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Article: Morphine and methadone have different effects on calcium channel currents in neuroblastoma cells

TitleMorphine and methadone have different effects on calcium channel currents in neuroblastoma cells
Authors
Issue Date2000
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainres
Citation
Brain Research, 2000, v. 870 n. 1-2, p. 199-203 How to Cite?
AbstractUsing patch-clamp technique, cellular calcium channel currents were studied on nine mouse neuroblastoma N1E115 cells. Both morphine and methadone decreased the T-type calcium currents in dose-dependent fashion. These effects were partially blocked by naloxane. On L-type calcium currents, morphine showed no effect. However, methadone inhibited the L-calcium currents in dose-dependent fashion. This effect was not antagonised by naloxone. Hence, the action of methadone on L-calcium channel is probably not associated with μ receptors. (C) 2000 Elsevier Science B.V.
Persistent Identifierhttp://hdl.handle.net/10722/147191
ISSN
2015 Impact Factor: 2.561
2015 SCImago Journal Rankings: 1.351
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYang, JCen_US
dc.contributor.authorShan, Jen_US
dc.contributor.authorNg, KFen_US
dc.contributor.authorPang, Pen_US
dc.date.accessioned2012-05-29T06:00:41Z-
dc.date.available2012-05-29T06:00:41Z-
dc.date.issued2000en_US
dc.identifier.citationBrain Research, 2000, v. 870 n. 1-2, p. 199-203en_US
dc.identifier.issn0006-8993en_US
dc.identifier.urihttp://hdl.handle.net/10722/147191-
dc.description.abstractUsing patch-clamp technique, cellular calcium channel currents were studied on nine mouse neuroblastoma N1E115 cells. Both morphine and methadone decreased the T-type calcium currents in dose-dependent fashion. These effects were partially blocked by naloxane. On L-type calcium currents, morphine showed no effect. However, methadone inhibited the L-calcium currents in dose-dependent fashion. This effect was not antagonised by naloxone. Hence, the action of methadone on L-calcium channel is probably not associated with μ receptors. (C) 2000 Elsevier Science B.V.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainresen_US
dc.relation.ispartofBrain Researchen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCalcium Channels - Physiologyen_US
dc.subject.meshMembrane Potentials - Drug Effects - Physiologyen_US
dc.subject.meshMethadone - Pharmacologyen_US
dc.subject.meshMiceen_US
dc.subject.meshMorphine - Pharmacologyen_US
dc.subject.meshNaloxone - Pharmacologyen_US
dc.subject.meshNarcotic Antagonists - Pharmacologyen_US
dc.subject.meshNarcotics - Pharmacologyen_US
dc.subject.meshNeuroblastomaen_US
dc.subject.meshNeurons - Drug Effects - Physiologyen_US
dc.subject.meshPatch-Clamp Techniquesen_US
dc.subject.meshTumor Cells, Cultureden_US
dc.titleMorphine and methadone have different effects on calcium channel currents in neuroblastoma cellsen_US
dc.typeArticleen_US
dc.identifier.emailNg, KF:jkfng@hkucc.hku.hken_US
dc.identifier.authorityNg, KF=rp00544en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0006-8993(00)02369-6en_US
dc.identifier.pmid10869519-
dc.identifier.scopuseid_2-s2.0-0034617475en_US
dc.identifier.hkuros57123-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034617475&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume870en_US
dc.identifier.issue1-2en_US
dc.identifier.spage199en_US
dc.identifier.epage203en_US
dc.identifier.isiWOS:000087951500025-
dc.publisher.placeNetherlandsen_US

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