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Article: Patient-maintained propofol sedation. Assessment of a target-controlled infusion system

TitlePatient-maintained propofol sedation. Assessment of a target-controlled infusion system
Authors
Issue Date1997
PublisherWiley-Blackwell Publishing Ltd. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0003-2409
Citation
Anaesthesia, 1997, v. 52 n. 6, p. 525-530 How to Cite?
AbstractWe have developed a system which allows patients to operate a target-controlled infusion of propofol to provide sedation and we have studied its use in 36 unpremedicated patients undergoing local and regional anaesthetic procedures lasting 10-280 min. An intravenous propofol infusion was started at a target plasma level of 1 μg.ml-1. The patient was able to increase the target propofol concentration in 0.2-μg.ml-1 increments by pressing a demand button. There was a lockout interval of 2 min and a maximum permissible target concentration of 3 μg.ml-1. There was considerable interindividual variability in propofol consumption (mean 39.3 μg.kg-1.min-1, range 3-131 μg.kg-1.min-1), no cardiovascular instability and little oversedation. Eight patients required supplementary oxygen. Optimal sedation was provided at median target concentrations of 0.8-0.9 μg.ml-1. The target-controlled infusion system bias was -47% and the inaccuracy was 48%. Patient satisfaction was high and 89% said that they would definitely use the technique again. This technique combines the benefits of target-controlled infusion with patient-controlled feedback and produces safe intra-operative sedation.
Persistent Identifierhttp://hdl.handle.net/10722/147180
ISSN
2015 Impact Factor: 3.794
2015 SCImago Journal Rankings: 1.404
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorIrwin, MGen_US
dc.contributor.authorThompson, Nen_US
dc.contributor.authorKenny, GNCen_US
dc.date.accessioned2012-05-29T06:00:36Z-
dc.date.available2012-05-29T06:00:36Z-
dc.date.issued1997en_US
dc.identifier.citationAnaesthesia, 1997, v. 52 n. 6, p. 525-530en_US
dc.identifier.issn0003-2409en_US
dc.identifier.urihttp://hdl.handle.net/10722/147180-
dc.description.abstractWe have developed a system which allows patients to operate a target-controlled infusion of propofol to provide sedation and we have studied its use in 36 unpremedicated patients undergoing local and regional anaesthetic procedures lasting 10-280 min. An intravenous propofol infusion was started at a target plasma level of 1 μg.ml-1. The patient was able to increase the target propofol concentration in 0.2-μg.ml-1 increments by pressing a demand button. There was a lockout interval of 2 min and a maximum permissible target concentration of 3 μg.ml-1. There was considerable interindividual variability in propofol consumption (mean 39.3 μg.kg-1.min-1, range 3-131 μg.kg-1.min-1), no cardiovascular instability and little oversedation. Eight patients required supplementary oxygen. Optimal sedation was provided at median target concentrations of 0.8-0.9 μg.ml-1. The target-controlled infusion system bias was -47% and the inaccuracy was 48%. Patient satisfaction was high and 89% said that they would definitely use the technique again. This technique combines the benefits of target-controlled infusion with patient-controlled feedback and produces safe intra-operative sedation.en_US
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing Ltd. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0003-2409en_US
dc.relation.ispartofAnaesthesiaen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAnesthesia, Conductionen_US
dc.subject.meshBlood Pressure - Drug Effectsen_US
dc.subject.meshConscious Sedation - Methods - Psychologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHeart Rate - Drug Effectsen_US
dc.subject.meshHumansen_US
dc.subject.meshHypnotics And Sedatives - Administration & Dosage - Pharmacologyen_US
dc.subject.meshInfusions, Intravenousen_US
dc.subject.meshIntraoperative Care - Methodsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPatient Satisfactionen_US
dc.subject.meshPropofol - Administration & Dosage - Pharmacologyen_US
dc.subject.meshRespiration - Drug Effectsen_US
dc.subject.meshSelf Administrationen_US
dc.titlePatient-maintained propofol sedation. Assessment of a target-controlled infusion systemen_US
dc.typeArticleen_US
dc.identifier.emailIrwin, MG:mgirwin@hku.hken_US
dc.identifier.authorityIrwin, MG=rp00390en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.pmid9203877-
dc.identifier.scopuseid_2-s2.0-0030919320en_US
dc.identifier.hkuros22747-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030919320&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume52en_US
dc.identifier.issue6en_US
dc.identifier.spage525en_US
dc.identifier.epage530en_US
dc.identifier.isiWOS:A1997XD55500004-
dc.publisher.placeUnited Kingdomen_US

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