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Article: Premedication with oral midazolam in children - An assessment of psychomotor function, anxiolysis, sedation and pharmacokinetics

TitlePremedication with oral midazolam in children - An assessment of psychomotor function, anxiolysis, sedation and pharmacokinetics
Authors
Issue Date1994
PublisherAustralian Society of Anaesthetists. The Journal's web site is located at http://www.aaic.net.au
Citation
Anaesthesia And Intensive Care, 1994, v. 22 n. 5, p. 539-544 How to Cite?
AbstractWe studied 30 children, aged 4 to 12 years, undergoing elective circumcision, premedicated with midazolam 0.5 mg.kg-1 and atropine 0.02 mg.kg-1 by mouth. A modified postbox test and the coding component of the Wechsler intelligence scale (WISC-R) was used to assess the preoperative effect of premedication on psychomotor function. Mood and sedation were also scored and related to serum midazolam concentrations. The children showed a significant decline in psychomotor performance 30 and 60 minutes after premedication when compared with their best unmedicated performance recorded the previous evening. This decline in psychomotor performance was only weakly associated with serum midazolam concentrations (r = 0.1). The postbox toy ratio is a suitable measurement of psychomotor performance in children because of its simplicity and ease of use in the clinical environment, although it may suffer the 'test-retest' limitations of similar types of assessment. The sedative and anxiolytic effects of midazolam provide a quiet environment for a smooth induction of anaesthesia.
Persistent Identifierhttp://hdl.handle.net/10722/147165
ISSN
2015 Impact Factor: 1.283
2015 SCImago Journal Rankings: 0.488
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorJones, RDMen_US
dc.contributor.authorVisram, ARen_US
dc.contributor.authorKornberg, JPen_US
dc.contributor.authorIrwin, MGen_US
dc.contributor.authorGunawardene, WMSen_US
dc.date.accessioned2012-05-29T06:00:30Z-
dc.date.available2012-05-29T06:00:30Z-
dc.date.issued1994en_US
dc.identifier.citationAnaesthesia And Intensive Care, 1994, v. 22 n. 5, p. 539-544en_US
dc.identifier.issn0310-057Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/147165-
dc.description.abstractWe studied 30 children, aged 4 to 12 years, undergoing elective circumcision, premedicated with midazolam 0.5 mg.kg-1 and atropine 0.02 mg.kg-1 by mouth. A modified postbox test and the coding component of the Wechsler intelligence scale (WISC-R) was used to assess the preoperative effect of premedication on psychomotor function. Mood and sedation were also scored and related to serum midazolam concentrations. The children showed a significant decline in psychomotor performance 30 and 60 minutes after premedication when compared with their best unmedicated performance recorded the previous evening. This decline in psychomotor performance was only weakly associated with serum midazolam concentrations (r = 0.1). The postbox toy ratio is a suitable measurement of psychomotor performance in children because of its simplicity and ease of use in the clinical environment, although it may suffer the 'test-retest' limitations of similar types of assessment. The sedative and anxiolytic effects of midazolam provide a quiet environment for a smooth induction of anaesthesia.en_US
dc.languageengen_US
dc.publisherAustralian Society of Anaesthetists. The Journal's web site is located at http://www.aaic.net.auen_US
dc.relation.ispartofAnaesthesia and Intensive Careen_US
dc.subject.meshAdministration, Oralen_US
dc.subject.meshAffect - Drug Effectsen_US
dc.subject.meshAnxiety - Prevention & Controlen_US
dc.subject.meshAtropine - Administration & Dosageen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshCircumcision, Maleen_US
dc.subject.meshConscious Sedationen_US
dc.subject.meshHumansen_US
dc.subject.meshIrritable Mood - Drug Effectsen_US
dc.subject.meshMaleen_US
dc.subject.meshMidazolam - Administration & Dosage - Blood - Pharmacokinetics - Pharmacologyen_US
dc.subject.meshPhimosis - Surgeryen_US
dc.subject.meshPreanesthetic Medicationen_US
dc.subject.meshPsychomotor Performance - Drug Effectsen_US
dc.subject.meshTime Factorsen_US
dc.subject.meshWakefulness - Drug Effectsen_US
dc.titlePremedication with oral midazolam in children - An assessment of psychomotor function, anxiolysis, sedation and pharmacokineticsen_US
dc.typeArticleen_US
dc.identifier.emailIrwin, MG:mgirwin@hku.hken_US
dc.identifier.authorityIrwin, MG=rp00390en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid7818057en_US
dc.identifier.scopuseid_2-s2.0-0027944156en_US
dc.identifier.volume22en_US
dc.identifier.issue5en_US
dc.identifier.spage539en_US
dc.identifier.epage544en_US
dc.identifier.isiWOS:A1994PM92700005-
dc.publisher.placeAustraliaen_US

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