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Article: The effect of sudden failure of a rotary blood pump on left ventricular performance in normal and failing hearts

TitleThe effect of sudden failure of a rotary blood pump on left ventricular performance in normal and failing hearts
Authors
Issue Date2000
PublisherBlackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journals/AOR
Citation
Artificial Organs, 2000, v. 24 n. 11, p. 893-898 How to Cite?
AbstractWe investigated the hemodynamic effect of regurgitation (or back-flow) due to sudden failure of a rotary blood pump (diagonal pump). Seven healthy sheep (Group C) and 7 with chronic heart failure (Group F) were studied. Chronic heart failure was obtained by intracoronary injection of microspheres several weeks earlier. Left ventricular function and ventricular efficacy were assessed by the pressure-volume relationship. The back-flow through the stopped pump was significantly lower in Group F (2.3 ± 0.34 L/min) than in Group C (2.8 ± 0.33 L/min). Mean aortic blood pressure dropped significantly from 68.3 ± 9.65 to 61.9 ± 9.75 mm Hg in Group C and from 62.5 ± 9.12 to 51.5 ± 9.08 in Group F but remained stable during the 15 min period of pump stop. Parameters of left ventricular contractility (preload recruitable stroke work) dropped significantly in both groups, remained stable during the pump stop, and returned to baseline values 30 min after the end of back-flow. The ventricular efficacy (in terms of energy transfer) was tolerant against this acute volume overload even in the failing hearts. Sudden pump failure of a rotary blood pump leads to an acute depression of the hemodynamic state and myocardial contractility. However, this depression remained stable over 15 min, did not lead to further deterioration of the animals, and was completely reversible.
Persistent Identifierhttp://hdl.handle.net/10722/147187
ISSN
2015 Impact Factor: 1.993
2015 SCImago Journal Rankings: 0.872
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNishida, Ten_US
dc.contributor.authorMeyns, Ben_US
dc.contributor.authorZietkiewicz, Men_US
dc.contributor.authorPerek, Ben_US
dc.contributor.authorXia, Zen_US
dc.contributor.authorGoebel, Cen_US
dc.contributor.authorReul, Hen_US
dc.contributor.authorFlameng, Wen_US
dc.date.accessioned2012-05-29T06:00:39Z-
dc.date.available2012-05-29T06:00:39Z-
dc.date.issued2000en_US
dc.identifier.citationArtificial Organs, 2000, v. 24 n. 11, p. 893-898en_US
dc.identifier.issn0160-564Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/147187-
dc.description.abstractWe investigated the hemodynamic effect of regurgitation (or back-flow) due to sudden failure of a rotary blood pump (diagonal pump). Seven healthy sheep (Group C) and 7 with chronic heart failure (Group F) were studied. Chronic heart failure was obtained by intracoronary injection of microspheres several weeks earlier. Left ventricular function and ventricular efficacy were assessed by the pressure-volume relationship. The back-flow through the stopped pump was significantly lower in Group F (2.3 ± 0.34 L/min) than in Group C (2.8 ± 0.33 L/min). Mean aortic blood pressure dropped significantly from 68.3 ± 9.65 to 61.9 ± 9.75 mm Hg in Group C and from 62.5 ± 9.12 to 51.5 ± 9.08 in Group F but remained stable during the 15 min period of pump stop. Parameters of left ventricular contractility (preload recruitable stroke work) dropped significantly in both groups, remained stable during the pump stop, and returned to baseline values 30 min after the end of back-flow. The ventricular efficacy (in terms of energy transfer) was tolerant against this acute volume overload even in the failing hearts. Sudden pump failure of a rotary blood pump leads to an acute depression of the hemodynamic state and myocardial contractility. However, this depression remained stable over 15 min, did not lead to further deterioration of the animals, and was completely reversible.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journals/AORen_US
dc.relation.ispartofArtificial Organsen_US
dc.subject.meshAnalysis Of Varianceen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAorta - Physiopathologyen_US
dc.subject.meshBlood Pressure - Physiologyen_US
dc.subject.meshCardiac Output - Physiologyen_US
dc.subject.meshCardiac Output, Low - Physiopathology - Therapyen_US
dc.subject.meshCardiac Volume - Physiologyen_US
dc.subject.meshChronic Diseaseen_US
dc.subject.meshDisease Models, Animalen_US
dc.subject.meshEnergy Transferen_US
dc.subject.meshEquipment Designen_US
dc.subject.meshEquipment Failureen_US
dc.subject.meshHeart-Assist Devicesen_US
dc.subject.meshHemodynamics - Physiologyen_US
dc.subject.meshMyocardial Contraction - Physiologyen_US
dc.subject.meshSheepen_US
dc.subject.meshStroke Volume - Physiologyen_US
dc.subject.meshSurface Propertiesen_US
dc.subject.meshVentricular Function, Left - Physiologyen_US
dc.subject.meshVentricular Pressure - Physiologyen_US
dc.titleThe effect of sudden failure of a rotary blood pump on left ventricular performance in normal and failing heartsen_US
dc.typeArticleen_US
dc.identifier.emailXia, Z:zyxia@hkucc.hku.hken_US
dc.identifier.authorityXia, Z=rp00532en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1046/j.1525-1594.2000.06549.xen_US
dc.identifier.pmid11119078-
dc.identifier.scopuseid_2-s2.0-0033672880en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033672880&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume24en_US
dc.identifier.issue11en_US
dc.identifier.spage893en_US
dc.identifier.epage898en_US
dc.identifier.isiWOS:000165720400010-
dc.publisher.placeUnited Statesen_US

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