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Article: Low dose of corticosterone treatment with exercise increases hippocampal cell proliferation, and improves cognition

TitleLow dose of corticosterone treatment with exercise increases hippocampal cell proliferation, and improves cognition
Authors
KeywordsHippocampal cell proliferation
Neural plasticity
Physical exercise
Spatial learning
Stress
Structural plasticity
Issue Date2011
PublisherNeural Regeneration Research. The Journal's web site is located at http://www.nrronline.org/nrren/ch/index.aspx
Citation
Neural Regeneration Research, 2011, v. 6 n. 34, p. 2645-2655 How to Cite?
AbstractIntermediate level of stress is beneficial for brain functions, whereas extreme low level or high level of stress is deleterious. We have previously shown that chronic exposure to high doses of corticosterone (CORT) suppressed hippocampal plasticity and physical exercise in terms of running counteracted the detrimental effects of CORT treatment. We aimed to study whether a mild stress, that mimicked by a treatment with low CORT dose, improved hippocampal plasticity in terms of hippocampal cell proliferation and dendritic remodeling, and to examine whether running with CORT treatment showed an additive effect on improving hippocampal plasticity. The rats were treated with 20 mg/kg CORT for 14 days with or without running, followed by Morris water maze test or forced swim test. The hippocampal proliferating cells was labeled by intraperitoneal injection of 5-bromo-2'-deoxyuridine. The dendritic morphology was analyzed using Golgi staining method. Treatment with 20 mg/kg CORT alone yielded a higher number of hippocampal cell proliferation and significantly increased dendritic branching compared to vehicle-treated non-runners, but had no behavioral effects. In contrast, CORT treatment with running showed an additive increase in hippocampal cell proliferation and dendritic remodeling that was associated with improved spatial learning and decreased depression-like behavior; however, there was no additive improvement in behavior compared to vehicle-treated runners. These findings suggest that mild stress does not always cause detrimental effect on the brain, and combining mild stress with running could promote hippocampal plasticity via inducing cell proliferation and dendritic remodeling.
Persistent Identifierhttp://hdl.handle.net/10722/147041
ISSN
2015 Impact Factor: 0.968
2015 SCImago Journal Rankings: 0.337
ISI Accession Number ID
Funding AgencyGrant Number
University of Hong Kong Foundation for Educational Development and Research Limited)
National Natural Science Foundation of China
University Grants Committee of the Hong Kong
University of Hong Kong21609101
Fundamental Research Funds for the Central Universities09ykpy25
09ykpy31
Funding Information:

Supported by: Jessie Ho Professorship in Neuroscience (The University of Hong Kong Foundation for Educational Development and Research Limited)*; the National Natural Science Foundation of China*; the Areas of Excellence (AoE) Scheme Established under the University Grants Committee of the Hong Kong and AoE Matching Fund from the University of Hong Kong, No. 21609101*; the Fundamental Research Funds for the Central Universities, No. 09ykpy25*, 09ykpy31*

References

 

DC FieldValueLanguage
dc.contributor.authorYau, SYen_HK
dc.contributor.authorLee, JCDen_HK
dc.contributor.authorLau, BWMen_HK
dc.contributor.authorLee, TMCen_HK
dc.contributor.authorChing, YPen_HK
dc.contributor.authorTang, SWen_HK
dc.contributor.authorSo, KFen_HK
dc.date.accessioned2012-05-23T05:54:27Z-
dc.date.available2012-05-23T05:54:27Z-
dc.date.issued2011en_HK
dc.identifier.citationNeural Regeneration Research, 2011, v. 6 n. 34, p. 2645-2655en_HK
dc.identifier.issn1673-5374en_HK
dc.identifier.urihttp://hdl.handle.net/10722/147041-
dc.description.abstractIntermediate level of stress is beneficial for brain functions, whereas extreme low level or high level of stress is deleterious. We have previously shown that chronic exposure to high doses of corticosterone (CORT) suppressed hippocampal plasticity and physical exercise in terms of running counteracted the detrimental effects of CORT treatment. We aimed to study whether a mild stress, that mimicked by a treatment with low CORT dose, improved hippocampal plasticity in terms of hippocampal cell proliferation and dendritic remodeling, and to examine whether running with CORT treatment showed an additive effect on improving hippocampal plasticity. The rats were treated with 20 mg/kg CORT for 14 days with or without running, followed by Morris water maze test or forced swim test. The hippocampal proliferating cells was labeled by intraperitoneal injection of 5-bromo-2'-deoxyuridine. The dendritic morphology was analyzed using Golgi staining method. Treatment with 20 mg/kg CORT alone yielded a higher number of hippocampal cell proliferation and significantly increased dendritic branching compared to vehicle-treated non-runners, but had no behavioral effects. In contrast, CORT treatment with running showed an additive increase in hippocampal cell proliferation and dendritic remodeling that was associated with improved spatial learning and decreased depression-like behavior; however, there was no additive improvement in behavior compared to vehicle-treated runners. These findings suggest that mild stress does not always cause detrimental effect on the brain, and combining mild stress with running could promote hippocampal plasticity via inducing cell proliferation and dendritic remodeling.en_HK
dc.languageengen_US
dc.publisherNeural Regeneration Research. The Journal's web site is located at http://www.nrronline.org/nrren/ch/index.aspxen_HK
dc.relation.ispartofNeural Regeneration Researchen_HK
dc.subjectHippocampal cell proliferationen_HK
dc.subjectNeural plasticityen_HK
dc.subjectPhysical exerciseen_HK
dc.subjectSpatial learningen_HK
dc.subjectStressen_HK
dc.subjectStructural plasticityen_HK
dc.titleLow dose of corticosterone treatment with exercise increases hippocampal cell proliferation, and improves cognitionen_HK
dc.typeArticleen_HK
dc.identifier.emailLee, TMC:tmclee@hku.hken_HK
dc.identifier.emailChing, YP:ypching@hku.hken_HK
dc.identifier.emailSo, KF:hrmaskf@hkucc.hku.hken_HK
dc.identifier.authorityLee, TMC=rp00564en_HK
dc.identifier.authorityChing, YP=rp00469en_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.3969/j.issn.1673-5374.2011.34.001en_HK
dc.identifier.scopuseid_2-s2.0-84863115628-
dc.identifier.hkuros199444en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84857389742&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume6en_HK
dc.identifier.issue34en_HK
dc.identifier.spage2645en_HK
dc.identifier.epage2655en_HK
dc.identifier.isiWOS:000299040500001-
dc.publisher.placeChinaen_HK
dc.identifier.scopusauthoridYau, SY=24330296200en_HK
dc.identifier.scopusauthoridLee, JCD=55020582400en_HK
dc.identifier.scopusauthoridLau, BWM=21934562200en_HK
dc.identifier.scopusauthoridLee, TMC=7501437381en_HK
dc.identifier.scopusauthoridChing, YP=7005431277en_HK
dc.identifier.scopusauthoridTang, SW=55021650100en_HK
dc.identifier.scopusauthoridSo, KF=34668391300en_HK

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