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Article: Association of handgrip strength with chronic diseases and multimorbidity - A cross-sectional study

TitleAssociation of handgrip strength with chronic diseases and multimorbidity - A cross-sectional study
Authors
KeywordsAssociation
Chronic disease
Handgrip strength
Multimorbidity
Issue Date2013
PublisherSpringer Netherlands. The Journal's web site is located at http://www.springerlink.com/content/0161-9152/
Citation
Age, 2013, v. 35 n. 3, p. 929-941 How to Cite?
AbstractThe prevalence of chronic diseases has risen along with increased longevity. Co-occurrence of two or more chronic diseases in an individual (multimorbidity) is prevalent and poses a huge burden to individuals and the society. However, determinants of multimorbidity are largely unknown. Handgrip strength is a general indicator of muscle strength and linked with premature mortality. However, its role in multimorbidity has never been evaluated. To investigate the relationships between handgrip strength and multiple chronic diseases and multimorbidity, and to assess the usefulness of age and handgrip as a marker of chronic diseases and multimorbidity in a community dwelling sample of men and women, we analyzed a cross-sectional cohort with 1,145 subjects (748 men and 397 women) aged 50 years and older living in Hong Kong. Low handgrip strength was significantly associated with increased odds of having five and three chronic diseases in men and women, respectively, after controlling for age, body mass index, history of smoking, educational level, marital level and comorbidity. Multivariable-adjusted handgrip strength was significantly decreased with the number of chronic diseases in men (trend, P = 0.001), but the trend in women was marginal (trend, P = 0.06). Conversely, multivariable-adjusted age was significantly increased with the number of chronic diseases in women (trend, P = 0.033), but not in men (trend, P = 0.118). In conclusion, handgrip strength is associated with multiple chronic diseases and multimorbidity in men and women after adjustment of confounding factors. It shows a linear trend of association with the number of chronic diseases in men, but not in women. Since handgrip strength is a biomarker of multiple physiological systems, its augmentation may be a feasible strategy to improve general health and decrease likelihood of having multiple chronic diseases and hence, premature mortality. © 2012 The Author(s).
Persistent Identifierhttp://hdl.handle.net/10722/147088
ISSN
2015 Impact Factor: 2.5
2015 SCImago Journal Rankings: 1.358
PubMed Central ID
ISI Accession Number ID
References

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Barzilay JI, Cotsonis GA, Walston J, Schwartz AV, Satterfield S, Miljkovic I, Harris TB (2009) Insulin resistance is associated with decreased quadriceps muscle strength in nondiabetic adults aged > or =70 years. Diabetes Care 32:736–738 doi: 10.2337/dc08-1781

Baumgartner RN, Waters DL, Gallagher D, Morley JE, Garry PJ (1999) Predictors of skeletal muscle mass in elderly men and women. Mech Ageing Dev 107:123–136 doi: 10.1016/S0047-6374(98)00130-4

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Cheung CL, Huang QY, Ng MY, Chan V, Sham PC, Kung AW (2006) Confirmation of linkage to chromosome 1q for spine bone mineral density in southern Chinese. Hum Genet 120:354–359 doi: 10.1007/s00439-006-0220-3

Filho ST, Lourenco RA, Moreira VG (2010) Comparing indexes of frailty: the cardiovascular health study and the study of osteoporotic fractures. J Am Geriatr Soc 58:383–385, author reply 385–386 doi: 10.1111/j.1532-5415.2009.02690.x

Foley KT, Owings TM, Pavol MJ, Grabiner MD (1999) Maximum grip strength is not related to bone mineral density of the proximal femur in older adults. Calcif Tissue Int 64:291–294 doi: 10.1007/s002239900621

Fortin M, Bravo G, Hudon C, Lapointe L, Almirall J, Dubois MF, Vanasse A (2006) Relationship between multimorbidity and health-related quality of life of patients in primary care. Qual Life Res 15:83–91 doi: 10.1007/s11136-005-8661-z

