&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume50en_US
dc.identifier.issue5en_US
dc.identifier.spage481en_US
dc.identifier.epage488en_US
dc.identifier.isiWOS:000182906900011-
dc.publisher.placeCanadaen_US

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