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Book Chapter: Holistic approach versus scientific evidence, what do we know about anti-aging herbal medicine in aging-associated neurodegenerative diseases?

TitleHolistic approach versus scientific evidence, what do we know about anti-aging herbal medicine in aging-associated neurodegenerative diseases?
Authors
Issue Date2011
PublisherNova Science Publishers, Inc.
Citation
Holistic approach versus scientific evidence, what do we know about anti-aging herbal medicine in aging-associated neurodegenerative diseases?. In Farooqui, AA and Farooqui, T (Eds.), Phytochemicals and human health, p. 157-186. New York, NY: Nova Science Publishers, Inc., 2011 How to Cite?
Abstract
In Asian countries such as China, Japan and Korea, some herbs are considered to be anti-aging herbs. According to the traditional medicine descriptions, these herbs have beneficial effects on aging-associated diseases and they intervene disease progression through a holistic approach. For a long time, this "holistic approach" statement remains difficult to be interpreted and is considered to be lack of scientific-evidence support. L. barbarum is a commonly used herb in China for both disease treatment and as functional food. It is also famous for its anti-aging properties. In this review, we use L. barbarum as an example to explain the "holistic approach" concept of anti-aging herbs. We discussed its effects on aging-associated neurodegenerative diseases such as glaucoma and Alzheimer's disease (AD). We proposed that the holistic properties of L. barbarum can be reflected in the following areas. Firstly, L. barbarum is a common food ingredient in Eastern countries. Carotenoid and polysaccharides components of L. barbarum are beneficial to the eye and therefore explained why it can be used as food therapy. Secondly, L. barbarum utilize multiple protective mechanisms to protect neurons against pathological damages. L. barbarum can directly modulate a number of intracellular signaling pathways and increase the expression of survival factors to enhance neuronal survival and attenuate apoptosis. On the other hand, L. barbarum indirectly regulate neuronal survival through modulating the activities of the surrounding microglia. Furthermore, L. barbarum provides beneficial effects on a number of aging-associated conditions, which can be risk factors of neurodegenerative diseases. These holistic actions for therapy and prevention may explain why L. barbarum is regarded as an anti-aging herb. © 2011 Nova Science Publishers, Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/147070
ISBN

 

Author Affiliations
  1. Faculty of Medicine
  2. The University of Hong Kong
  3. LKS Faculty of Medicine
DC FieldValueLanguage
dc.contributor.authorHo, YSen_US
dc.contributor.authorChiu, Ken_US
dc.contributor.authorHung, HLen_US
dc.contributor.authorSo, KFen_US
dc.contributor.authorChang, RCCen_US
dc.date.accessioned2012-05-23T05:56:20Z-
dc.date.available2012-05-23T05:56:20Z-
dc.date.issued2011en_US
dc.identifier.citationHolistic approach versus scientific evidence, what do we know about anti-aging herbal medicine in aging-associated neurodegenerative diseases?. In Farooqui, AA and Farooqui, T (Eds.), Phytochemicals and human health, p. 157-186. New York, NY: Nova Science Publishers, Inc., 2011en_US
dc.identifier.isbn9781617611964en_US
dc.identifier.urihttp://hdl.handle.net/10722/147070-
dc.description.abstractIn Asian countries such as China, Japan and Korea, some herbs are considered to be anti-aging herbs. According to the traditional medicine descriptions, these herbs have beneficial effects on aging-associated diseases and they intervene disease progression through a holistic approach. For a long time, this "holistic approach" statement remains difficult to be interpreted and is considered to be lack of scientific-evidence support. L. barbarum is a commonly used herb in China for both disease treatment and as functional food. It is also famous for its anti-aging properties. In this review, we use L. barbarum as an example to explain the "holistic approach" concept of anti-aging herbs. We discussed its effects on aging-associated neurodegenerative diseases such as glaucoma and Alzheimer's disease (AD). We proposed that the holistic properties of L. barbarum can be reflected in the following areas. Firstly, L. barbarum is a common food ingredient in Eastern countries. Carotenoid and polysaccharides components of L. barbarum are beneficial to the eye and therefore explained why it can be used as food therapy. Secondly, L. barbarum utilize multiple protective mechanisms to protect neurons against pathological damages. L. barbarum can directly modulate a number of intracellular signaling pathways and increase the expression of survival factors to enhance neuronal survival and attenuate apoptosis. On the other hand, L. barbarum indirectly regulate neuronal survival through modulating the activities of the surrounding microglia. Furthermore, L. barbarum provides beneficial effects on a number of aging-associated conditions, which can be risk factors of neurodegenerative diseases. These holistic actions for therapy and prevention may explain why L. barbarum is regarded as an anti-aging herb. © 2011 Nova Science Publishers, Inc. All rights reserved.-
dc.languageengen_US
dc.publisherNova Science Publishers, Inc.en_US
dc.relation.ispartofPhytochemicals and human healthen_US
dc.titleHolistic approach versus scientific evidence, what do we know about anti-aging herbal medicine in aging-associated neurodegenerative diseases?en_US
dc.typeBook_Chapteren_US
dc.identifier.emailHo, YS: janiceys@hku.hken_US
dc.identifier.emailChiu, K: datwai@hkucc.hku.hken_US
dc.identifier.emailSo, KF: hrmaskf@hku.hken_US
dc.identifier.emailChang, RCC: rccchang@hku.hken_US
dc.identifier.authoritySo, KF=rp00329en_US
dc.identifier.authorityChang, RCC=rp00470en_US
dc.identifier.scopuseid_2-s2.0-84892111388-
dc.identifier.hkuros199659en_US
dc.identifier.spage157en_US
dc.identifier.epage186en_US
dc.publisher.placeNew York, NYen_US
dc.customcontrol.immutableyiu 130826-

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