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DC FieldValueLanguage
dc.contributor.authorCheung, CLen_HK
dc.contributor.authorNguyen, USDTen_HK
dc.contributor.authorAu, Een_HK
dc.contributor.authorTan, KCBen_HK
dc.contributor.authorKung, AWCen_HK
dc.date.accessioned2012-05-25T07:50:34Z-
dc.date.available2012-05-25T07:50:34Z-
dc.date.issued2013en_HK
dc.identifier.citationAge, 2013, v. 35 n. 3, p. 929-941en_HK
dc.identifier.issn0161-9152en_HK
dc.identifier.urihttp://hdl.handle.net/10722/147088-
dc.description.abstractThe prevalence of chronic diseases has risen along with increased longevity. Co-occurrence of two or more chronic diseases in an individual (multimorbidity) is prevalent and poses a huge burden to individuals and the society. However, determinants of multimorbidity are largely unknown. Handgrip strength is a general indicator of muscle strength and linked with premature mortality. However, its role in multimorbidity has never been evaluated. To investigate the relationships between handgrip strength and multiple chronic diseases and multimorbidity, and to assess the usefulness of age and handgrip as a marker of chronic diseases and multimorbidity in a community dwelling sample of men and women, we analyzed a cross-sectional cohort with 1,145 subjects (748 men and 397 women) aged 50 years and older living in Hong Kong. Low handgrip strength was significantly associated with increased odds of having five and three chronic diseases in men and women, respectively, after controlling for age, body mass index, history of smoking, educational level, marital level and comorbidity. Multivariable-adjusted handgrip strength was significantly decreased with the number of chronic diseases in men (trend, P = 0.001), but the trend in women was marginal (trend, P = 0.06). Conversely, multivariable-adjusted age was significantly increased with the number of chronic diseases in women (trend, P = 0.033), but not in men (trend, P = 0.118). In conclusion, handgrip strength is associated with multiple chronic diseases and multimorbidity in men and women after adjustment of confounding factors. It shows a linear trend of association with the number of chronic diseases in men, but not in women. Since handgrip strength is a biomarker of multiple physiological systems, its augmentation may be a feasible strategy to improve general health and decrease likelihood of having multiple chronic diseases and hence, premature mortality. © 2012 The Author(s).en_HK
dc.languageengen_US
dc.publisherSpringer Netherlands. The Journal's web site is located at http://www.springerlink.com/content/0161-9152/en_HK
dc.relation.ispartofAgeen_HK
dc.rightsThe Author(s)en_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong Licenseen_US
dc.rightsThe original publication is available at www.springerlink.com-
dc.subjectAssociationen_HK
dc.subjectChronic diseaseen_HK
dc.subjectHandgrip strengthen_HK
dc.subjectMultimorbidityen_HK
dc.titleAssociation of handgrip strength with chronic diseases and multimorbidity - A cross-sectional studyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://www.springerlink.com/link-out/?id=2104&code=Q3K80713755P5532&MUD=MPen_US
dc.identifier.emailCheung, CL: lung1212@hku.hken_HK
dc.identifier.emailTan, KCB: kcbtan@hku.hken_HK
dc.identifier.emailKung, AWC: awckung@hku.hken_HK
dc.identifier.authorityCheung, CL=rp01749en_HK
dc.identifier.authorityTan, KCB=rp00402en_HK
dc.identifier.authorityKung, AWC=rp00368en_HK
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.1007/s11357-012-9385-yen_HK
dc.identifier.pmid22314403-
dc.identifier.pmcidPMC3636411-
dc.identifier.scopuseid_2-s2.0-84880571946en_HK
dc.identifier.hkuros201486-
dc.identifier.hkuros218604-
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dc.identifier.spage929en_HK
dc.identifier.epage941en_HK
dc.identifier.eissn1574-4647en_US
dc.identifier.isiWOS:000318174100031-
dc.publisher.placeNetherlandsen_HK
dc.description.otherSpringer Open Choice, 25 May 2012en_US
dc.identifier.scopusauthoridCheung, CL=14520953400en_HK
dc.identifier.scopusauthoridNguyen, USDT=54949305400en_HK
dc.identifier.scopusauthoridAu, E=54949831900en_HK
dc.identifier.scopusauthoridTan, KCB=8082703100en_HK
dc.identifier.scopusauthoridKung, AWC=7102322339en_HK
dc.identifier.citeulike10336388-

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